ID  P06782;
PN  Carbon catabolite-derepressing protein kinase;
GN  SNF1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:25869125}. Nucleus {ECO:0000269|PubMed:25869125}. Nucleus membrane {ECO:0000269|PubMed:17237508}; Peripheral membrane protein {ECO:0000269|PubMed:17237508}. Note=Nuclear translocation occurs under nitrogen and glucose starvation conditions (PubMed:25869125). {ECO:0000269|PubMed:25869125}.
DR  UNIPROT: P06782;
DR  UNIPROT: D6VTA0;
DR  PDB: 2FH9;
DR  PDB: 2QLV;
DR  PDB: 3DAE;
DR  PDB: 3HYH;
DR  PDB: 3MN3;
DR  PDB: 3T4N;
DR  PDB: 3TDH;
DR  PDB: 3TE5;
DR  Pfam: PF16579;
DR  Pfam: PF00069;
DR  Pfam: PF08587;
DR  PROSITE: PS00107;
DR  PROSITE: PS50011;
DR  PROSITE: PS00108;
DE  Function: Serine/threonine protein kinase essential for release from glucose repression (PubMed:3526554, PubMed:6366512, PubMed:3049551, PubMed:1944227, PubMed:8289797, PubMed:8628258, PubMed:25869125). Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes (PubMed:8289797, PubMed:26667037). The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation through TBP recruitment to the promoters (PubMed:15719021). The complex also negatively regulates the HOG1 MAPK pathway in ER stress response including unfolded protein response (UPR) (PubMed:25730376, PubMed:26394309). Under nutrient/energy depletion, the complex phosphorylates and activates PAS kinase PSK1 which in turn activates PBS1, leading to the inhibition of the TORC1 signaling pathway (PubMed:25428989). SNF1 also interacts and phosphorylates adenylate cyclase CYR1 and negatively regulates the protein kinase A signaling pathway (PubMed:26309257). Also phosphorylates and regulates the transcriptional activator CAT8 (PubMed:15121831). {ECO:0000269|PubMed:15121831, ECO:0000269|PubMed:15719021, ECO:0000269|PubMed:1944227, ECO:0000269|PubMed:25428989, ECO:0000269|PubMed:25730376, ECO:0000269|PubMed:25869125, ECO:0000269|PubMed:26309257, ECO:0000269|PubMed:26394309, ECO:0000269|PubMed:26667037, ECO:0000269|PubMed:3049551, ECO:0000269|PubMed:3526554, ECO:0000269|PubMed:6366512, ECO:0000269|PubMed:8289797, ECO:0000269|PubMed:8628258}.
DE  Reference Proteome: Yes;
DE  Interaction: Q04739; IntAct: EBI-391371; Score: 0.86
DE  Interaction: P34164; IntAct: EBI-391374; Score: 0.91
DE  Interaction: P40151; IntAct: EBI-391377; Score: 0.37
DE  Interaction: Q03957; IntAct: EBI-7822865; Score: 0.51
DE  Interaction: P12904; IntAct: EBI-6956627; Score: 0.97
DE  Interaction: P11484; IntAct: EBI-804120; Score: 0.53
DE  Interaction: P32578; IntAct: EBI-804120; Score: 0.67
DE  Interaction: Q00816; IntAct: EBI-804120; Score: 0.72
DE  Interaction: P38990; IntAct: EBI-804120; Score: 0.56
DE  Interaction: P22204; IntAct: EBI-821767; Score: 0.35
DE  Interaction: P32598; IntAct: EBI-821800; Score: 0.35
DE  Interaction: P07270; IntAct: EBI-821981; Score: 0.35
DE  Interaction: P36047; IntAct: EBI-822217; Score: 0.35
DE  Interaction: P14693; IntAct: EBI-855112; Score: 0.00
DE  Interaction: P0CG63; IntAct: EBI-7480635; Score: 0.44
DE  Interaction: Q04049; IntAct: EBI-7569766; Score: 0.40
DE  Interaction: P40433; IntAct: EBI-7452404; Score: 0.35
DE  Interaction: Q84VQ1; IntAct: EBI-2042520; Score: 0.37
DE  Interaction: Q9SCY5; IntAct: EBI-2042539; Score: 0.37
DE  Interaction: Q42384; IntAct: EBI-2107111; Score: 0.37
DE  Interaction: P32562; IntAct: EBI-2112894; Score: 0.35
DE  Interaction: Q08732; IntAct: EBI-2610513; Score: 0.35
DE  Interaction: P22211; IntAct: EBI-2612723; Score: 0.50
DE  Interaction: P47035; IntAct: EBI-2613798; Score: 0.35
DE  Interaction: Q00684; IntAct: EBI-2613798; Score: 0.50
DE  Interaction: P80667; IntAct: EBI-7469935; Score: 0.37
DE  Interaction: P10591; IntAct: EBI-3677386; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3729858; Score: 0.35
DE  Interaction: P25491; IntAct: EBI-3766560; Score: 0.35
DE  Interaction: P09435; IntAct: EBI-3775934; Score: 0.35
DE  Interaction: P39987; IntAct: EBI-3788442; Score: 0.35
DE  Interaction: P02829; IntAct: EBI-3814316; Score: 0.35
DE  Interaction: P31539; IntAct: EBI-3827904; Score: 0.35
DE  Interaction: P11792; IntAct: EBI-4567519; Score: 0.44
DE  Interaction: P50222; IntAct: EBI-11522962; Score: 0.56
DE  Interaction: Q9UKT9; IntAct: EBI-11523031; Score: 0.56
DE  Interaction: Q9BQ66; IntAct: EBI-11523022; Score: 0.56
DE  Interaction: Q99750; IntAct: EBI-11523013; Score: 0.56
DE  Interaction: Q8N5R6; IntAct: EBI-11522974; Score: 0.56
DE  Interaction: P14373; IntAct: EBI-11522995; Score: 0.56
DE  Interaction: O43597; IntAct: EBI-11522986; Score: 0.56
DE  Interaction: P54619; IntAct: EBI-11523004; Score: 0.56
DE  Interaction: P30822; IntAct: EBI-11611503; Score: 0.35
DE  Interaction: P06782; IntAct: EBI-15573379; Score: 0.74
DE  Interaction: Q06213; IntAct: EBI-15978232; Score: 0.37
DE  Interaction: P38782; IntAct: EBI-15978215; Score: 0.37
DE  Interaction: P32570; IntAct: EBI-15978331; Score: 0.37
DE  Interaction: P47821; IntAct: EBI-15978390; Score: 0.37
DE  Interaction: Q00776; IntAct: EBI-16263794; Score: 0.35
DE  Interaction: Q99186; IntAct: EBI-16263964; Score: 0.35
DE  Interaction: P07260; IntAct: EBI-16265957; Score: 0.35
DE  Interaction: P24719; IntAct: EBI-16273423; Score: 0.35
DE  Interaction: P38622; IntAct: EBI-16279033; Score: 0.35
DE  Interaction: Q04279; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P07259; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P04838; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P02557; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P09733; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P02994; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P25567; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P11075; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P10659; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P09232; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P04806; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: Q04233; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P04385; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P07149; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P25694; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P29311; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P11076; IntAct: EBI-16283487; Score: 0.35
DE  Interaction: P38915; IntAct: EBI-16284064; Score: 0.40
DE  Interaction: Q03897; IntAct: EBI-16287729; Score: 0.35
DE  Interaction: P18961; IntAct: EBI-16292335; Score: 0.35
DE  Interaction: P38232; IntAct: EBI-16397973; Score: 0.51
GO  GO:0000144;
GO  GO:0005737;
GO  GO:0005739;
GO  GO:0005641;
GO  GO:0031965;
GO  GO:0031588;
GO  GO:0005634;
GO  GO:0005774;
GO  GO:0004679;
GO  GO:0005524;
GO  GO:0005085;
GO  GO:0042802;
GO  GO:0140677;
GO  GO:0004672;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0005975;
GO  GO:0007155;
GO  GO:0006995;
GO  GO:0000132;
GO  GO:0030447;
GO  GO:0071940;
GO  GO:0035556;
GO  GO:0001403;
GO  GO:0017148;
GO  GO:1900436;
GO  GO:0045722;
GO  GO:0016239;
GO  GO:2000222;
GO  GO:0006468;
GO  GO:1904547;
GO  GO:2000217;
GO  GO:0034976;
GO  GO:0006986;
GO  GO:0090606;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:17237508};
SQ  MSSNNNTNTAPANANSSHHHHHHHHHHHHHGHGGSNSTLNNPKSSLADGAHIGNYQIVKTLGEGSFGKVKLAYHTTTGQK
SQ  VALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQ
SQ  IISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGV
SQ  ILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEYLLPPDLK
SQ  PHPEEENENNDSKKDGSSPDNDEIDDNLVNILSSTMGYEKDEIYESLESSEDTPAFNEIRDAYMLIKENKSLIKDMKANK
SQ  SVSDELDTFLSQSPPTFQQQSKSHQKSQVDHETAKQHARRMASAITQQRTYHQSPFMDQYKEEDSTVSILPTSLPQIHRA
SQ  NMLAQGSPAASKISPLVTKKSKTRWHFGIRSRSYPLDVMGEIYIALKNLGAEWAKPSEEDLWTIKLRWKYDIGNKTNTNE
SQ  KIPDLMKMVIQLFQIETNNYLVDFKFDGWESSYGDDTTVSNISEDEMSTFSAYPFLHLTTKLIMELAVNSQSN
//