ID  P0C6F7;
PN  Non-structural protein 11;
GN  1a;
OS  389230;
SL  Nucleus Position: SL-0382;
SL  Comments: [Non-structural protein 3]: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. [Non-structural protein 4]: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. [Non-structural protein 6]: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. [Non-structural protein 7]: Host cytoplasm, host perinuclear region {ECO:0000250}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). {ECO:0000250}. [Non-structural protein 8]: Host cytoplasm, host perinuclear region {ECO:0000250}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). {ECO:0000250}. [Non-structural protein 9]: Host cytoplasm, host perinuclear region {ECO:0000250}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). {ECO:0000250}. [Non-structural protein 10]: Host cytoplasm, host perinuclear region {ECO:0000250}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). {ECO:0000250}.
DR  UNIPROT: P0C6F7;
DR  UNIPROT: Q0Q4F3;
DR  Pfam: PF16251;
DR  Pfam: PF11501;
DR  Pfam: PF11633;
DR  Pfam: PF09401;
DR  Pfam: PF19212;
DR  Pfam: PF19211;
DR  Pfam: PF19218;
DR  Pfam: PF16348;
DR  Pfam: PF19217;
DR  Pfam: PF19213;
DR  Pfam: PF08716;
DR  Pfam: PF08717;
DR  Pfam: PF08710;
DR  Pfam: PF08715;
DR  Pfam: PF01661;
DR  Pfam: PF05409;
DR  PROSITE: PS51963;
DR  PROSITE: PS51942;
DR  PROSITE: PS51941;
DR  PROSITE: PS51994;
DR  PROSITE: PS51945;
DR  PROSITE: PS51952;
DR  PROSITE: PS51962;
DR  PROSITE: PS51991;
DR  PROSITE: PS51990;
DR  PROSITE: PS51989;
DR  PROSITE: PS51992;
DR  PROSITE: PS51943;
DR  PROSITE: PS51944;
DR  PROSITE: PS51946;
DR  PROSITE: PS51949;
DR  PROSITE: PS51950;
DR  PROSITE: PS51951;
DR  PROSITE: PS51442;
DR  PROSITE: PS51154;
DR  PROSITE: PS51124;
DE  Function: The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3. {ECO:0000269|PubMed:19264783}. [3C-like proteinase]: Responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|- [SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln- CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). {ECO:0000255|PROSITE-ProRule:PRU00772}. Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter. {ECO:0000250}. Nsp9 is a ssRNA-binding protein. {ECO:0000250}. [Non-structural protein 1]: Binds to the 40S ribosomal subunit and inhibits host translation. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response. {ECO:0000269|PubMed:19264783}.
DE  Reference Proteome: Yes;
GO  GO:0033644;
GO  GO:0044220;
GO  GO:0016021;
GO  GO:0004843;
GO  GO:0004197;
GO  GO:0002151;
GO  GO:0042802;
GO  GO:0008242;
GO  GO:0003727;
GO  GO:0016740;
GO  GO:0008270;
GO  GO:0039595;
GO  GO:0039520;
GO  GO:0039648;
GO  GO:0006508;
GO  GO:0039657;
GO  GO:0039579;
GO  GO:0039502;
GO  GO:0039548;
GO  GO:0019079;
GO  GO:0019082;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MLSKAGVTTQGARGKYRAELYNEKRSDHVACTVPLCDTEDMASKLTPWFEDGETAFNQVSSILKEKGKILFVPMHMQRAM
SQ  KFLPGPRVYLVERLTGGMLSKHFLVNQLAYKDHVGAAMMRTTLNVKPLGMFFPYDSSLETGEHTFLLRKNGLGGQLFRER
SQ  PWDRKETPYVEILDDLEADPTGKYSQNLLKKLIGGDCIPVDQYMCGKNGKPIADYAKIVAKEGLTTLADIEVDVKSRMDS
SQ  DRFIVLNKKLYRVVWNVTRRNVPYSKQTAFTVVSVIQCDDKESVPEHTFTIGSQILMVSPLKATNNKNFNLKQRLLHTFY
SQ  GKEAVQQPGYIYHSAYVDCNACGRGTWCTGNAIQGFACDCGANYSANDVDLQSSGLVPKNALFLANCPCANNGACSHNAA
SQ  QVYSILDGKACVEVGGKSFTLTFGGVVYAYMGCCDGTMYFVPRAKSCVSRIGDAIFTGCTGTWDKVVETANLFLEKAQHS
SQ  LNFCQQFALTEVVLAILSGTTSTFEELRDLCHNASYEKVRDHLVNHGFVVTIGDYIRDAINIGANGVCNATINAPFIAFT
SQ  GLGESFKKVAAIPWKICSNLKSALDYYCSNIMFRVFPYDIPCDVNDFVELLLDCGKLTVATSYFVLRYLDEKFDTVLGTV
SQ  SNACQTALSSFLNACVAASRATAGFISDMFKLFKVLMHKLYVYTSCGYVAVAEHSSKIVQQVLDIMSKAMKLLHTNVSWA
SQ  GTKLSAIIYEGREALLFNSGTYFCLSTKAKTLQDQMNLVLPGDYNKKTLGILDPVPNADTIDVTANSTVVDVVHGQLEPT
SQ  NEHGPSMIVGNYVLVSDKLFVRTDDEEFYPLCINGKVVSTLFRLKGGMPSKKVTFGDVNTVEVTAYRSVSITYDIHPVLD
SQ  ALLSSSKLATFTVEKDLLVEDFVDVIKDEVLTLLTPLLRGYDIDGFDVEDFIDVPCYVYNQDGDCAWSSNMTFSINPVED
SQ  VEEVEEFIEDDYLSDELPIADDEEAWTRAVEEVMPLDDILVAEIELEEDLPLETALESVEAEVGESISDELCVVETAKAQ
SQ  EPSVESTDSTPSTSTVVSENDLSVKPMSRVAETGDVLEVETAVVGGPVSDVTASVVTNDIVSVEQAQQCGVSSLPIQDEA
SQ  SENQVHQVPDLQCTSETKVEIVQPRQDLRPRRLRKSKVDLSKYKHTVINNSVTLVLGDAIQIASLLPKCVLVNAANRHLK
SQ  HGGGIAGAINKASGGDVQEESDEYISNSGPLHVGDSVLLKGYGLADAILRVVGPDARNNEDAALLKRCYKTFNKHTIVVT
SQ  PLISSGIFSVDPKVSFEYLLANVTTTTYVVVNNEDIYNTLATPSKPDGLVYSFEGWRGTVRTAKNYGFTCFICTEYSANV
SQ  KFLRTKGVDTTKKIQTVDGVSYYLYSARDALTDVIAAANGCPGICAMPFGYVTHGLDLAQSGNYVRQVKVPYVCLLASKE
SQ  QIPIMNSDVAIQTPETAFINNVTSNGGYHSWHLVSGDLIVKDVCYKKLLHWSGQTICYADNKFYVVKNDVALPFSDLEAC
SQ  RAYLTSRAAQQVNIEVLVTIDGVNFRTVILNDATTFRKQLGATFYKGVDISDALPTVKMGGESLFVADNLSESEEVVLKE
SQ  YYGTSDVTFLQRYYSLQPLVQQWKFVVHDGVKSLKLSNYNCYINATIMMIDMLHDIKFVVPALQNAYLRYKGGDPYDFLA
SQ  LIMAYGDCTFDNPDDEAKLLHTLLAKAELTVSAKMVWREWCTVCGIRDIEYTGMRACVYAGVNSMEELQSVFNETCVCGS
SQ  VKHRQLVEHSTPWLLVSGLNEVKVSTSTDPVYRAFNVFQGVETSVGHYVHVRVKDGLFYKYDSGSLTKTSDMKCKMTSVW
SQ  YPKVRYTADCNVVVYDLDGVTKVEVNPDLSNYYMKDGKYYTSKPTIKYSPATILPGSVYSNSCLVGVDGTPGSDTISKFF
SQ  NDLLGFDETKPISKKLTYSLLPNEDGDVLLSEFNNYNPVYKKGVMLKGKPILWVNNGVCDSALNKPNRASLRQLYDVAPI
SQ  VLDNKYTVLQDNTSQLIEPNVPVVEDVSITTRKLIEVKCKGLNKPFVKGNFSFVNDPNGVTVVDTLGLTELRALYVDINT
SQ  RYIVLRDNNWSSLFKLHTVESGDLQIVANGGSVTRRARVLLGASSLFASFAKITVTATTAACKTAGRSFCKFVVNYGVLQ
SQ  NMFLFLKMLFFLPFNYLWPKKQPTVDVGVSGLRTAGVVTTNIVKQCGTAAYYMLLGKFKRVDWKATLRLFLLLCTTILLL
SQ  SSIYHLVIFNQVLSSDVMLEDATGILAMYKEVRSYLGIRTLCDGLAVEYRNTSFDVVDFCSNRSVLCQWCLIGQDSLTRY
SQ  SALQMLQTHITSYVLNIDWIWFALEFFLAYVLYTSSFNVLLLVVTAQYFFAYTSAFVNWRAYNYIVSGLFFLVTHIPLHG
SQ  LVRVYNFLACLWFLRKFYSHVINGCKDTACLLCYKRNRLTRVEASTIVCGTKRTFYIAANGGTSYCCKHNWNCVECDTAG
SQ  VGNTFICTEVANDLTTTLRRLIKPTDQSHYYVDSVVVKDAVVELHYNRDGSSCYERYPLCYFTNLEKLKFKEVCKTPTGI
SQ  PEHNFLIYDTNDRGQENLARSACVYYSQVLCKPMLLVDVNLVTTVGDSREIAIKMLDSFINSFISLFSVSRDKLEKLINT
SQ  ARDCVRRGDDFQTVLKTFTDAARGHAGVESDVETTMVVDALQYAHKNDIQLTTECYNNYVPGYIKPDSINTLDLGCLIDL
SQ  KAASVNQTSMRNANGACVWNSGDYMKLSDSFKRQIRIACRKCNIPFRLTTSKLRAADNILSVKFSATKIVGGAPSWLLRV
SQ  RDLTVKGYCILTLFVFTVAVLSWFCLPSYSIATVNFNDDRILTYKVIENGIVRDIAPNDACFANKYGHFSKWFNENHGGV
SQ  YRNSVDCPITIAVIAGVAGARVANVPATLAWVGRQIVLFVSRVFANTNVCFTPTNEIPYDTFSDSGCVLSSECTLFRDAE
SQ  GNLNPFCYDPTVLPGASSYADMKPHVRYDMYDSDMYIKFPEVIFESTLRITKTLATQYCRFGSCEESAAGVCISTNGSWA
SQ  LYNQNYSTRPGIYCGDDYFDIVRRLAVSLFQPVTYFQLSTSLAMGLVLCVFLTAAFYYINKVKRALADYTQCAVVAVVAA
SQ  LLNSLCLCFIVANPLLVAPYTAMYYYATFYLTGEPAFIMHISWYVMFGTVVPIWMLASYTVGVMLRHLFWVLAYFSKKHV
SQ  DVFTDGKLNCSFQDAASNIFVIGKDTYVALRNAITQDSFVRYLSLFNKYKYYSGAMDTASYREACAAHLCKALQTYSETG
SQ  SDILYQPPNCSVTSSVLQSGLVKMSAPSGAVENCIVQVTCGSMTLNGLWLDNTVWCPRHIMCPADQLTDPNYDALLISKT
SQ  NHSFIVQKHIGAQANLRVVAHSMVGVLLKLTVDVANPSTPAYTFSTVKPGASFSVLACYNGKPTGVFTVNLRHNSTIKGS
SQ  FLCGSCGSVGYTENGGVLNFVYMHQMELSNGTHTGSSFDGVMYGAFEDKQTHQLQLTDKYCTINVVAWLYAAVLNGCKWF
SQ  VKPTRVGIVTYNEWALSNQFTEFVGTQSIDMLAHRTGVSVEQMLAAIQSLHAGFQGKTILGQSTLEDEFTPDDVNMQVMG
SQ  VVMQSGVKRISYGFMHWLMSTLVLAYVSVMQLTKFTMWTYLFETIPTQMTPLLFGFMACVMFTVKHKHTFLSLFLLPVAL
SQ  CLTYANIVYEPQTLVSSTLIAVANWLTPTSVYMRTTHLDFGLYISLSFVLAIIVRRLYRPSMSNLALALCSGVMWFYTYV
SQ  IGDHSSPITYLMFITTLTSDYTITVFATVNLAKFISGLVFLYAPHLGFILPEVKLVLLIYLCLGYMCTMYFGVFSLLNLK
SQ  LRVPLGVYDYSVSTQEFRFLTGNGLHAPRNSWEALILNFKLLGIGGTPCIKVATVQSKLTDLKCTSVVLLTVLQQLHLES
SQ  NSKAWSYCVKLHNEILAAVDPTEAFERFVCLFATLMSFSANVDLDALANDLFENSSVLQATLTEFSHLATYAELETAQSS
SQ  YQKALNSGDASPQVLKALQKAVNVAKNAYEKDKAVARKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDN
SQ  DVLNGVIANARNGCVPLSIVPLCASNKLRVVIPDISVWNKVVNWPSVSYAGSLWDVTVINNVDNEVVKPTDVVETNESLT
SQ  WPLVIECSRASSSAVKLQNNEIHPKGLKTMVVTAGIDQVNCSSSAVAYYEPVQGHRMVMGLLSENAHLKWAKVEGKDGFI
SQ  NIELQPPCKFLIAGPKGPEIRYLYFVKNLNNLHRGQLLGHIAATVRLQAGANTEFASNSTVLTLVAFAVDPAKAYLDYVG
SQ  SGGTPLSNYVKMLAPKTGTGVAISVKPEATADQETYGGASVCLYCRAHIEHPDVSGVCKYKTRFVQIPAHVRDPVGFLLK
SQ  NVPCNVCQYWVGYGCNCDALRNNTVPQSKDTNFLNESGVLV
//