ID  P0C6F8;
PN  Non-structural protein 11;
GN  1a;
OS  442736;
SL  Nucleus Position: SL-0382;
SL  Comments: [Non-structural protein 3]: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. [Non-structural protein 4]: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. [Non-structural protein 6]: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. [Non-structural protein 7]: Host cytoplasm, host perinuclear region {ECO:0000250}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). {ECO:0000250}. [Non-structural protein 8]: Host cytoplasm, host perinuclear region {ECO:0000250}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). {ECO:0000250}. [Non-structural protein 9]: Host cytoplasm, host perinuclear region {ECO:0000250}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). {ECO:0000250}. [Non-structural protein 10]: Host cytoplasm, host perinuclear region {ECO:0000250}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). {ECO:0000250}.
DR  UNIPROT: P0C6F8;
DR  UNIPROT: Q3LZX2;
DR  Pfam: PF16251;
DR  Pfam: PF11501;
DR  Pfam: PF12379;
DR  Pfam: PF12124;
DR  Pfam: PF11633;
DR  Pfam: PF09401;
DR  Pfam: PF19212;
DR  Pfam: PF19211;
DR  Pfam: PF19218;
DR  Pfam: PF16348;
DR  Pfam: PF19217;
DR  Pfam: PF19213;
DR  Pfam: PF08716;
DR  Pfam: PF08717;
DR  Pfam: PF08710;
DR  Pfam: PF08715;
DR  Pfam: PF01661;
DR  Pfam: PF05409;
DR  PROSITE: PS51963;
DR  PROSITE: PS51942;
DR  PROSITE: PS51941;
DR  PROSITE: PS51994;
DR  PROSITE: PS51945;
DR  PROSITE: PS51952;
DR  PROSITE: PS51962;
DR  PROSITE: PS51991;
DR  PROSITE: PS51990;
DR  PROSITE: PS51989;
DR  PROSITE: PS51992;
DR  PROSITE: PS51943;
DR  PROSITE: PS51944;
DR  PROSITE: PS51946;
DR  PROSITE: PS51949;
DR  PROSITE: PS51950;
DR  PROSITE: PS51951;
DR  PROSITE: PS51442;
DR  PROSITE: PS51154;
DR  PROSITE: PS51124;
DR  PROSITE: PS51940;
DE  Function: The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3 (By similarity). {ECO:0000250}. [3C-like proteinase]: Responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|- [SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln- CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). {ECO:0000255|PROSITE-ProRule:PRU00772}. Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter. {ECO:0000250}. Nsp9 is a ssRNA-binding protein. {ECO:0000250}. [Non-structural protein 1]: Binds to the 40S ribosomal subunit and inhibits host translation. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (By similarity). {ECO:0000250}.
DE  Reference Proteome: No;
GO  GO:0033644;
GO  GO:0044220;
GO  GO:0016021;
GO  GO:0004843;
GO  GO:0004197;
GO  GO:0002151;
GO  GO:0042802;
GO  GO:0008242;
GO  GO:0003727;
GO  GO:0016740;
GO  GO:0008270;
GO  GO:0039595;
GO  GO:0039520;
GO  GO:0039648;
GO  GO:0006508;
GO  GO:0039657;
GO  GO:0039579;
GO  GO:0039502;
GO  GO:0039548;
GO  GO:0019079;
GO  GO:0019082;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGVLPQLEQPYVFIKRSDALSTN
SQ  HGHKVVELVAELDGIQFGRSGITLGVLVPHVGETPIAYRNVLLRKNGNKGAGGHSFGIDLKSYDLGDELGTDPIEDYEQN
SQ  WNTKHGSGALRELTRELNGGVVTRYVDNNFCGPDGYPLECIKDFLARAGKSMCTLSEQLDYIESKRGVYCCREHEHEIVW
SQ  FTERSEKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVATPQECNDMHLSTL
SQ  MKCNHCDEVSWQTCDFLKATCEQCGTENLVCEGPTTCGYLPTNAVVKMPCPACQDPEVGPEHSVADYHNHSNIETRLRKG
SQ  GRTKCFGGCVFSYVGCYNKRAYWVPRASANIGANHTGITGENVETLNEDLLEILNRERVNINIVGDFRFNEEVAIILASF
SQ  SASPSAFIETVKGLDYKSFKVIVESCGNYKVTNGKPVTGAWNIGQQRSILTPLCGFPSQAAGVIRSIFSRTLDAANHSIL
SQ  DLQRAAVTTLDGISEQSLRLVDAMVYTSDLLTNSVVVMAYVTGGLVQQTMQWLSNMLGTAVDKLKPVFTWVEAKLSAGVE
SQ  FLRDAWEILKFLITGVFDVIKGQIQVATDNIKECVKIFLGVVNKALEMCLDQVTIAGTKLRALNLGEVFIAQSRGLYRQC
SQ  IRGKEQLQLLMPLKAPKEVTFLEGDAHDTVLTSEEVVLKSGELEALETPIDSFTSGAVVGTPVCINGLMLLELENKEQYC
SQ  ALSPGLLATNNVFRLKGGAPVKGVTFGEDTVLEVQGYKNVKITFELDVRVDKVLNEKCSVYTVESGTEVTEFACVVAEAV
SQ  VKTLQPVSDLLTPMGIDLDEWSVATFYLFDDAGEEKLSSRMYCSFYPPDEEEDCEECEDEEETCEHEYGTEDDYKGLPLE
SQ  FGASTETPHVEEEEEEEDWLDDAIEAEPEPEPLPEEPVNQFVGYLKLTDNVAIKCIDIVKEAQSAKPTVIVNAANTHLKH
SQ  GGGVAGALNKATNGAMQNESDEYIRQNGPLTVGGSCLLSGHNLAEKCLHVVGPNLNAGEDVQLLKRAYENFNSQDVLLAP
SQ  LLSAGIFGAKPLQSLKMCVEIVRTQVYLAVNDKSLYDQIVLDYLDSLKPKVESPNKEEEPKLEEPKAVQPVAEKPVDVKP
SQ  KIKACIDEVTTTLEETKFLTNKLLLFADINGKLYQDSQNMLRGEDMSFLEKDAPYIVGDVITSGDITCVIIPAKKSGGTT
SQ  EMLARALKEVPVAEYITTYPGQGCAGYTLEEAKTALKKCKSAFYVLPSETPNEKEEVLGTVSWNLREMLAHAEETRKLMP
SQ  ICLDVRAIMATIQRKYKGIKVQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGLNLEEAARCMRSLK
SQ  APAVVSVSSPDAVTAYNGYLTSSSKTPEEYFVETTSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTTGSPIEFHLDGE
SQ  VLPLDKLKSLLSLREVKTIKVFTTVDNTNLHTHIVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRS
SQ  EAFEYYHTIDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQVEVKFNAPALQEAYYRARAGDAAN
SQ  FCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLKGVEAVMYMGTLSYDELKTGVSIPCVC
SQ  GRNATQYLVQQESSFVMMSAPPAEYKLQQGAFLCANEYTGNYQCGHYTHITAKETLYRVDGAHLTKMSEYKGPVTDVFYK
SQ  ETSYTTAIKPVSYKLDGVTYTEIEPKLDGYYKKGNAYYTEQPIDLVPTQPMPNASFDNFKLTCSNTKFADDLNQMTGFKK
SQ  PASRELTVTFFPDLNGDVVAIDYRHYSTSFKKGAKLVHKPILWHINQTTNKTTYKPNIWCLRCLWSTKPVDTSNSFEVLV
SQ  VEDTQGMDNLACESQTTTSEEVVENPTVQKEIIECDVKTTEVVGNVILKPSEEGVKVTQELGHEDLMAAYVEETSITIKK
SQ  PNELSLALGLKTLATHGAAAINSVPWSKILAYVKPFLGQTAVITSNCIKKCVQRVFSNYMPYVITLLFQLCTFTKSTNSR
SQ  IKASLPTTIAKNSVKSVAKLCLDVCINYVKSPKFSKLFTIVMWLLLLSICLGSLTYVTAVLGVCLSSLGVPSYCDGVREL
SQ  YINSSNVTTMDFCQGYFPCSVCLSGLDSLDSYPALETIQVTISSYKLDLTFLGLAAEWLLAYMLFTKFFYLLGLSAIMQA
SQ  FFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYVWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNG
SQ  VKRSFYVYANGGRGFCKAHNWNCLNCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSAYVVDSVTVKNGALHLYFDKAG
SQ  QKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVK
SQ  MFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDIEVTGDS
SQ  CNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLVWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQ
SQ  VVNVITTKISLKGGKVVSTWFKLLLKVTLLCVLAALFCYVIMPVHSLSVHDGYTNEIIGYKAIQDGVTRDIVSTDDCFAN
SQ  KHAGFDSWFSQRGGSYRNDKNCPVVAAIITREIGFIVPGLPGTVLRALNGDFLHFLPRVFSAVGNICYTPSKLIEYSDFA
SQ  TSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTC
SQ  ERSEVGVCLSTSGRWVLNNEHYRALPGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR
SQ  AFGEYNHVVAANALLFLMSFTILCLAPAYSFLPGVYSIFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCIS
SQ  LKHFHWFFSNYLKKRVMFNGVTFSTFEEAALCTFLLNKEMYLRLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREA
SQ  ACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVVCTA
SQ  EDMLNPNYDDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVY
SQ  QCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLA
SQ  WLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTI
SQ  LEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFALGIMAVAACAMLLV
SQ  KHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVW
SQ  TLMNVITLVYKVYYGNSLDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYC
SQ  CCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTS
SQ  VVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFS
SQ  SLPSYAAYATAQEAYEQAVSNGDSEVVLKKLKKSLNVAKSEFDHDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAM
SQ  QTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIV
SQ  QLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNAKGGRFVLALLSDHQ
SQ  DLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSF
SQ  CAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKY
SQ  VQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPMMQSADASTFLNGFAV
//