ID  P0C6T3;
PN  Proline-rich protein 7;
GN  Prr7;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000250|UniProtKB:Q8TB68}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000269|PubMed:15629447}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000269|PubMed:15629447, ECO:0000269|PubMed:27458189}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8TB68}. Synapse {ECO:0000269|PubMed:27458189}. Cell projection, dendrite {ECO:0000269|PubMed:27458189}. Nucleus {ECO:0000269|PubMed:27458189}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD) (PubMed:15629447, PubMed:27458189). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern (PubMed:15629447). Translocates from synapses to nuclei following NMDA receptor activity (PubMed:27458189). {ECO:0000269|PubMed:15629447, ECO:0000269|PubMed:27458189}.
DR  UNIPROT: P0C6T3;
DE  Function: Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (PubMed:27458189). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (By similarity). Might promote apoptosis in T cells (By similarity). {ECO:0000250|UniProtKB:Q8TB68, ECO:0000269|PubMed:27458189}.
DE  Reference Proteome: Yes;
GO  GO:0070161;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0098978;
GO  GO:0016021;
GO  GO:0043005;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0014069;
GO  GO:0098839;
GO  GO:0099092;
GO  GO:0045202;
GO  GO:0036041;
GO  GO:1990782;
GO  GO:0044877;
GO  GO:0044389;
GO  GO:0002250;
GO  GO:0046632;
GO  GO:0031397;
GO  GO:0043065;
GO  GO:0010942;
GO  GO:2001269;
GO  GO:0099527;
GO  GO:0033077;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPPPPHR
SQ  SRLEAPVHAHSHVHVHPLLHHGPAQPHAHPHPHHHALPHPPPSHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPP
SQ  YSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAAPCPALCLQADRSRRVFPSWTD
SQ  SELSSREPLEHGAWRLPVSIPLFGRTTAV
//