ID  P0C6X7;
PN  2'-O-methyltransferase nsp16;
GN  rep;
OS  694009;
SL  Nucleus Position: SL-0382;
SL  Comments: [Non-structural protein 2]: Host cytoplasm {ECO:0000250|UniProtKB:P0DTD1}. Host endosome {ECO:0000250|UniProtKB:P0DTD1}. [Papain-like protease nsp3]: Host membrane {ECO:0000305}; Multi-pass membrane protein. Host cytoplasm {ECO:0000269|PubMed:23943763}. [Non-structural protein 4]: Host membrane; Multi- pass membrane protein. Host cytoplasm {ECO:0000269|PubMed:23943763}. Note=Localizes in virally-induced cytoplasmic double-membrane vesicles. {ECO:0000269|PubMed:17855519, ECO:0000269|PubMed:21345958, ECO:0000269|PubMed:23943763}. [3C-like proteinase nsp5]: Host cytoplasm {ECO:0000250|UniProtKB:P0DTD1}. Host Golgi apparatus {ECO:0000250|UniProtKB:P0DTD1}. [Non-structural protein 6]: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. [Non-structural protein 7]: Host cytoplasm, host perinuclear region {ECO:0000250}. Host cytoplasm {ECO:0000250|UniProtKB:P0DTD1}. Host endoplasmic reticulum {ECO:0000250|UniProtKB:P0DTD1}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes. [Non-structural protein 8]: Host cytoplasm, host perinuclear region {ECO:0000269|PubMed:17532020}. Host cytoplasm {ECO:0000250|UniProtKB:P0DTD1}. Host endoplasmic reticulum {ECO:0000250|UniProtKB:P0DTD1}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes. [Non-structural protein 9]: Host cytoplasm, host perinuclear region {ECO:0000250}. Host cytoplasm {ECO:0000250|UniProtKB:P0DTD1}. Host endoplasmic reticulum {ECO:0000250|UniProtKB:P0DTD1}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes. [Non-structural protein 10]: Host cytoplasm, host perinuclear region {ECO:0000250}. Host cytoplasm {ECO:0000250|UniProtKB:P0DTD1}. Host endoplasmic reticulum {ECO:0000250|UniProtKB:P0DTD1}. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes. [Helicase nsp13]: Host endoplasmic reticulum- Golgi intermediate compartment {ECO:0000305}. Note=The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA. [Proofreading exoribonuclease nsp14]: Host cytoplasm {ECO:0000250|UniProtKB:P0DTD1}. Host endoplasmic reticulum {ECO:0000250|UniProtKB:P0DTD1}. [Uridylate-specific endoribonuclease nsp15]: Host cytoplasm, host perinuclear region {ECO:0000250}.
DR  UNIPROT: P0C6X7;
DR  UNIPROT: P59641;
DR  UNIPROT: Q6WGN0;
DR  UNIPROT: Q7T697;
DR  UNIPROT: Q808C0;
DR  UNIPROT: Q80BV7;
DR  UNIPROT: Q80BV8;
DR  UNIPROT: Q80E51;
DR  PDB: 1Q2W;
DR  PDB: 1QZ8;
DR  PDB: 1UJ1;
DR  PDB: 1UK2;
DR  PDB: 1UK3;
DR  PDB: 1UK4;
DR  PDB: 1UW7;
DR  PDB: 1WOF;
DR  PDB: 1YSY;
DR  PDB: 1Z1I;
DR  PDB: 1Z1J;
DR  PDB: 2A5A;
DR  PDB: 2A5I;
DR  PDB: 2A5K;
DR  PDB: 2ACF;
DR  PDB: 2AHM;
DR  PDB: 2ALV;
DR  PDB: 2AMD;
DR  PDB: 2AMQ;
DR  PDB: 2BX3;
DR  PDB: 2BX4;
DR  PDB: 2C3S;
DR  PDB: 2D2D;
DR  PDB: 2DUC;
DR  PDB: 2FAV;
DR  PDB: 2FE8;
DR  PDB: 2FYG;
DR  PDB: 2G9T;
DR  PDB: 2GA6;
DR  PDB: 2GDT;
DR  PDB: 2GRI;
DR  PDB: 2GT7;
DR  PDB: 2GT8;
DR  PDB: 2GTB;
DR  PDB: 2GX4;
DR  PDB: 2GZ7;
DR  PDB: 2GZ8;
DR  PDB: 2GZ9;
DR  PDB: 2H2Z;
DR  PDB: 2H85;
DR  PDB: 2HOB;
DR  PDB: 2HSX;
DR  PDB: 2IDY;
DR  PDB: 2JZD;
DR  PDB: 2JZE;
DR  PDB: 2JZF;
DR  PDB: 2K7X;
DR  PDB: 2K87;
DR  PDB: 2OP9;
DR  PDB: 2OZK;
DR  PDB: 2PWX;
DR  PDB: 2Q6G;
DR  PDB: 2QC2;
DR  PDB: 2QCY;
DR  PDB: 2QIQ;
DR  PDB: 2RHB;
DR  PDB: 2RNK;
DR  PDB: 2V6N;
DR  PDB: 2VJ1;
DR  PDB: 2XYQ;
DR  PDB: 2XYR;
DR  PDB: 2XYV;
DR  PDB: 2Z3C;
DR  PDB: 2Z3D;
DR  PDB: 2Z3E;
DR  PDB: 2Z94;
DR  PDB: 2Z9G;
DR  PDB: 2Z9J;
DR  PDB: 2Z9K;
DR  PDB: 2Z9L;
DR  PDB: 3D62;
DR  PDB: 3E9S;
DR  PDB: 3EBN;
DR  PDB: 3R24;
DR  PDB: 4TWW;
DR  PDB: 4TWY;
DR  PDB: 4WY3;
DR  PDB: 4ZUH;
DR  PDB: 5B6O;
DR  PDB: 5C5N;
DR  PDB: 5C5O;
DR  PDB: 5C8S;
DR  PDB: 5C8T;
DR  PDB: 5C8U;
DR  PDB: 5E6J;
DR  PDB: 5F22;
DR  PDB: 5N19;
DR  PDB: 5N5O;
DR  PDB: 5NFY;
DR  PDB: 6JYT;
DR  PDB: 6LNQ;
DR  PDB: 6NUR;
DR  PDB: 6NUS;
DR  PDB: 6W79;
DR  PDB: 6WCO;
DR  PDB: 7LCP;
DR  PDB: 7LCQ;
DR  Pfam: PF16251;
DR  Pfam: PF11501;
DR  Pfam: PF12379;
DR  Pfam: PF12124;
DR  Pfam: PF11633;
DR  Pfam: PF06471;
DR  Pfam: PF06460;
DR  Pfam: PF09401;
DR  Pfam: PF19215;
DR  Pfam: PF19216;
DR  Pfam: PF19219;
DR  Pfam: PF19212;
DR  Pfam: PF19211;
DR  Pfam: PF19218;
DR  Pfam: PF16348;
DR  Pfam: PF19217;
DR  Pfam: PF19213;
DR  Pfam: PF08716;
DR  Pfam: PF08717;
DR  Pfam: PF08710;
DR  Pfam: PF08715;
DR  Pfam: PF06478;
DR  Pfam: PF01661;
DR  Pfam: PF05409;
DR  Pfam: PF00680;
DR  Pfam: PF01443;
DR  PROSITE: PS51961;
DR  PROSITE: PS51963;
DR  PROSITE: PS51942;
DR  PROSITE: PS51941;
DR  PROSITE: PS51994;
DR  PROSITE: PS51945;
DR  PROSITE: PS51952;
DR  PROSITE: PS51954;
DR  PROSITE: PS51962;
DR  PROSITE: PS52000;
DR  PROSITE: PS51948;
DR  PROSITE: PS51960;
DR  PROSITE: PS51991;
DR  PROSITE: PS51990;
DR  PROSITE: PS51989;
DR  PROSITE: PS51992;
DR  PROSITE: PS51943;
DR  PROSITE: PS51944;
DR  PROSITE: PS51946;
DR  PROSITE: PS51949;
DR  PROSITE: PS51950;
DR  PROSITE: PS51951;
DR  PROSITE: PS51653;
DR  PROSITE: PS51442;
DR  PROSITE: PS51154;
DR  PROSITE: PS51958;
DR  PROSITE: PS51947;
DR  PROSITE: PS51955;
DR  PROSITE: PS51953;
DR  PROSITE: PS51124;
DR  PROSITE: PS51657;
DR  PROSITE: PS50507;
DR  PROSITE: PS51940;
DE  Function: [Isoform Replicase polyprotein 1ab]: Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein. {ECO:0000305}. [Host translation inhibitor nsp1]: Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (PubMed:23035226). May disrupt nuclear pore function by binding and displacing host NUP93 (PubMed:30943371). {ECO:0000269|PubMed:23035226, ECO:0000269|PubMed:30943371}. [Non-structural protein 2]: May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2 (PubMed:19640993). Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses (PubMed:19640993). {ECO:0000269|PubMed:19640993}. [Papain-like protease nsp3]: Responsible for the cleavages located at the N-terminus of the replicase polyprotein (PubMed:16306590). In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:16306590, PubMed:17692280). Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication (PubMed:23943763). Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:19369340, PubMed:24622840). Prevents also host NF- kappa-B signaling (PubMed:19369340, PubMed:24622840). {ECO:0000269|PubMed:16306590, ECO:0000269|PubMed:17692280, ECO:0000269|PubMed:19369340, ECO:0000269|PubMed:23943763, ECO:0000269|PubMed:24622840, ECO:0000303|PubMed:24410069}. [Non-structural protein 4]: Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication (PubMed:23943763). Alone appears incapable to induce membrane curvature, but together with nsp3 is able to induce paired membranes. Nsp3, nsp4 and nsp6 together are sufficient to form DMV. {ECO:0000269|PubMed:23943763, ECO:0000303|PubMed:24410069}. [3C-like proteinase nsp5]: Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''- phosphate (ADRP). May cleave host ATP6V1G1 thereby modifying host vacuoles intracellular pH. {ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:16226257}. [Non-structural protein 6]: Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication (PubMed:24991833, PubMed:24410069). Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24991833, PubMed:24410069). Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes (PubMed:24991833). {ECO:0000269|PubMed:24991833, ECO:0000303|PubMed:24410069}. [Non-structural protein 7]: Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers. {ECO:0000269|PubMed:22039154}. [Non-structural protein 8]: Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers. {ECO:0000269|PubMed:22039154}. [Non-structural protein 9]: Plays an essential role in viral replication by forming a homodimer that binds single-stranded RNA. {ECO:0000269|PubMed:19153232}. [Non-structural protein 10]: Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation. {ECO:0000269|PubMed:22022266, ECO:0000269|PubMed:22635272}. [RNA-directed RNA polymerase nsp12]: Responsible for replication and transcription of the viral RNA genome. {ECO:0000269|PubMed:22791111}. [Helicase nsp13]: Multi-functional protein with a zinc- binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium. {ECO:0000269|PubMed:12917423, ECO:0000269|PubMed:22615777}. [Proofreading exoribonuclease nsp14]: Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity (PubMed:16549795, PubMed:20421945, PubMed:22635272). Acts as a proofreading exoribonuclease for RNA replication, thereby lowering The sensitivity of the virus to RNA mutagens (PubMed:23966862, PubMed:29511076, PubMed:21593585). {ECO:0000269|PubMed:16549795, ECO:0000269|PubMed:20421945, ECO:0000269|PubMed:21593585, ECO:0000269|PubMed:22635272, ECO:0000269|PubMed:23966862, ECO:0000269|PubMed:29511076}. [Uridylate-specific endoribonuclease nsp15]: Plays a role in viral transcription/replication and prevents the simultaneous activation of host cell dsRNA sensors, such as MDA5/IFIH1, OAS, and PKR (PubMed:28158275, PubMed:18045871). Acts by degrading the 5'- polyuridines generated during replication of the poly(A) region of viral genomic and subgenomic RNAs. Catalyzes a two-step reaction in which a 2'3'-cyclic phosphate (2'3'-cP) is first generated by 2'-O transesterification, which is then hydrolyzed to a 3'-phosphate (3'-P) (PubMed:16828802). If not degraded, poly(U) RNA would hybridize with poly(A) RNA tails and activate host dsRNA sensors (PubMed:28158275, PubMed:18045871). {ECO:0000269|PubMed:16828802, ECO:0000269|PubMed:18045871, ECO:0000269|PubMed:28158275}. [2'-O-methyltransferase nsp16]: Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs (PubMed:18417574, PubMed:22022266, PubMed:20421945). N7- methyl guanosine cap is a prerequisite for binding of nsp16 (PubMed:18417574). Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system (PubMed:18417574, PubMed:22022266, PubMed:20421945). {ECO:0000269|PubMed:18417574, ECO:0000269|PubMed:20421945, ECO:0000269|PubMed:22022266, ECO:0000305}.
DE  Reference Proteome: Yes;
DE  Interaction: K9N638; IntAct: EBI-26366798; Score: 0.44
DE  Interaction: K9N7C7; IntAct: EBI-25758227; Score: 0.44
DE  Interaction: O15182; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: O75821; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: P0C6U8; IntAct: EBI-25492630; Score: 0.51
DE  Interaction: O75348; IntAct: EBI-7843859; Score: 0.66
DE  Interaction: P0C6X7; IntAct: EBI-25490398; Score: 0.89
DE  Interaction: P62937; IntAct: EBI-25488476; Score: 0.51
DE  Interaction: Q9UQN3; IntAct: EBI-25488518; Score: 0.51
DE  Interaction: Q5SQN1; IntAct: EBI-25488935; Score: 0.51
DE  Interaction: Q9Y4W2; IntAct: EBI-25488511; Score: 0.51
DE  Interaction: Q9UKA8; IntAct: EBI-25488504; Score: 0.51
DE  Interaction: O43447; IntAct: EBI-25488497; Score: 0.51
DE  Interaction: Q13427; IntAct: EBI-25488490; Score: 0.51
DE  Interaction: P62942; IntAct: EBI-25488483; Score: 0.51
DE  Interaction: O95299; IntAct: EBI-25489287; Score: 0.40
DE  Interaction: Q8TD31; IntAct: EBI-25488553; Score: 0.55
DE  Interaction: P20231; IntAct: EBI-25488546; Score: 0.37
DE  Interaction: P30876; IntAct: EBI-25488539; Score: 0.37
DE  Interaction: Q15661; IntAct: EBI-25489276; Score: 0.40
DE  Interaction: Q99471; IntAct: EBI-25489298; Score: 0.40
DE  Interaction: Q99426; IntAct: EBI-25488574; Score: 0.37
DE  Interaction: P51948; IntAct: EBI-25488581; Score: 0.37
DE  Interaction: Q13064; IntAct: EBI-25488700; Score: 0.51
DE  Interaction: P09630; IntAct: EBI-25488588; Score: 0.37
DE  Interaction: Q8N488; IntAct: EBI-25488595; Score: 0.51
DE  Interaction: P27448; IntAct: EBI-25488602; Score: 0.37
DE  Interaction: Q7KZI7; IntAct: EBI-25488609; Score: 0.37
DE  Interaction: O96017; IntAct: EBI-25488616; Score: 0.51
DE  Interaction: P05155; IntAct: EBI-25488644; Score: 0.51
DE  Interaction: Q56VL3; IntAct: EBI-25488630; Score: 0.37
DE  Interaction: Q92802; IntAct: EBI-25488637; Score: 0.37
DE  Interaction: Q13561; IntAct: EBI-25488651; Score: 0.37
DE  Interaction: Q8WXF8; IntAct: EBI-25488665; Score: 0.37
DE  Interaction: Q9H000; IntAct: EBI-25488693; Score: 0.51
DE  Interaction: Q7Z3Q1; IntAct: EBI-25488686; Score: 0.37
DE  Interaction: Q7Z494; IntAct: EBI-25488679; Score: 0.37
DE  Interaction: Q13564; IntAct: EBI-25488825; Score: 0.37
DE  Interaction: A9UHW6; IntAct: EBI-25488818; Score: 0.51
DE  Interaction: P62258; IntAct: EBI-25488811; Score: 0.37
DE  Interaction: Q9HCD5; IntAct: EBI-25488804; Score: 0.37
DE  Interaction: P49703; IntAct: EBI-25488797; Score: 0.37
DE  Interaction: Q92560; IntAct: EBI-25488790; Score: 0.37
DE  Interaction: Q8TEB7; IntAct: EBI-25488783; Score: 0.37
DE  Interaction: O95865; IntAct: EBI-25488776; Score: 0.51
DE  Interaction: O14498; IntAct: EBI-25488769; Score: 0.37
DE  Interaction: Q9GZN8; IntAct: EBI-25488762; Score: 0.37
DE  Interaction: P23025; IntAct: EBI-25488755; Score: 0.37
DE  Interaction: P08949; IntAct: EBI-25488727; Score: 0.37
DE  Interaction: Q96GS6; IntAct: EBI-25489377; Score: 0.40
DE  Interaction: Q86VK4; IntAct: EBI-25488707; Score: 0.37
DE  Interaction: Q53GL0; IntAct: EBI-25488844; Score: 0.37
DE  Interaction: P13796; IntAct: EBI-25488851; Score: 0.37
DE  Interaction: Q6P587; IntAct: EBI-25488921; Score: 0.37
DE  Interaction: P23588; IntAct: EBI-25488893; Score: 0.37
DE  Interaction: P54274; IntAct: EBI-25488879; Score: 0.51
DE  Interaction: Q9P0M6; IntAct: EBI-25488872; Score: 0.51
DE  Interaction: Q9Y6E2; IntAct: EBI-25488865; Score: 0.37
DE  Interaction: P69849; IntAct: EBI-25488858; Score: 0.51
DE  Interaction: Q9BUV0; IntAct: EBI-25488907; Score: 0.37
DE  Interaction: P06733; IntAct: EBI-25488928; Score: 0.37
DE  Interaction: P23284; IntAct: EBI-25475813; Score: 0.40
DE  Interaction: P20290; IntAct: EBI-25487623; Score: 0.37
DE  Interaction: P03901; IntAct: EBI-25487628; Score: 0.37
DE  Interaction: P00403; IntAct: EBI-25487633; Score: 0.37
DE  Interaction: Q9Y2D1; IntAct: EBI-25487647; Score: 0.37
DE  Interaction: P59632; IntAct: EBI-25492642; Score: 0.51
DE  Interaction: P59636; IntAct: EBI-25492804; Score: 0.51
DE  Interaction: Q7TFA0; IntAct: EBI-25492912; Score: 0.37
DE  Interaction: P59637; IntAct: EBI-25635717; Score: 0.54
DE  Interaction: Q80H93; IntAct: EBI-25492945; Score: 0.37
DE  Interaction: Q7TLC7; IntAct: EBI-25493011; Score: 0.37
DE  Interaction: P59635; IntAct: EBI-25493519; Score: 0.37
DE  Interaction: Q19QW5; IntAct: EBI-25635410; Score: 0.61
DE  Interaction: P08865; IntAct: EBI-25507413; Score: 0.37
DE  Interaction: P62879; IntAct: EBI-25507431; Score: 0.37
DE  Interaction: Q15047; IntAct: EBI-25507450; Score: 0.37
DE  Interaction: Q9NY15; IntAct: EBI-25507454; Score: 0.37
DE  Interaction: Q9BW92; IntAct: EBI-25507458; Score: 0.37
DE  Interaction: P40337; IntAct: EBI-25507462; Score: 0.60
DE  Interaction: O95433; IntAct: EBI-25507466; Score: 0.37
DE  Interaction: Q8TF42; IntAct: EBI-25507481; Score: 0.37
DE  Interaction: Q0VD86; IntAct: EBI-25507485; Score: 0.37
DE  Interaction: Q14653; IntAct: EBI-25498708; Score: 0.66
DE  Interaction: Q5JRX3; IntAct: EBI-25507493; Score: 0.37
DE  Interaction: Q99873; IntAct: EBI-25507497; Score: 0.37
DE  Interaction: P62487; IntAct: EBI-25507501; Score: 0.37
DE  Interaction: Q9BTC0; IntAct: EBI-25507472; Score: 0.35
DE  Interaction: Q93009; IntAct: EBI-25507472; Score: 0.35
DE  Interaction: Q6IEG0; IntAct: EBI-25507472; Score: 0.35
DE  Interaction: P78345; IntAct: EBI-25507472; Score: 0.35
DE  Interaction: P35250; IntAct: EBI-25507472; Score: 0.35
DE  Interaction: O75131; IntAct: EBI-25507472; Score: 0.35
DE  Interaction: Q14008; IntAct: EBI-25507472; Score: 0.53
DE  Interaction: Q6Y7W6; IntAct: EBI-25507801; Score: 0.53
DE  Interaction: P21796; IntAct: EBI-25507801; Score: 0.35
DE  Interaction: Q9UJZ1; IntAct: EBI-25507801; Score: 0.64
DE  Interaction: Q96T58; IntAct: EBI-25507801; Score: 0.35
DE  Interaction: Q15758; IntAct: EBI-25507801; Score: 0.35
DE  Interaction: Q99623; IntAct: EBI-25507801; Score: 0.64
DE  Interaction: P35232; IntAct: EBI-25507801; Score: 0.64
DE  Interaction: Q15154; IntAct: EBI-25507801; Score: 0.35
DE  Interaction: O14686; IntAct: EBI-25507801; Score: 0.35
DE  Interaction: O60573; IntAct: EBI-25507801; Score: 0.64
DE  Interaction: Q7L2H7; IntAct: EBI-25507801; Score: 0.53
DE  Interaction: Q15751; IntAct: EBI-25688256; Score: 0.40
DE  Interaction: Q9BRX9; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: Q9NZM4; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: Q9H9G7; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: Q9BT78; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: Q99798; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: Q8TDY2; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: Q6NWY9; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: Q15631; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: Q15532; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: Q13228; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: P55786; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: P52756; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: P49903; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: P40925; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: P28066; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: P25789; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: P07954; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: O76064; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: O15498; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: O14979; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: O14732; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: O00268; IntAct: EBI-25688150; Score: 0.35
DE  Interaction: P09525; IntAct: EBI-25688210; Score: 0.35
DE  Interaction: A6NHR9; IntAct: EBI-25688210; Score: 0.35
DE  Interaction: O75781; IntAct: EBI-25688221; Score: 0.35
DE  Interaction: P07858; IntAct: EBI-25688221; Score: 0.35
DE  Interaction: Q16719; IntAct: EBI-25688245; Score: 0.35
DE  Interaction: O43570; IntAct: EBI-25688245; Score: 0.35
DE  Interaction: Q86TG7; IntAct: EBI-25688201; Score: 0.40
DE  Interaction: P06400; IntAct: EBI-25684934; Score: 0.56
DE  Interaction: Q86WV6; IntAct: EBI-25751009; Score: 0.40
DE  Interaction: Q9UHD2; IntAct: EBI-25751044; Score: 0.40
DE  Interaction: AY394850.2; IntAct: EBI-25752076; Score: 0.44
DE  Interaction: P0C6Y0; IntAct: EBI-25758199; Score: 0.44
DE  Interaction: P0C6Y5; IntAct: EBI-25758300; Score: 0.44
DE  Interaction: Q98VG9; IntAct: EBI-25758361; Score: 0.44
DE  Interaction: P0C6Y1; IntAct: EBI-25758560; Score: 0.44
DE  Interaction: Q9Y657; IntAct: EBI-25762307; Score: 0.35
DE  Interaction: Q96K19; IntAct: EBI-25762307; Score: 0.35
DE  Interaction: Q9UBN7; IntAct: EBI-25762307; Score: 0.35
DE  Interaction: O94905; IntAct: EBI-25762307; Score: 0.35
DE  Interaction: O75477; IntAct: EBI-25762307; Score: 0.35
DE  Interaction: P51798; IntAct: EBI-25762307; Score: 0.35
DE  Interaction: Q8N4V1; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: P62699; IntAct: EBI-25762541; Score: 0.53
DE  Interaction: Q9H7D7; IntAct: EBI-25762541; Score: 0.53
DE  Interaction: Q9BQB6; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q99942; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q9H871; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q96S59; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q6VN20; IntAct: EBI-25762541; Score: 0.53
DE  Interaction: Q9UKZ9; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: O75592; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q9UL63; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q7L5Y9; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q13907; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q15011; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q9NWU2; IntAct: EBI-25762541; Score: 0.53
DE  Interaction: P0C2W1; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q9ULG6; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: P27824; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q8IUR7; IntAct: EBI-25762541; Score: 0.35
DE  Interaction: Q13557; IntAct: EBI-25825454; Score: 0.57
DE  Interaction: Q96PM5; IntAct: EBI-25825454; Score: 0.59
DE  Interaction: P04637; IntAct: EBI-25825787; Score: 0.35
DE  Interaction: Q92499; IntAct: EBI-25827273; Score: 0.40
DE  Interaction: P49643; IntAct: EBI-26376937; Score: 0.53
DE  Interaction: P49642; IntAct: EBI-26376937; Score: 0.53
DE  Interaction: P09884; IntAct: EBI-26376937; Score: 0.53
DE  Interaction: Q14181; IntAct: EBI-26376937; Score: 0.53
DE  Interaction: Q969X5; IntAct: EBI-26376953; Score: 0.35
DE  Interaction: Q6Q0C0; IntAct: EBI-26376953; Score: 0.35
DE  Interaction: O15078; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q9HCJ0; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q9HAU0; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q9H2H8; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q96M11; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q96IZ5; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q92908; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q92615; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q8IWR0; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q86SQ0; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q70EL1; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q6ZRI6; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q6UUV7; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q5VUA4; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q5EBL8; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q4KMZ1; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q2T9J0; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q2NL68; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q13948; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q13615; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q13546; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: Q13033; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: O95391; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: O75506; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: O43303; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: O15014; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: A3KN83; IntAct: EBI-26376977; Score: 0.35
DE  Interaction: P17612; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9Y2I6; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q8WWI1; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q8N4C6; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: P35579; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9Y608; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9Y4I1; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9UPQ0; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9UPN4; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9UM54; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9ULV0; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9H0E2; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9BZF9; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9BV73; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9BV19; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9BQQ3; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q99996; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q96SN8; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q96N16; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q96II8; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q92995; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q92614; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q8WXW3; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q8TD10; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q8IUD2; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q7Z406; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q6ZVM7; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q66GS9; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q5VUJ6; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q5VU43; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q5VT06; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q14789; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q13045; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q12965; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q08379; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q08378; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q04726; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q04724; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: P67936; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: P35241; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: P28289; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: P14649; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: P13861; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: P09493; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: P06396; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: O95684; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: O95613; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: O75381; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: O60784; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: O60237; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: O14908; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: O14639; IntAct: EBI-26377017; Score: 0.35
DE  Interaction: Q9NXA8; IntAct: EBI-26377088; Score: 0.35
DE  Interaction: Q96JN8; IntAct: EBI-26377088; Score: 0.35
DE  Interaction: P12268; IntAct: EBI-26377088; Score: 0.35
DE  Interaction: P06280; IntAct: EBI-26377088; Score: 0.35
DE  Interaction: O95714; IntAct: EBI-26377088; Score: 0.35
DE  Interaction: P62330; IntAct: EBI-26377105; Score: 0.40
DE  Interaction: Q9Y2S7; IntAct: EBI-26377113; Score: 0.35
DE  Interaction: Q9UKF6; IntAct: EBI-26377113; Score: 0.35
DE  Interaction: Q8TEM1; IntAct: EBI-26377113; Score: 0.35
DE  Interaction: Q5SVZ6; IntAct: EBI-26377113; Score: 0.35
DE  Interaction: Q567U6; IntAct: EBI-26377113; Score: 0.35
DE  Interaction: P28838; IntAct: EBI-26377113; Score: 0.35
DE  Interaction: O60232; IntAct: EBI-26377113; Score: 0.35
DE  Interaction: Q13347; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: P55884; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: O15371; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: Q9Y262; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: Q9UBQ5; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: Q9C037; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: Q99613; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: Q86UK7; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: Q6NUN9; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: Q14152; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: P60228; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: P52306; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: O75822; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: O15372; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: O00303; IntAct: EBI-26377128; Score: 0.35
DE  Interaction: P14735; IntAct: EBI-26377154; Score: 0.35
DE  Interaction: P07203; IntAct: EBI-26377169; Score: 0.35
DE  Interaction: Q9NXH9; IntAct: EBI-26377169; Score: 0.35
DE  Interaction: Q99720; IntAct: EBI-26377180; Score: 0.40
DE  Interaction: Q9Y3D7; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q9NYP7; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q9H7Z7; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q9BQE4; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q96KC8; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q96ER9; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q96A26; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q8WUY8; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q8WTV0; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q8NBX0; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q8IUR0; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q7LGA3; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q6ZRP7; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q6P1Q0; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q5VT66; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q2TAA5; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q12907; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: P61006; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: P00387; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: O94766; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: A8MTT3; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: Q9BSC4; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q9Y3B7; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q9NQT5; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q9NQT4; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q8NEJ9; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: P82675; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q9ULT8; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q9UL40; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q9UGI8; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q9NY61; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q9H6F5; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q96FK6; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q96B26; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q8N983; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q8IY37; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q7L2J0; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q4G0J3; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q15397; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q14692; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: Q13206; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: P09132; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: O95260; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: O76094; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: O00566; IntAct: EBI-26377216; Score: 0.35
DE  Interaction: P35556; IntAct: EBI-26377247; Score: 0.35
DE  Interaction: Q8TD19; IntAct: EBI-26377247; Score: 0.35
DE  Interaction: Q8N1G2; IntAct: EBI-26377247; Score: 0.35
DE  Interaction: Q8N0X7; IntAct: EBI-26377247; Score: 0.35
DE  Interaction: Q86YT6; IntAct: EBI-26377247; Score: 0.35
DE  Interaction: Q14232; IntAct: EBI-26377247; Score: 0.35
DE  Interaction: P61962; IntAct: EBI-26377247; Score: 0.35
DE  Interaction: O00142; IntAct: EBI-26377247; Score: 0.35
DE  Interaction: P62753; IntAct: EBI-26451065; Score: 0.40
DE  Interaction: Q64339; IntAct: EBI-26583749; Score: 0.56
DE  Interaction: P0CG48; IntAct: EBI-26585786; Score: 0.56
DE  Interaction: P31151; IntAct: EBI-26584254; Score: 0.35
DE  Interaction: P05109; IntAct: EBI-26584254; Score: 0.35
DE  Interaction: P59665; IntAct: EBI-26584254; Score: 0.35
DE  Interaction: P07339; IntAct: EBI-26584254; Score: 0.35
DE  Interaction: P47929; IntAct: EBI-26584254; Score: 0.35
DE  Interaction: Q96P63; IntAct: EBI-26584254; Score: 0.35
DE  Interaction: P48594; IntAct: EBI-26584254; Score: 0.35
DE  Interaction: P29508; IntAct: EBI-26584254; Score: 0.35
DE  Interaction: P06702; IntAct: EBI-26584254; Score: 0.35
DE  Interaction: P05161; IntAct: EBI-26584341; Score: 0.54
DE  Interaction: P25963; IntAct: EBI-26585885; Score: 0.44
DE  Interaction: Q13616; IntAct: EBI-26585276; Score: 0.44
DE  Interaction: Q9BYX4; IntAct: EBI-26895226; Score: 0.40
DE  Interaction: Q96C36; IntAct: EBI-27129499; Score: 0.46
DE  Interaction: P32322; IntAct: EBI-27129499; Score: 0.46
DE  Interaction: Q96CT2; IntAct: EBI-27128638; Score: 0.35
DE  Interaction: Q93008; IntAct: EBI-27128638; Score: 0.35
DE  Interaction: Q9HA64; IntAct: EBI-27128638; Score: 0.35
DE  Interaction: A3KMH1; IntAct: EBI-27128638; Score: 0.35
DE  Interaction: Q9UKK9; IntAct: EBI-27128638; Score: 0.35
DE  Interaction: O95071; IntAct: EBI-27128638; Score: 0.35
DE  Interaction: Q7Z4H7; IntAct: EBI-27128638; Score: 0.35
DE  Interaction: P78344; IntAct: EBI-27128638; Score: 0.35
DE  Interaction: Q96CW1; IntAct: EBI-30605858; Score: 0.40
GO  GO:0039714;
GO  GO:0062243;
GO  GO:1905369;
GO  GO:1902555;
GO  GO:1905354;
GO  GO:0030430;
GO  GO:0044165;
GO  GO:0044172;
GO  GO:0044174;
GO  GO:0044177;
GO  GO:0044220;
GO  GO:0016021;
GO  GO:0044385;
GO  GO:0031533;
GO  GO:0031381;
GO  GO:0000175;
GO  GO:0032574;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0004843;
GO  GO:0004197;
GO  GO:0003678;
GO  GO:0003725;
GO  GO:0004519;
GO  GO:0002151;
GO  GO:0004386;
GO  GO:0042802;
GO  GO:0019785;
GO  GO:0016829;
GO  GO:1990380;
GO  GO:0004482;
GO  GO:0004483;
GO  GO:0008242;
GO  GO:0046983;
GO  GO:0003968;
GO  GO:0003727;
GO  GO:0008270;
GO  GO:0006370;
GO  GO:0006351;
GO  GO:0039595;
GO  GO:0039520;
GO  GO:0039648;
GO  GO:0080009;
GO  GO:1902680;
GO  GO:2000158;
GO  GO:0045070;
GO  GO:0039690;
GO  GO:0016540;
GO  GO:0071108;
GO  GO:0070536;
GO  GO:0016485;
GO  GO:0006508;
GO  GO:0090503;
GO  GO:0001172;
GO  GO:0039657;
GO  GO:0039579;
GO  GO:0039644;
GO  GO:0039722;
GO  GO:0039547;
GO  GO:0039604;
GO  GO:0039501;
GO  GO:0039502;
GO  GO:0039548;
GO  GO:0019082;
GO  GO:0046786;
GO  GO:0039694;
GO  GO:0019083;
TP  Membrane Topology: Transmembrane; Source: UniProt - Curator Inference {ECO:0000305|PubMed:18842706};
SQ  MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGVLPQLEQPYVFIKRSDALSTN
SQ  HGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRNVLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQN
SQ  WNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW
SQ  FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNNMHLSTL
SQ  MKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKG
SQ  GRTRCFGGCVFAYVGCYNKRAYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF
SQ  SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTLDAANHSIP
SQ  DLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVE
SQ  FLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC
SQ  IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYC
SQ  ALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAV
SQ  VKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL
SQ  PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAAN
SQ  IHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQD
SQ  ILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK
SQ  PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSGDITCVVIPSK
SQ  KAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEE
SQ  TRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR
SQ  CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVE
SQ  FHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPS
SQ  DDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR
SQ  AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGV
SQ  SIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPV
SQ  TDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ
SQ  MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSN
SQ  SFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENT
SQ  SITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT
SQ  KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYC
SQ  NGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGL
SQ  SAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC
SQ  TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHL
SQ  YFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDS
SQ  TEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL
SQ  EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLT
SQ  CATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIIST
SQ  DDCFANKHAGFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI
SQ  EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEY
SQ  CRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYY
SQ  FMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI
SQ  YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDT
SQ  TSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR
SQ  HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG
SQ  SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI
SQ  TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT
SQ  ILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA
SQ  CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDD
SQ  AARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVY
SQ  CFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS
SQ  DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQA
SQ  IASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRA
SQ  KVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD
SQ  ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLA
SQ  LLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPAN
SQ  STVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC
SQ  DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNRVCGVSAARLTPCGTGTSTDVV
SQ  YRAFDIYNEKVAGFAKFLKTNCCRFQEKDEEGNLLDSYFVVKRHTMSNYQHEETIYNLVKDCPAVAVHDFFKFRVDGDMV
SQ  PHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQSLLKTVQ
SQ  FCDAMRDAGIVGVLTLDNQDLNGNWYDFGDFVQVAPGCGVPIVDSYYSLLMPILTLTRALAAESHMDADLAKPLIKWDLL
SQ  KYDFTEERLCLFDRYFKYWDQTYHPNCINCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFREL
SQ  GVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKE
SQ  GSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGK
SQ  ARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGT
SQ  SKFYGGWHNMLKTVYSDVETPHLMGWDYPKCDRAMPNMLRIMASLVLARKHNTCCNLSHRFYRLANECAQVLSEMVMCGG
SQ  SLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDHEFVDEFYAYLRK
SQ  HFSMMILSDDAVVCYNSNYAAQGLVASIKNFKAVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPY
SQ  PDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDN
SQ  TSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTD
SQ  VTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLK
SQ  ATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKL
SQ  NVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYY
SQ  PSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMA
SQ  TNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDN
SQ  KLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGS
SQ  EYDYVIFTQTTETAHSCNVNRFNVAITRAKIGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKIITGL
SQ  HPTQAPTHLSVDIKFKTEGLCVDIPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATR
SQ  DAVGTNLPLQLGFSTGVNLVAVPTGYVDTENNTEFTRVNAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKGLS
SQ  DRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDKRATCFSTSSDTYACWNHSVGFDYVYNPFMIDVQQWGFTGNLQSNHD
SQ  QHCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWSVEYPIIGDELRVNSACRKVQHMVVKSALLADKFPVLHDIGNPKAI
SQ  KCVPQAEVEWKFYDAQPCSDKAYKIEELFYSYATHHDKFTDGVCLFWNCNVDRYPANAIVCRFDTRVLSNLNLPGCDGGS
SQ  LYVNKHAFHTPAFDKSAFTNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRQYLDAY
SQ  NMMISAGFSLWIYKQFDTYNLWNTFTRLQSLENVAYNVVNKGHFDGHAGEAPVSIINNAVYTKVDGIDVEIFENKTTLPV
SQ  NVAFELWAKRNIKPVPEIKILNNLGVDIAANTVIWDYKREAPAHVSTIGVCTMTDIAKKPTESACSSLTVLFDGRVEGQV
SQ  DLFRNARNGVLITEGSVKGLTPSKGPAQASVNGVTLIGESVKTQFNYFKKVDGIIQQLPETYFTQSRDLEDFKPRSQMET
SQ  DFLELAMDEFIQRYKLEGYAFEHIVYGDFSHGQLGGLHLMIGLAKRSQDSPLKLEDFIPMDSTVKNYFITDAQTGSSKCV
SQ  CSVIDLLLDDFVEIIKSQDLSVISKVVKVTIDYAEISFMLWCKDGHVETFYPKLQASQAWQPGVAMPNLYKMQRMLLEKC
SQ  DLQNYGENAVIPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVS
SQ  DADSTLIGDCATVHTANKWDLIISDMYDPRTKHVTKENDSKEGFFTYLCGFIKQKLALGGSIAVKITEHSWNADLYKLMG
SQ  HFSWWTAFVTNVNASSSEAFLIGANYLGKPKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEN
SQ  QINDMIYSLLEKGRLIIRENNRVVVSSDILVNN
//