ID  P0C760;
PN  cap-snatching endonuclease;
GN  L;
OS  39002;
SL  Nucleus Position: SL-0382;
SL  Comments: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q9YQR5}.
DR  UNIPROT: P0C760;
DR  UNIPROT: I4EPA5;
DR  Pfam: PF04196;
DR  Pfam: PF12426;
DR  PROSITE: PS50525;
DE  Function: RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate (By similarity). During transcription, synthesizes subgenomic RNAs and assures their capping by a cap- snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. Cleaves ssRNA substrates but not DNA (By similarity). Seems to downregulate the expression of its own and heterologous mRNAs through its endonuclease activity (By similarity). {ECO:0000250|UniProtKB:Q9E005}.
DE  Reference Proteome: No;
GO  GO:0044220;
GO  GO:0004519;
GO  GO:0046872;
GO  GO:0000166;
GO  GO:0003968;
GO  GO:0075526;
GO  GO:0006351;
GO  GO:0039689;
GO  GO:0039696;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEKYRDIHERVKEAVPGETSAVECLDLLDRLYAVRHDVVDQMIKHDWSDNKDREQPIGLVLLMAGVPNDVIQSMEKRVIP
SQ  GSPSGQILRSFFKMTPDNYKITGNLIEFIEVTVTADVARGVREKILKYQGGLEFIEQLLQIEAQKGNCQSGFKIKFNVVA
SQ  VRTDGSNISTQWPSRRNEGVVQAMRLIQADINFVREHLIKNDERGALEAMFNLKFHVTGPKVRTFDIPNYRPQPLCQPIL
SQ  ENLVDYCKNWLGTDHAFAFKEVTGQRVFNVFREEEEIHASKYGHSRKPRNFLLCQISLQSPYLPSTIASDQYDTRLACSE
SQ  ILKNYPETPLQLLARDMAYKYITLDHDDIINYYNPRVYFKPTQNIKEPGTFKLNLSNMDPKSKALIDVISKDSKKGVFGE
SQ  LIDSVDVASQVQHNECSKTIEKILSDLEVNLGDVANGLDQPKKTTGVDDILRKFYDNELVKYLISVIRKTTAWHLGHLLR
SQ  DITESLIAHAGLKRSKYWSAHGYACGSVLLCILPSKSLEVAGSFIRFFTVFKEGLGLIDTDNLDSKAEIDGVSWCFSKII
SQ  SLDLNRLLALNIAFEKSLLATATWFQYYTEDQGHFPLQHALRSVFAFHFLLSVSQKMKLCAIFDNLRYLIPAVTSTYSGF
SQ  EPLIRKFFERPFKSALEVYLYGIIKVLLVSLAQNNKIRFYSRVRLLGLTVDQSTIGASGVYPSLMSRVVYKHYRSLISEA
SQ  TTCFFLFEKGLHGNLTEEAKIHLETVEWARKFREKERELGSYIMEEGYHIQDVLNNQVAVEQQLFCQEVVELAAQELNTY
SQ  LHAKSQVMASNIMNKHWDKPYFSQTRNISLKGMSGALQEDGHLAASVTLIEAIRFLNHSQNNPTVLELYEQTKKQRAQAR
SQ  IVRKYQRTEADRGFFITTLPTRVRLEIIEDYYDAIAKVVPEEYISYGGERKILNIQQALEKALRWASGESEIQSSLGHSI
SQ  KLKRKLMYVSADATKWSPGDNSAKFRRFTQSLYDGLRDDKLKNCVVDALRNIYETDFFISRKLHRYIDNMGELSDEVLDF
SQ  LSFFPNKVSASIKGNWLQGNLNKCSSLFGAAISLLFKRVWAKLYPELECFFEFAHHSDDALFIYGYLEPIDDGTEWFQYV
SQ  TQQIQAGNFHWHAVNQEMWKSMFNLHEHILLMGSIKISPKKTTVSPTNAEFLSTFFEGCAVSIPFIKILLGSLSDLPGLG
SQ  YFDDLAAAQSRCVKALDMGACPQLAQLGIVLCTSKVERLYGTAPGMVNNPTAYLKVDRNLIPIPLGGDGSMSIMELATAG
SQ  IGMADKNILKNAFITYKHAKKDNDRYVLGLFKFLMSLSDDIFQHDRLGEFSFVGKVQWKVFTPKSEFEFYDQYSRKYLEL
SQ  WSEQHPVYDYIIPRGRDNLLVYLVRKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCKLGGEWVTFREVLAAADAFASEY
SQ  RPTLQDMELFQTLVNCTFSKEYAWRDFLNEVQCDVLTTRQIHRPKVARTFTVKERDQTIQNPITAVIGYKYASKVDEISD
SQ  VLDSALHPDSLSTDLQLMREGVYRELGLDISQPNVLKKVAPLLYKSGKSRIVIVQGNVEGTAESICSYWLKTMSLVKTIK
SQ  VKPKKEVLKAVSLYGKKEKVGDLTHLAAMRLCIEVWRWCKANEQDSVTWLKYLVFENKTLEQWVDLFCSRGVLPIDPEIQ
SQ  CLGLLVYDLKGQKGLLQIQANRRAYSGKQYDAYCVQTYNEETKLYEGDLRVTFNFGIDCARLEIFWDKKEYILETSITQR
SQ  NVLKILMEEVTKELLRCGMRFKTEQVNSSRSVVLFKTESGFEWGKPNVPCIVYRNCTLRTGLRVRHPTNKAFSITIQANG
SQ  FRAMAQLDEENPRFLLAHAYHNLKDVRYQALQAVGNVWFKMTQHKLFINPIISAGLLENFMKGLPAAIPPAAYSLIMNKA
SQ  KISVDLFMFNELLALINPQNVLNLDGIEETSEGFTTVSTISSTQWSEEVSLTLDDSDDDDDASNLDYTIDLDDIDFETID
SQ  LKEDIEHFLQDESAYTGDLLIQTEETEVRKLRGMIKILEPVKLIKSWVSKGLSIDKIYNPVNIILMTRYMSKHYNFQAKQ
SQ  LSLMDPYDLTEFESVVKGWGECVKDRFIELDQEAQRKVTEERVLPEDVLPDSFFSFRHADILLKRLFPRDSASSFY
//