ID  P0DTC7;
PN  ORF7a protein;
GN  7a;
OS  2697049;
SL  Nucleus Position: SL-0382;
SL  Comments: Host cytoplasm, host perinuclear region {ECO:0000269|PubMed:33930332}. Virion {ECO:0000250|UniProtKB:P59635}. Host endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P59635}; Single-pass membrane protein {ECO:0000250|UniProtKB:P59635}. Host endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:P59635}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P59635}. Host Golgi apparatus membrane {ECO:0000250|UniProtKB:P59635}; Single-pass membrane protein {ECO:0000250|UniProtKB:P59635}.
DR  UNIPROT: P0DTC7;
DR  PDB: 6W37;
DR  PDB: 7CI3;
DR  Pfam: PF08779;
DR  PROSITE: PS51919;
DE  Function: Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. Acts by binding to BST2 and sequestering it to perinuclear region, thereby preventing its antiviral function at cell membrane. {ECO:0000269|PubMed:33930332}.
DE  Reference Proteome: Yes;
DE  Interaction: O15027; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q9NU22; IntAct: EBI-25491332; Score: 0.64
DE  Interaction: Q7Z4Q2; IntAct: EBI-25491332; Score: 0.53
DE  Interaction: P0DTD1; IntAct: EBI-25508859; Score: 0.62
DE  Interaction: P30153; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P06576; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P40939; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q8IXB1; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q9UHI6; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: O95816; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P53007; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q96EY1; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P50402; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: O43852; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q9H936; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P62195; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P30876; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q99615; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P55786; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P57678; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q00325; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: O75746; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P34932; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q15008; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q9UNM6; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: O95071; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: O60884; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P62191; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P05023; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P51665; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P53618; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q9NZ01; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P35998; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q13200; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P53621; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q5H9R7; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P16615; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q99460; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: O43592; IntAct: EBI-25510184; Score: 0.53
DE  Interaction: Q9NXS2; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P46379; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q16891; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: O95347; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: P35606; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q9UBF2; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q9P035; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: O14980; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: Q96CS3; IntAct: EBI-25510184; Score: 0.35
DE  Interaction: O60784; IntAct: EBI-26495729; Score: 0.35
DE  Interaction: Q9Y5K5; IntAct: EBI-26495729; Score: 0.35
DE  Interaction: Q13535; IntAct: EBI-26495729; Score: 0.53
DE  Interaction: Q9Y385; IntAct: EBI-26495729; Score: 0.35
DE  Interaction: Q6NUT2; IntAct: EBI-26495729; Score: 0.35
DE  Interaction: Q13586; IntAct: EBI-26495729; Score: 0.35
DE  Interaction: P14314; IntAct: EBI-26495729; Score: 0.35
DE  Interaction: P42858; IntAct: EBI-26495729; Score: 0.35
DE  Interaction: P48741; IntAct: EBI-26495729; Score: 0.35
DE  Interaction: Q13315; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9H0H0; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q6P9B9; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9Y6D6; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9Y617; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9UI26; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9UI09; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9NVI1; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9HD20; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9HAV4; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9H9P8; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9H7D0; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9H6E5; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9H0V1; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9BXW9; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q9BSE5; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q96JJ3; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q96JB2; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q96HW7; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q96CB8; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q8WTW3; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q8TB37; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q8NCM8; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q8N9R8; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q8N201; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q8N1F8; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q8N1F7; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q86XI2; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q86UT6; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q75QN2; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q70CQ2; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q6YHU6; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q6P3X3; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q63HN8; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q5UIP0; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q5SRE5; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q53R41; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q29RF7; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q15386; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q14746; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: Q01813; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: P83436; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: P42695; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: P21359; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: P11498; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: P04181; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: O95759; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: O94822; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: O75063; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: O60518; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: O43156; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: O14981; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: P0DTC7; IntAct: EBI-27121790; Score: 0.37
DE  Interaction: P0DTC5; IntAct: EBI-27121890; Score: 0.37
DE  Interaction: P0DTD8; IntAct: EBI-27121899; Score: 0.37
DE  Interaction: P43353; IntAct: EBI-27127130; Score: 0.40
DE  Interaction: P31639; IntAct: EBI-27128324; Score: 0.27
DE  Interaction: Q10589; IntAct: EBI-28948095; Score: 0.40
GO  GO:0044167;
GO  GO:0044173;
GO  GO:0044178;
GO  GO:0044220;
GO  GO:0016021;
GO  GO:0055036;
GO  GO:0039646;
GO  GO:0039587;
GO  GO:0039502;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQFAFACPDGVKHVYQLRAR
SQ  SVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKTE
//