ID  P10415;
PN  Apoptosis regulator Bcl-2;
GN  BCL2;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Mitochondrion outer membrane {ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P10417}.
DR  UNIPROT: P10415;
DR  UNIPROT: C9JHD5;
DR  UNIPROT: P10416;
DR  UNIPROT: Q13842;
DR  UNIPROT: Q16197;
DR  PDB: 1G5M;
DR  PDB: 1GJH;
DR  PDB: 1YSW;
DR  PDB: 2O21;
DR  PDB: 2O22;
DR  PDB: 2O2F;
DR  PDB: 2W3L;
DR  PDB: 2XA0;
DR  PDB: 4AQ3;
DR  PDB: 4IEH;
DR  PDB: 4LVT;
DR  PDB: 4LXD;
DR  PDB: 4MAN;
DR  PDB: 5AGW;
DR  PDB: 5AGX;
DR  PDB: 5FCG;
DR  PDB: 5JSN;
DR  PDB: 5VAU;
DR  PDB: 5VAX;
DR  PDB: 5VAY;
DR  PDB: 6GL8;
DR  PDB: 6IWB;
DR  PDB: 6O0K;
DR  PDB: 6O0L;
DR  PDB: 6O0M;
DR  PDB: 6O0O;
DR  PDB: 6O0P;
DR  PDB: 7LHB;
DR  Pfam: PF00452;
DR  Pfam: PF02180;
DR  PROSITE: PS50062;
DR  PROSITE: PS01080;
DR  PROSITE: PS01258;
DR  PROSITE: PS01259;
DR  PROSITE: PS01260;
DR  PROSITE: PS50063;
DR  OMIM: 151430;
DR  DisGeNET: 596;
DE  Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:21358617, PubMed:20889974). May attenuate inflammation by impairing NLRP1- inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:1508712, ECO:0000269|PubMed:17418785, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:8183370, ECO:0000303|PubMed:11368354}.
DE  Disease: Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. {ECO:0000269|PubMed:2875799, ECO:0000269|PubMed:3285301}.
DE  Reference Proteome: Yes;
DE  Interaction: O60238; IntAct: EBI-850662; Score: 0.44
DE  Interaction: O54918; IntAct: EBI-707531; Score: 0.44
DE  Interaction: Q9DAJ5; IntAct: EBI-526356; Score: 0.35
DE  Interaction: P51572; IntAct: EBI-77682; Score: 0.52
DE  Interaction: P28482; IntAct: EBI-7210282; Score: 0.49
DE  Interaction: P67775; IntAct: EBI-7210303; Score: 0.49
DE  Interaction: P45983; IntAct: EBI-7497436; Score: 0.31
DE  Interaction: Q14318; IntAct: EBI-7497544; Score: 0.51
DE  Interaction: P55957; IntAct: EBI-519684; Score: 0.87
DE  Interaction: Q9BXH1; IntAct: EBI-707957; Score: 0.82
DE  Interaction: P63098; IntAct: EBI-7517885; Score: 0.49
DE  Interaction: Q07813; IntAct: EBI-700706; Score: 0.40
DE  Interaction: Q07812; IntAct: EBI-700753; Score: 0.94
DE  Interaction: Q16611; IntAct: EBI-700762; Score: 0.61
DE  Interaction: Q92934; IntAct: EBI-700785; Score: 0.81
DE  Interaction: Q13323; IntAct: EBI-700803; Score: 0.82
DE  Interaction: P10415; IntAct: EBI-700826; Score: 0.59
DE  Interaction: O43521; IntAct: EBI-707839; Score: 0.92
DE  Interaction: Q91ZE9; IntAct: EBI-708044; Score: 0.62
DE  Interaction: Q61337; IntAct: EBI-709166; Score: 0.72
DE  Interaction: Q12982; IntAct: EBI-849945; Score: 0.37
DE  Interaction: Q12983; IntAct: EBI-849952; Score: 0.37
DE  Interaction: O60551; IntAct: EBI-8173465; Score: 0.40
DE  Interaction: Q63690; IntAct: EBI-8496082; Score: 0.40
DE  Interaction: P62136; IntAct: EBI-1206840; Score: 0.00
DE  Interaction: P36873; IntAct: EBI-1207036; Score: 0.00
DE  Interaction: P62140; IntAct: EBI-1207176; Score: 0.00
DE  Interaction: Q86Y07; IntAct: EBI-1207847; Score: 0.37
DE  Interaction: Q9C000; IntAct: EBI-1246113; Score: 0.75
DE  Interaction: Q14457; IntAct: EBI-5234827; Score: 0.95
DE  Interaction: Q9H2V7; IntAct: EBI-1386538; Score: 0.46
DE  Interaction: O15304; IntAct: EBI-1393040; Score: 0.40
DE  Interaction: Q14790; IntAct: EBI-1749080; Score: 0.37
DE  Interaction: P22736; IntAct: EBI-2126295; Score: 0.67
DE  Interaction: Q07817; IntAct: EBI-2126646; Score: 0.44
DE  Interaction: P04637; IntAct: EBI-7044574; Score: 0.56
DE  Interaction: O15151; IntAct: EBI-7044604; Score: 0.50
DE  Interaction: Q8N5K1; IntAct: EBI-7676229; Score: 0.54
DE  Interaction: Q0WGQ5; IntAct: EBI-2874959; Score: 0.00
DE  Interaction: P27797; IntAct: EBI-8537109; Score: 0.35
DE  Interaction: P38646; IntAct: EBI-8537109; Score: 0.35
DE  Interaction: Q07820; IntAct: EBI-8537109; Score: 0.35
DE  Interaction: Q9C0C7; IntAct: EBI-8600088; Score: 0.66
DE  Interaction: Q13794; IntAct: EBI-4370379; Score: 0.54
DE  Interaction: Q96LC9; IntAct: EBI-5488187; Score: 0.40
DE  Interaction: P29117; IntAct: EBI-6465503; Score: 0.40
DE  Interaction: P30405; IntAct: EBI-6465542; Score: 0.37
DE  Interaction: Q9NYF8; IntAct: EBI-6621256; Score: 0.50
DE  Interaction: P38398; IntAct: EBI-8757170; Score: 0.38
DE  Interaction: P0DM65; IntAct: EBI-8839562; Score: 0.40
DE  Interaction: A8MW95; IntAct: EBI-8839552; Score: 0.40
DE  Interaction: Q5S007; IntAct: EBI-10055396; Score: 0.44
DE  Interaction: Q7L3V2; IntAct: EBI-11509550; Score: 0.35
DE  Interaction: Q13625; IntAct: EBI-15723849; Score: 0.65
DE  Interaction: P11881; IntAct: EBI-15801106; Score: 0.52
DE  Interaction: Q14643; IntAct: EBI-15801089; Score: 0.40
DE  Interaction: P21796; IntAct: EBI-15801214; Score: 0.40
DE  Interaction: Q92570; IntAct: EBI-20939354; Score: 0.40
DE  Interaction: P59635; IntAct: EBI-25495801; Score: 0.40
DE  Interaction: P00441; IntAct: EBI-25934648; Score: 0.56
DE  Interaction: P05067; IntAct: EBI-25936674; Score: 0.56
DE  Interaction: Q9HB09; IntAct: EBI-27086233; Score: 0.37
DE  Interaction: Q13619; IntAct: EBI-30863570; Score: 0.35
DE  Interaction: Q8WV16; IntAct: EBI-30863977; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016020;
GO  GO:0005741;
GO  GO:0005739;
GO  GO:0043209;
GO  GO:0031965;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0046930;
GO  GO:0032991;
GO  GO:0051434;
GO  GO:0015267;
GO  GO:0016248;
GO  GO:0140297;
GO  GO:0042802;
GO  GO:0060090;
GO  GO:0002020;
GO  GO:0046982;
GO  GO:0042803;
GO  GO:0051721;
GO  GO:0043565;
GO  GO:0031625;
GO  GO:0007015;
GO  GO:0006915;
GO  GO:0031103;
GO  GO:0007409;
GO  GO:0001783;
GO  GO:0001782;
GO  GO:0002326;
GO  GO:0042100;
GO  GO:0050853;
GO  GO:0001662;
GO  GO:0001658;
GO  GO:0060402;
GO  GO:0043375;
GO  GO:0098609;
GO  GO:0006974;
GO  GO:0042149;
GO  GO:0071456;
GO  GO:0071310;
GO  GO:0021747;
GO  GO:0051607;
GO  GO:0097048;
GO  GO:0048546;
GO  GO:0043583;
GO  GO:0032469;
GO  GO:1904019;
GO  GO:0097192;
GO  GO:0008625;
GO  GO:0007565;
GO  GO:0048041;
GO  GO:0000082;
GO  GO:0022612;
GO  GO:0032835;
GO  GO:0031069;
GO  GO:0060218;
GO  GO:0048873;
GO  GO:0006959;
GO  GO:0008630;
GO  GO:0070059;
GO  GO:0008631;
GO  GO:0002320;
GO  GO:0008584;
GO  GO:0006582;
GO  GO:0030318;
GO  GO:0014031;
GO  GO:0001656;
GO  GO:0097049;
GO  GO:0033028;
GO  GO:2000811;
GO  GO:0043066;
GO  GO:2001234;
GO  GO:0010507;
GO  GO:0002903;
GO  GO:0010523;
GO  GO:0030308;
GO  GO:0030336;
GO  GO:0032848;
GO  GO:2000669;
GO  GO:1904036;
GO  GO:2001240;
GO  GO:2000134;
GO  GO:2001243;
GO  GO:1902166;
GO  GO:0051902;
GO  GO:2000672;
GO  GO:0033033;
GO  GO:0043524;
GO  GO:0030279;
GO  GO:0033689;
GO  GO:2000378;
GO  GO:0046671;
GO  GO:0070233;
GO  GO:0051402;
GO  GO:0042551;
GO  GO:0048599;
GO  GO:0035265;
GO  GO:0001503;
GO  GO:0033687;
GO  GO:0001541;
GO  GO:0018105;
GO  GO:0018107;
GO  GO:0048753;
GO  GO:0030890;
GO  GO:0043085;
GO  GO:0030307;
GO  GO:0008284;
GO  GO:0045636;
GO  GO:0040018;
GO  GO:0014042;
GO  GO:0033138;
GO  GO:0048743;
GO  GO:0014911;
GO  GO:0009791;
GO  GO:0006470;
GO  GO:0000209;
GO  GO:0072593;
GO  GO:0051924;
GO  GO:0001952;
GO  GO:0010468;
GO  GO:0010559;
GO  GO:0046902;
GO  GO:0051881;
GO  GO:0006808;
GO  GO:0032880;
GO  GO:0031647;
GO  GO:0022898;
GO  GO:0045069;
GO  GO:0001836;
GO  GO:0003014;
GO  GO:0034097;
GO  GO:0010332;
GO  GO:0051384;
GO  GO:0042542;
GO  GO:0010039;
GO  GO:0002931;
GO  GO:1904373;
GO  GO:0035094;
GO  GO:0009314;
GO  GO:0009636;
GO  GO:0010224;
GO  GO:0009410;
GO  GO:0046666;
GO  GO:0048741;
GO  GO:0014909;
GO  GO:0048536;
GO  GO:0048864;
GO  GO:0070231;
GO  GO:0033077;
GO  GO:0043029;
GO  GO:0048538;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGA
SQ  AAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVE
SQ  SVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
//