ID  P11017;
PN  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;
GN  GNB2;
OS  9913;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P62879}. Cell membrane {ECO:0000250|UniProtKB:P62879}.
DR  UNIPROT: P11017;
DR  UNIPROT: A5D7A9;
DR  Pfam: PF00400;
DR  PROSITE: PS00678;
DR  PROSITE: PS50082;
DR  PROSITE: PS50294;
DE  Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005834;
GO  GO:0048471;
GO  GO:0003924;
GO  GO:0051020;
GO  GO:0044877;
GO  GO:0030159;
GO  GO:0007186;
GO  GO:1901379;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI
SQ  IWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS
SQ  SGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA
SQ  FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGV
SQ  TDDGMAVATGSWDSFLKIWN
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