ID  P14069;
PN  Protein S100-A6;
GN  S100a6;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Comments: Nucleus envelope {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
DR  UNIPROT: P14069;
DR  PDB: 4P2Y;
DR  Pfam: PF01023;
DR  PROSITE: PS00018;
DR  PROSITE: PS50222;
DR  PROSITE: PS00303;
DE  Function: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: P30416; IntAct: EBI-7835551; Score: 0.35
DE  Interaction: Q08752; IntAct: EBI-7835551; Score: 0.35
DE  Interaction: Q9CXW3; IntAct: EBI-6478783; Score: 0.65
DE  Interaction: A0A0F6B423; IntAct: EBI-13953902; Score: 0.35
GO  GO:0062023;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0031234;
GO  GO:0005635;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0001726;
GO  GO:0005509;
GO  GO:0048306;
GO  GO:0015075;
GO  GO:0042803;
GO  GO:0044548;
GO  GO:0005523;
GO  GO:0008270;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250};
SQ  MACPLDQAIGLLVAIFHKYSGKEGDKHTLSKKELKELIQKELTIGSKLQDAEIARLMDDLDRNKDQEVNFQEYVAFLGAL
SQ  ALIYNEALK
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