ID  P14142;
PN  Solute carrier family 2, facilitated glucose transporter member 4;
GN  Slc2a4;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000269|PubMed:21907143, ECO:0000269|PubMed:25586176, ECO:0000269|PubMed:26240143, ECO:0000269|PubMed:26629404, ECO:0000269|PubMed:27739494}; Multi-pass membrane protein {ECO:0000269|PubMed:21907143}. Endomembrane system {ECO:0000269|PubMed:26240143, ECO:0000269|PubMed:26629404}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:26240143, ECO:0000269|PubMed:26629404, ECO:0000269|PubMed:27354378}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:26629404, PubMed:26240143, PubMed:27354378). The dileucine internalization motif is critical for intracellular sequestration (PubMed:26240143, PubMed:26629404). Insulin stimulation induces translocation to the cell membrane (PubMed:27739494). {ECO:0000269|PubMed:26240143, ECO:0000269|PubMed:26629404, ECO:0000269|PubMed:27354378, ECO:0000269|PubMed:27739494}.
DR  UNIPROT: P14142;
DR  UNIPROT: Q3TPK6;
DR  UNIPROT: Q9JJN9;
DR  Pfam: PF00083;
DR  PROSITE: PS50850;
DR  PROSITE: PS00216;
DR  PROSITE: PS00217;
DE  Function: Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation (PubMed:26240143, PubMed:26629404). Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells (PubMed:26240143, PubMed:26629404). Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell (PubMed:26240143, PubMed:26629404). {ECO:0000269|PubMed:26240143, ECO:0000269|PubMed:26629404}.
DE  Disease: Note=Defects in Slc2a4 may be the cause of certain post- receptor defects in non-insulin-dependent diabetes mellitus (NIDDM).
DE  Reference Proteome: Yes;
DE  Interaction: Q6P5E6; IntAct: EBI-7540254; Score: 0.46
DE  Interaction: Q3U7R1; IntAct: EBI-15762008; Score: 0.50
GO  GO:0009986;
GO  GO:0005905;
GO  GO:0030136;
GO  GO:0005737;
GO  GO:0030659;
GO  GO:0005829;
GO  GO:0012505;
GO  GO:0005768;
GO  GO:0009897;
GO  GO:0070062;
GO  GO:0032593;
GO  GO:0016021;
GO  GO:0005887;
GO  GO:0043231;
GO  GO:0016020;
GO  GO:0045121;
GO  GO:0005771;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0098793;
GO  GO:0042383;
GO  GO:0016529;
GO  GO:0030315;
GO  GO:0005802;
GO  GO:0030140;
GO  GO:0031982;
GO  GO:0012506;
GO  GO:0055056;
GO  GO:0005355;
GO  GO:0015304;
GO  GO:0015149;
GO  GO:0005360;
GO  GO:0010021;
GO  GO:0050873;
GO  GO:0071456;
GO  GO:0032869;
GO  GO:0071470;
GO  GO:0071356;
GO  GO:0042593;
GO  GO:0046323;
GO  GO:0044381;
GO  GO:1904659;
GO  GO:0007611;
GO  GO:0007616;
GO  GO:0015749;
GO  GO:0031550;
GO  GO:0098694;
GO  GO:0045471;
GO  GO:0007614;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MPSGFQQIGSDDGEPPRQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSIPQGTLTTL
SQ  WALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYV
SQ  GEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPA
SQ  RKSLKRLTGWADVSDALAELKDEKRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVG
SQ  QPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPG
SQ  PIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQIS
SQ  AAFRRTPSLLEQEVKPSTELEYLGPDEND
//