ID  P14906;
PN  Protein translocation protein SEC63;
GN  SEC63;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein.
DR  UNIPROT: P14906;
DR  UNIPROT: D6W2V5;
DR  UNIPROT: Q08690;
DR  PDB: 6N3Q;
DR  PDB: 6ND1;
DR  PDB: 7AFT;
DR  PDB: 7KAH;
DR  PDB: 7KAI;
DR  PDB: 7KAJ;
DR  PDB: 7KAO;
DR  PDB: 7KAP;
DR  PDB: 7KAQ;
DR  PDB: 7KAR;
DR  PDB: 7KAS;
DR  PDB: 7KAT;
DR  PDB: 7KAU;
DR  PDB: 7KB5;
DR  Pfam: PF00226;
DR  PROSITE: PS00636;
DR  PROSITE: PS50076;
DE  Function: Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC63 may affect SEC1-polypeptide interactions by increasing the affinity of targeting pathways for SEC61 and/or by modifying SEC61 to allow more efficient polypeptide interaction. May also be involved in SRP-dependent cotranslational translocation. Is essential for cell growth and for germination. {ECO:0000269|PubMed:11226176}.
DE  Reference Proteome: Yes;
DE  Interaction: P30605; IntAct: EBI-7743571; Score: 0.37
DE  Interaction: P39742; IntAct: EBI-7750338; Score: 0.83
DE  Interaction: P04817; IntAct: EBI-7750372; Score: 0.37
DE  Interaction: P33754; IntAct: EBI-7750388; Score: 0.83
DE  Interaction: P40073; IntAct: EBI-7757792; Score: 0.37
DE  Interaction: P33767; IntAct: EBI-7757893; Score: 0.37
DE  Interaction: P16151; IntAct: EBI-7758032; Score: 0.37
DE  Interaction: P25621; IntAct: EBI-7758150; Score: 0.37
DE  Interaction: P38353; IntAct: EBI-7758268; Score: 0.37
DE  Interaction: P38298; IntAct: EBI-7758389; Score: 0.37
DE  Interaction: P38079; IntAct: EBI-7758511; Score: 0.37
DE  Interaction: P16140; IntAct: EBI-797191; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-797191; Score: 0.35
DE  Interaction: P21825; IntAct: EBI-797191; Score: 0.75
DE  Interaction: P32629; IntAct: EBI-819187; Score: 0.27
DE  Interaction: Q02159; IntAct: EBI-860869; Score: 0.00
DE  Interaction: P47026; IntAct: EBI-853504; Score: 0.35
DE  Interaction: P40217; IntAct: EBI-7678715; Score: 0.56
DE  Interaction: P16474; IntAct: EBI-966961; Score: 0.40
DE  Interaction: P32447; IntAct: EBI-3665462; Score: 0.35
DE  Interaction: P30822; IntAct: EBI-3665470; Score: 0.35
DE  Interaction: P14922; IntAct: EBI-3665478; Score: 0.35
DE  Interaction: P39704; IntAct: EBI-3665486; Score: 0.35
DE  Interaction: P21268; IntAct: EBI-3665494; Score: 0.35
DE  Interaction: P00927; IntAct: EBI-3665502; Score: 0.35
DE  Interaction: P50946; IntAct: EBI-3665510; Score: 0.35
DE  Interaction: Q12524; IntAct: EBI-3665518; Score: 0.35
DE  Interaction: P54885; IntAct: EBI-3665526; Score: 0.35
DE  Interaction: P06103; IntAct: EBI-3665534; Score: 0.35
DE  Interaction: P40016; IntAct: EBI-3665542; Score: 0.35
DE  Interaction: Q12250; IntAct: EBI-3665550; Score: 0.35
DE  Interaction: Q05543; IntAct: EBI-3665558; Score: 0.35
DE  Interaction: O94742; IntAct: EBI-3665566; Score: 0.35
DE  Interaction: P31376; IntAct: EBI-3665574; Score: 0.35
DE  Interaction: P38326; IntAct: EBI-3665582; Score: 0.35
DE  Interaction: P38123; IntAct: EBI-3665590; Score: 0.35
DE  Interaction: Q05471; IntAct: EBI-3665598; Score: 0.35
DE  Interaction: Q04067; IntAct: EBI-3665606; Score: 0.35
DE  Interaction: Q05946; IntAct: EBI-3665614; Score: 0.35
DE  Interaction: P34110; IntAct: EBI-3665622; Score: 0.35
DE  Interaction: P16521; IntAct: EBI-3665630; Score: 0.35
DE  Interaction: P53719; IntAct: EBI-3665638; Score: 0.35
DE  Interaction: P53740; IntAct: EBI-3665646; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3665654; Score: 0.35
DE  Interaction: P38788; IntAct: EBI-3665662; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3701587; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3733411; Score: 0.35
DE  Interaction: P39079; IntAct: EBI-3740483; Score: 0.35
DE  Interaction: P37898; IntAct: EBI-3769653; Score: 0.35
DE  Interaction: Q12168; IntAct: EBI-3769661; Score: 0.35
DE  Interaction: P60010; IntAct: EBI-3769669; Score: 0.35
DE  Interaction: P22108; IntAct: EBI-3769677; Score: 0.35
DE  Interaction: P08566; IntAct: EBI-3769687; Score: 0.35
DE  Interaction: Q06834; IntAct: EBI-3769695; Score: 0.35
DE  Interaction: Q08347; IntAct: EBI-3769703; Score: 0.35
DE  Interaction: Q07457; IntAct: EBI-3769711; Score: 0.35
DE  Interaction: P00549; IntAct: EBI-3769719; Score: 0.35
DE  Interaction: Q12018; IntAct: EBI-3769727; Score: 0.35
DE  Interaction: Q06697; IntAct: EBI-3769735; Score: 0.35
DE  Interaction: P53197; IntAct: EBI-3769743; Score: 0.35
DE  Interaction: P40094; IntAct: EBI-3769751; Score: 0.35
DE  Interaction: Q01454; IntAct: EBI-3769759; Score: 0.35
DE  Interaction: P38865; IntAct: EBI-3769767; Score: 0.35
DE  Interaction: P31373; IntAct: EBI-3769775; Score: 0.35
DE  Interaction: P32582; IntAct: EBI-3769783; Score: 0.35
DE  Interaction: Q08496; IntAct: EBI-3769791; Score: 0.35
DE  Interaction: P53759; IntAct: EBI-3769799; Score: 0.35
DE  Interaction: Q06053; IntAct: EBI-3769807; Score: 0.35
DE  Interaction: P38737; IntAct: EBI-3769815; Score: 0.35
DE  Interaction: P36053; IntAct: EBI-3769823; Score: 0.35
DE  Interaction: P00924; IntAct: EBI-3769831; Score: 0.35
DE  Interaction: P00925; IntAct: EBI-3769839; Score: 0.35
DE  Interaction: P45976; IntAct: EBI-3769847; Score: 0.35
DE  Interaction: P15442; IntAct: EBI-3769855; Score: 0.35
DE  Interaction: Q12680; IntAct: EBI-3769863; Score: 0.35
DE  Interaction: P32347; IntAct: EBI-3769871; Score: 0.35
DE  Interaction: P28241; IntAct: EBI-3769879; Score: 0.35
DE  Interaction: P53982; IntAct: EBI-3769887; Score: 0.35
DE  Interaction: P47170; IntAct: EBI-3769895; Score: 0.35
DE  Interaction: P32361; IntAct: EBI-3769903; Score: 0.35
DE  Interaction: P48526; IntAct: EBI-3769911; Score: 0.35
DE  Interaction: P38144; IntAct: EBI-3769919; Score: 0.35
DE  Interaction: Q12494; IntAct: EBI-3769927; Score: 0.35
DE  Interaction: P38853; IntAct: EBI-3769935; Score: 0.35
DE  Interaction: Q02574; IntAct: EBI-3769943; Score: 0.35
DE  Interaction: P00958; IntAct: EBI-3769951; Score: 0.35
DE  Interaction: Q07980; IntAct: EBI-3769959; Score: 0.35
DE  Interaction: Q02455; IntAct: EBI-3769967; Score: 0.35
DE  Interaction: P40457; IntAct: EBI-3769975; Score: 0.35
DE  Interaction: P48563; IntAct: EBI-3769983; Score: 0.35
DE  Interaction: P30775; IntAct: EBI-3769991; Score: 0.35
DE  Interaction: P53166; IntAct: EBI-3769999; Score: 0.35
DE  Interaction: Q02950; IntAct: EBI-3770007; Score: 0.35
DE  Interaction: P47047; IntAct: EBI-3770015; Score: 0.35
DE  Interaction: P19524; IntAct: EBI-3770023; Score: 0.35
DE  Interaction: P33420; IntAct: EBI-3770031; Score: 0.35
DE  Interaction: Q01560; IntAct: EBI-3770039; Score: 0.35
DE  Interaction: P38271; IntAct: EBI-3770047; Score: 0.35
DE  Interaction: Q12451; IntAct: EBI-3770055; Score: 0.35
DE  Interaction: P40960; IntAct: EBI-3770063; Score: 0.35
DE  Interaction: P17558; IntAct: EBI-3770071; Score: 0.35
DE  Interaction: P40433; IntAct: EBI-3770079; Score: 0.35
DE  Interaction: P00560; IntAct: EBI-3770087; Score: 0.35
DE  Interaction: P36093; IntAct: EBI-3770095; Score: 0.35
DE  Interaction: P07271; IntAct: EBI-3770103; Score: 0.35
DE  Interaction: P33334; IntAct: EBI-3770111; Score: 0.35
DE  Interaction: P52489; IntAct: EBI-3770119; Score: 0.35
DE  Interaction: P38344; IntAct: EBI-3770127; Score: 0.35
DE  Interaction: P29539; IntAct: EBI-3770135; Score: 0.35
DE  Interaction: P53552; IntAct: EBI-3770143; Score: 0.35
DE  Interaction: P05748; IntAct: EBI-3770151; Score: 0.35
DE  Interaction: P54780; IntAct: EBI-3770159; Score: 0.35
DE  Interaction: P05749; IntAct: EBI-3770167; Score: 0.35
DE  Interaction: Q12149; IntAct: EBI-3770175; Score: 0.35
DE  Interaction: Q02206; IntAct: EBI-3770183; Score: 0.35
DE  Interaction: P40482; IntAct: EBI-3770191; Score: 0.35
DE  Interaction: P11075; IntAct: EBI-3770207; Score: 0.35
DE  Interaction: P34223; IntAct: EBI-3770223; Score: 0.35
DE  Interaction: Q06315; IntAct: EBI-3770231; Score: 0.35
DE  Interaction: P39928; IntAct: EBI-3770239; Score: 0.35
DE  Interaction: P32908; IntAct: EBI-3770247; Score: 0.35
DE  Interaction: P25357; IntAct: EBI-3770255; Score: 0.35
DE  Interaction: P36126; IntAct: EBI-3770263; Score: 0.35
DE  Interaction: P25567; IntAct: EBI-3770271; Score: 0.35
DE  Interaction: P36085; IntAct: EBI-3770280; Score: 0.35
DE  Interaction: P08153; IntAct: EBI-3770288; Score: 0.35
DE  Interaction: Q06510; IntAct: EBI-3770296; Score: 0.35
DE  Interaction: P00359; IntAct: EBI-3770304; Score: 0.35
DE  Interaction: P02994; IntAct: EBI-3770312; Score: 0.35
DE  Interaction: P32367; IntAct: EBI-3770320; Score: 0.35
DE  Interaction: P35169; IntAct: EBI-3770336; Score: 0.35
DE  Interaction: P40061; IntAct: EBI-3770344; Score: 0.35
DE  Interaction: P53874; IntAct: EBI-3770352; Score: 0.35
DE  Interaction: P07259; IntAct: EBI-3770360; Score: 0.35
DE  Interaction: P34241; IntAct: EBI-3770368; Score: 0.35
DE  Interaction: Q12339; IntAct: EBI-3770376; Score: 0.35
DE  Interaction: Q06685; IntAct: EBI-3770384; Score: 0.35
DE  Interaction: P22203; IntAct: EBI-3770392; Score: 0.35
DE  Interaction: O13584; IntAct: EBI-3770400; Score: 0.35
DE  Interaction: P33301; IntAct: EBI-3770408; Score: 0.35
DE  Interaction: P19880; IntAct: EBI-3770416; Score: 0.35
DE  Interaction: O13527; IntAct: EBI-3770424; Score: 0.35
DE  Interaction: P87264; IntAct: EBI-3770435; Score: 0.35
DE  Interaction: P39991; IntAct: EBI-3770443; Score: 0.35
DE  Interaction: P38854; IntAct: EBI-3770451; Score: 0.35
DE  Interaction: P34246; IntAct: EBI-3770459; Score: 0.35
DE  Interaction: Q05948; IntAct: EBI-3770467; Score: 0.35
DE  Interaction: Q06567; IntAct: EBI-3770475; Score: 0.35
DE  Interaction: Q03153; IntAct: EBI-3770483; Score: 0.35
DE  Interaction: Q12751; IntAct: EBI-3770491; Score: 0.35
DE  Interaction: P42842; IntAct: EBI-3770499; Score: 0.35
DE  Interaction: Q12697; IntAct: EBI-3770513; Score: 0.35
DE  Interaction: Q08748; IntAct: EBI-3770521; Score: 0.35
DE  Interaction: Q06813; IntAct: EBI-3770529; Score: 0.35
DE  Interaction: P36019; IntAct: EBI-3770537; Score: 0.35
DE  Interaction: P31111; IntAct: EBI-3770545; Score: 0.35
DE  Interaction: P32915; IntAct: EBI-9352295; Score: 0.79
GO  GO:0005783;
GO  GO:0016021;
GO  GO:0005739;
GO  GO:0005637;
GO  GO:0030867;
GO  GO:0031207;
GO  GO:0071256;
GO  GO:0008320;
GO  GO:0046967;
GO  GO:0006620;
GO  GO:0031204;
GO  GO:0006614;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MPTNYEYDEASETWPSFILTGLLMVVGPMTLLQIYQIFFGANAEDGNSGKSKEFNEEVFKNLNEEYTSDEIKQFRRKFDK
SQ  NSNKKSKIWSRRNIIIIVGWILVAILLQRINSNDAIKDAATKLFDPYEILGISTSASDRDIKSAYRKLSVKFHPDKLAKG
SQ  LTPDEKSVMEETYVQITKAYESLTDELVRQNYLKYGHPDGPQSTSHGIALPRFLVDGSASPLLVVCYVALLGLILPYFVS
SQ  RWWARTQSYTKKGIHNVTASNFVSNLVNYKPSEIVTTDLILHWLSFAHEFKQFFPDLQPTDFEKLLQDHINRRDSGKLNN
SQ  AKFRIVAKCHSLLHGLLDIACGFRNLDIALGAINTFKCIVQAVPLTPNCQILQLPNVDKEHFITKTGDIHTLGKLFTLED
SQ  AKIGEVLGIKDQAKLNETLRVASHIPNLKIIKADFLVPGENQVTPSSTPYISLKVLVRSAKQPLIPTSLIPEENLTEPQD
SQ  FESQRDPFAMMSKQPLVPYSFAPFFPTKRRGSWCCLVSSQKDGKILQTPIIIEKLSYKNLNDDKDFFDKRIKMDLTKHEK
SQ  FDINDWEIGTIKIPLGQPAPETVGDFFFRVIVKSTDYFTTDLDITMNMKVRDSPAVEQVEVYSEEDDEYSTDDDETESDD
SQ  ESDASDYTDIDTDTEAEDDESPE
//