ID  P14907;
PN  Nucleoporin NSP1;
GN  NSP1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
DR  UNIPROT: P14907;
DR  UNIPROT: D6VWE3;
DR  PDB: 1O6O;
DR  PDB: 7N85;
DR  PDB: 7N9F;
DR  PDB: 7WOO;
DR  PDB: 7WOT;
DR  Pfam: PF05064;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NSP1 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, pre-ribosome, signal recognition particle (SRP), and protein transport. {ECO:0000269|PubMed:10889207, ECO:0000269|PubMed:10952996, ECO:0000269|PubMed:11352936, ECO:0000269|PubMed:11387327, ECO:0000269|PubMed:11689687, ECO:0000269|PubMed:11739405, ECO:0000269|PubMed:12604785, ECO:0000269|PubMed:15039779, ECO:0000269|PubMed:9017593, ECO:0000269|PubMed:9461539, ECO:0000269|PubMed:9774653, ECO:0000269|PubMed:9843582, ECO:0000269|PubMed:9891088}.
DE  Reference Proteome: Yes;
DE  Interaction: P48837; IntAct: EBI-390867; Score: 0.81
DE  Interaction: P02829; IntAct: EBI-763009; Score: 0.37
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.32
DE  Interaction: P34077; IntAct: EBI-789044; Score: 0.35
DE  Interaction: P40368; IntAct: EBI-790236; Score: 0.87
DE  Interaction: Q02630; IntAct: EBI-795280; Score: 0.35
DE  Interaction: P40066; IntAct: EBI-797307; Score: 0.44
DE  Interaction: Q02199; IntAct: EBI-801342; Score: 0.68
DE  Interaction: P40477; IntAct: EBI-805203; Score: 0.59
DE  Interaction: P51998; IntAct: EBI-811019; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-811019; Score: 0.53
DE  Interaction: P22353; IntAct: EBI-811019; Score: 0.35
DE  Interaction: Q06678; IntAct: EBI-811019; Score: 0.35
DE  Interaction: P36516; IntAct: EBI-811019; Score: 0.35
DE  Interaction: P36525; IntAct: EBI-811019; Score: 0.35
DE  Interaction: P36523; IntAct: EBI-811019; Score: 0.35
DE  Interaction: Q04599; IntAct: EBI-811019; Score: 0.35
DE  Interaction: P36161; IntAct: EBI-7438937; Score: 0.44
DE  Interaction: P40005; IntAct: EBI-8464369; Score: 0.56
DE  Interaction: P48363; IntAct: EBI-8464653; Score: 0.56
DE  Interaction: Q14974; IntAct: EBI-1034546; Score: 0.62
DE  Interaction: Q04175; IntAct: EBI-1173446; Score: 0.40
DE  Interaction: Q06142; IntAct: EBI-1173482; Score: 0.72
DE  Interaction: P32499; IntAct: EBI-6322490; Score: 0.00
DE  Interaction: P29295; IntAct: EBI-2612057; Score: 0.35
DE  Interaction: P23291; IntAct: EBI-2614250; Score: 0.35
DE  Interaction: P24869; IntAct: EBI-2617071; Score: 0.35
DE  Interaction: P26448; IntAct: EBI-2882390; Score: 0.00
DE  Interaction: P22696; IntAct: EBI-2883245; Score: 0.00
DE  Interaction: Q02796; IntAct: EBI-2885546; Score: 0.00
DE  Interaction: P39723; IntAct: EBI-2887969; Score: 0.00
DE  Interaction: Q04477; IntAct: EBI-2887856; Score: 0.00
DE  Interaction: P48353; IntAct: EBI-3658592; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3673674; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3691838; Score: 0.35
DE  Interaction: P52553; IntAct: EBI-3739443; Score: 0.35
DE  Interaction: P53900; IntAct: EBI-3739619; Score: 0.35
DE  Interaction: P33416; IntAct: EBI-3745755; Score: 0.35
DE  Interaction: P15992; IntAct: EBI-3750055; Score: 0.35
DE  Interaction: P38915; IntAct: EBI-4375569; Score: 0.35
DE  Interaction: P50875; IntAct: EBI-4376349; Score: 0.35
DE  Interaction: Q03330; IntAct: EBI-4377624; Score: 0.35
DE  Interaction: Q02336; IntAct: EBI-4378994; Score: 0.35
DE  Interaction: P50102; IntAct: EBI-4379349; Score: 0.35
DE  Interaction: P36160; IntAct: EBI-7433031; Score: 0.35
DE  Interaction: Q8IYF3; IntAct: EBI-11523349; Score: 0.56
DE  Interaction: Q05166; IntAct: EBI-11888294; Score: 0.37
DE  Interaction: P61970; IntAct: EBI-15747989; Score: 0.44
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0034399;
GO  GO:0005643;
GO  GO:0044613;
GO  GO:0044615;
GO  GO:0060090;
GO  GO:0005543;
GO  GO:0017056;
GO  GO:0007049;
GO  GO:0097064;
GO  GO:0006607;
GO  GO:0006913;
GO  GO:0016973;
GO  GO:0006606;
GO  GO:0000055;
GO  GO:0000056;
GO  GO:0006405;
GO  GO:0006409;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MNFNTPQQNKTPFSFGTANNNSNTTNQNSSTGAGAFGTGQSTFGFNNSAPNNTNNANSSITPAFGSNNTGNTAFGNSNPT
SQ  SNVFGSNNSTTNTFGSNSAGTSLFGSSSAQQTKSNGTAGGNTFGSSSLFNNSTNSNTTKPAFGGLNFGGGNNTTPSSTGN
SQ  ANTSNNLFGATANANKPAFSFGATTNDDKKTEPDKPAFSFNSSVGNKTDAQAPTTGFSFGSQLGGNKTVNEAAKPSLSFG
SQ  SGSAGANPAGASQPEPTTNEPAKPALSFGTATSDNKTTNTTPSFSFGAKSDENKAGATSKPAFSFGAKPEEKKDDNSSKP
SQ  AFSFGAKSNEDKQDGTAKPAFSFGAKPAEKNNNETSKPAFSFGAKSDEKKDGDASKPAFSFGAKPDENKASATSKPAFSF
SQ  GAKPEEKKDDNSSKPAFSFGAKSNEDKQDGTAKPAFSFGAKPAEKNNNETSKPAFSFGAKSDEKKDGDASKPAFSFGAKS
SQ  DEKKDSDSSKPAFSFGTKSNEKKDSGSSKPAFSFGAKPDEKKNDEVSKPAFSFGAKANEKKESDESKSAFSFGSKPTGKE
SQ  EGDGAKAAISFGAKPEEQKSSDTSKPAFTFGAQKDNEKKTEESSTGKSTADVKSSDSLKLNSKPVELKPVSLDNKTLDDL
SQ  VTKWTNQLTESASHFEQYTKKINSWDQVLVKGGEQISQLYSDAVMAEHSQNKIDQSLQYIERQQDELENFLDNFETKTEA
SQ  LLSDVVSTSSGAAANNNDQKRQQAYKTAQTLDENLNSLSSNLSSLIVEINNVSNTFNKTTNIDINNEDENIQLIKILNSH
SQ  FDALRSLDDNSTSLEKQINSIKK
//