ID  P15389;
PN  Sodium channel protein type 5 subunit alpha;
GN  Scn5a;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000250|UniProtKB:Q14524}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q14524}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:15579534}. Note=RANGRF promotes trafficking to the cell membrane. {ECO:0000250|UniProtKB:Q14524}.
DR  UNIPROT: P15389;
DR  UNIPROT: Q925G6;
DR  PDB: 6UZ0;
DR  PDB: 6UZ3;
DR  PDB: 7FBS;
DR  PDB: 7K18;
DR  Pfam: PF00520;
DR  Pfam: PF06512;
DR  Pfam: PF11933;
DE  Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels. {ECO:0000250|UniProtKB:Q14524, ECO:0000250|UniProtKB:Q9JJV9}.
DE  Reference Proteome: Yes;
DE  Interaction: Q64273; IntAct: EBI-15981683; Score: 0.35
DE  Interaction: Q62696; IntAct: EBI-15981701; Score: 0.35
GO  GO:0005901;
GO  GO:0009986;
GO  GO:0005783;
GO  GO:0016021;
GO  GO:0014704;
GO  GO:0016328;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0042383;
GO  GO:0034706;
GO  GO:0030315;
GO  GO:0001518;
GO  GO:0030018;
GO  GO:0030506;
GO  GO:0005516;
GO  GO:0019899;
GO  GO:0017134;
GO  GO:0050998;
GO  GO:0019904;
GO  GO:0019901;
GO  GO:0097110;
GO  GO:0044325;
GO  GO:0031625;
GO  GO:0005244;
GO  GO:0005248;
GO  GO:0086060;
GO  GO:0086061;
GO  GO:0086006;
GO  GO:0086062;
GO  GO:0086063;
GO  GO:0086014;
GO  GO:0086016;
GO  GO:0086067;
GO  GO:0003360;
GO  GO:0086043;
GO  GO:0086002;
GO  GO:0060048;
GO  GO:0003231;
GO  GO:0071277;
GO  GO:0021549;
GO  GO:0051899;
GO  GO:0086010;
GO  GO:0098912;
GO  GO:0086045;
GO  GO:0086048;
GO  GO:0086012;
GO  GO:0086047;
GO  GO:0086046;
GO  GO:0019228;
GO  GO:0042475;
GO  GO:0045760;
GO  GO:0050679;
GO  GO:0010460;
GO  GO:0010765;
GO  GO:0060371;
GO  GO:0060372;
GO  GO:0086004;
GO  GO:0002027;
GO  GO:0086091;
GO  GO:1902305;
GO  GO:0060373;
GO  GO:0060307;
GO  GO:0014894;
GO  GO:0014070;
GO  GO:0086015;
GO  GO:0098719;
GO  GO:0035725;
GO  GO:0006814;
GO  GO:0021537;
GO  GO:0086005;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:D0E0C2};
SQ  MANLLLPRGTSSFRRFTRESLAAIEKRMAEKQARGGSATSQESREGLQEEEAPRPQLDLQASKKLPDLYGNPPRELIGEP
SQ  LEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKY
SQ  VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTI
SQ  VGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGLVWNSLDVYLNDPANYLLKNG
SQ  TTDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFL
SQ  GSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVTNHERKSKRR
SQ  KRLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHRT
SQ  SLLVPWPLRHPSAQGQPGPGASAPGYVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSYLLRPMVLDRPPDTTTPSEEPGG
SQ  PQMLTPQAPCADGFEEPGARQRALSAVSVLTSALEELEESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFA
SQ  DLTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLS
SQ  RMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLP
SQ  RWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMN
SQ  NLQLALARIQRGLRFVKRTTWDFCCGILRRRPKKPAALATHSQLPSCITAPRSPPPPEVEKVPPARKETRFEEDKRPGQG
SQ  TPGDSEPVCVPIAVAESDTEDQEEDEENSLGTEEESSKQESQVVSGGHEPYQEPRAWSQVSETTSSEAGASTSQADWQQE
SQ  QKTEPQAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTTQSPGKVWWRLRKTC
SQ  YRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI
SQ  VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG
SQ  KFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP
SQ  QWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQ
SQ  GFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKMAALRHYYFTNSWNIFDFVV
SQ  VILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMAN
SQ  FAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIII
SQ  SFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEPLRIAKPNQISLINM
SQ  DLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSATVIQRAFRRHLLQ
SQ  RSVKHASFLFRQQAGGSGLSDEDAPEREGLIAYMMNGNFSRRSAPLSSSSISSTSFPPSYDSVTRATSDNLPVRASDYSR
SQ  SEDLADFPPSPDRDRESIV
//