ID  P15565;
PN  tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial;
GN  TRM1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: [Isoform 1]: Mitochondrion. [Isoform 2]: Mitochondrion. Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Predominantly targeted to the nucleus.
DR  UNIPROT: P15565;
DR  UNIPROT: D6VSA6;
DR  UNIPROT: Q9URQ7;
DR  UNIPROT: Q9URQ8;
DR  Pfam: PF02005;
DR  PROSITE: PS51626;
DE  Function: Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Required for the modification of both mitochondrial and cytoplasmic tRNAs.
DE  Reference Proteome: Yes;
DE  Interaction: P15565; IntAct: EBI-7115479; Score: 0.40
DE  Interaction: P40032; IntAct: EBI-7094031; Score: 0.40
DE  Interaction: Q06704; IntAct: EBI-7094258; Score: 0.40
DE  Interaction: P38719; IntAct: EBI-8223418; Score: 0.22
DE  Interaction: P39101; IntAct: EBI-3654346; Score: 0.35
DE  Interaction: P32527; IntAct: EBI-3656468; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3678874; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3697299; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3730778; Score: 0.35
DE  Interaction: P33416; IntAct: EBI-3747899; Score: 0.35
DE  Interaction: P38788; IntAct: EBI-3792076; Score: 0.35
DE  Interaction: P35177; IntAct: EBI-4374839; Score: 0.35
DE  Interaction: P38915; IntAct: EBI-4375569; Score: 0.35
DE  Interaction: P50875; IntAct: EBI-4376349; Score: 0.35
DE  Interaction: Q12060; IntAct: EBI-4376999; Score: 0.35
DE  Interaction: Q03330; IntAct: EBI-4377624; Score: 0.35
DE  Interaction: Q02336; IntAct: EBI-4378314; Score: 0.35
DE  Interaction: P50102; IntAct: EBI-4379769; Score: 0.35
DE  Interaction: Q05027; IntAct: EBI-4382094; Score: 0.35
DE  Interaction: P25555; IntAct: EBI-16294689; Score: 0.00
DE  Interaction: P39996; IntAct: EBI-16294709; Score: 0.00
DE  Interaction: P40582; IntAct: EBI-16294729; Score: 0.00
DE  Interaction: Q07980; IntAct: EBI-16294749; Score: 0.00
GO  GO:0005739;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0005634;
GO  GO:0004809;
GO  GO:0000049;
GO  GO:0030488;
GO  GO:0002940;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MEGFFRIPLKRANLHGMLKAAISKIKANFTAYGAPRINIEDFNIVKEGKAEILFPKKETVFYNPIQQFNRDLSVTCIKAW
SQ  DNLYGEECGQKRNNKKSKKKRCAETNDDSSKRQKMGNGSPKEAVGNSNRNEPYINILEALSATGLRAIRYAHEIPHVREV
SQ  IANDLLPEAVESIKRNVEYNSVENIVKPNLDDANVLMYRNKATNNKFHVIDLDPYGTVTPFVDAAIQSIEEGGLMLVTCT
SQ  DLSVLAGNGYPEKCFALYGGANMVSHESTHESALRLVLNLLKQTAAKYKKTVEPLLSLSIDFYVRVFVKVKTSPIEVKNV
SQ  MSSTMTTYHCSRCGSYHNQPLGRISQREGRNNKTFTKYSVAQGPPVDTKCKFCEGTYHLAGPMYAGPLHNKEFIEEVLRI
SQ  NKEEHRDQDDTYGTRKRIEGMLSLAKNELSDSPFYFSPNHIASVIKLQVPPLKKVVAGLGSLGFECSLTHAQPSSLKTNA
SQ  PWDAIWYVMQKCDDEKKDLSKMNPNTTGYKILSAMPGWLSGTVKSEYDSKLSFAPNEQSGNIEKLRKLKIVRYQENPTKN
SQ  WGPKARPNTS
//