ID  P18410;
PN  Sporulation-specific protein SPO7;
GN  SPO7;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9822591}; Multi-pass membrane protein {ECO:0000269|PubMed:9822591}. Nucleus membrane {ECO:0000269|PubMed:9822591}; Multi-pass membrane protein {ECO:0000269|PubMed:9822591}.
DR  UNIPROT: P18410;
DR  UNIPROT: D6VPK9;
DR  Pfam: PF03907;
DE  Function: Regulatory component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates the phosphatidic acid phosphohydrolase PAH1 (PubMed:15889145). Essential for the formation of a spherical nucleus and meiotic division (PubMed:9822591). The NEM1-SPOo7 protein phosphatase is required for efficient mitophagy under prolonged respiration, as well as for reticulophagy and pexophagy (PubMed:29305265). {ECO:0000269|PubMed:15889145, ECO:0000269|PubMed:29305265, ECO:0000269|PubMed:9822591}.
DE  Reference Proteome: Yes;
DE  Interaction: P10664; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P16140; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P32591; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P05753; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P02407; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P05737; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P05739; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P49626; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P04147; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P38757; IntAct: EBI-787710; Score: 0.56
DE  Interaction: P12945; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P32501; IntAct: EBI-787710; Score: 0.35
DE  Interaction: P38631; IntAct: EBI-787710; Score: 0.35
DE  Interaction: Q02772; IntAct: EBI-6317771; Score: 0.00
DE  Interaction: P04821; IntAct: EBI-7299668; Score: 0.44
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0071595;
GO  GO:0031965;
GO  GO:0019888;
GO  GO:0006629;
GO  GO:0071072;
GO  GO:0006998;
GO  GO:1903740;
GO  GO:0071071;
GO  GO:0061709;
GO  GO:0030435;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MEPESIGDVGNHAQDDSASIVSGPRRRSTSKTSSAKNIRNSSNISPASMIFRNLLILEDDLRRQAHEQKILKWQFTLFLA
SQ  SMAGVGAFTFYELYFTSDYVKGLHRVILQFTLSFISITVVLFHISGQYRRTIVIPRRFFTSTNKGIRQFNVKLVKVQSTW
SQ  DEKYTDSVRFVSRTIAYCNIYCLKKFLWLKDDNAIVKFWKSVTIQSQPRIGAVDVKLVLNPRAFSAEIREGWEIYRDEFW
SQ  AREGARRRKQAHELRPKSE
//