ID  P20292;
PN  Arachidonate 5-lipoxygenase-activating protein;
GN  ALOX5AP;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
DR  UNIPROT: P20292;
DR  UNIPROT: Q5VV04;
DR  PDB: 2Q7M;
DR  PDB: 2Q7R;
DR  PDB: 6VGC;
DR  PDB: 6VGI;
DR  Pfam: PF01124;
DR  PROSITE: PS01297;
DR  OMIM: 601367;
DR  OMIM: 603700;
DR  DisGeNET: 241;
DE  Function: Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO:0000269|PubMed:2300173, ECO:0000269|PubMed:8440384}.
DE  Disease: Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. {ECO:0000269|PubMed:14770184, ECO:0000269|PubMed:17304054}.
DE  Reference Proteome: Yes;
DE  Interaction: A0PK00; IntAct: EBI-24765164; Score: 0.56
DE  Interaction: O00299; IntAct: EBI-3904626; Score: 0.37
DE  Interaction: Q9H115; IntAct: EBI-24738406; Score: 0.56
DE  Interaction: Q96FB2; IntAct: EBI-24768960; Score: 0.56
DE  Interaction: O15529; IntAct: EBI-24778364; Score: 0.56
DE  Interaction: P35372; IntAct: EBI-24571720; Score: 0.56
DE  Interaction: Q13520; IntAct: EBI-24799898; Score: 0.56
DE  Interaction: O15552; IntAct: EBI-24808129; Score: 0.56
DE  Interaction: Q70Z53; IntAct: EBI-21893005; Score: 0.40
DE  Interaction: P20292; IntAct: EBI-26452342; Score: 0.40
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0004051;
GO  GO:0050544;
GO  GO:0008047;
GO  GO:0019899;
GO  GO:0004602;
GO  GO:0004364;
GO  GO:0042802;
GO  GO:0004464;
GO  GO:0047485;
GO  GO:0044877;
GO  GO:0071277;
GO  GO:0019370;
GO  GO:0002540;
GO  GO:0019372;
GO  GO:0002675;
GO  GO:0070207;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis;
SQ  MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQ
SQ  VPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLI
SQ  P
//