ID  P20449;
PN  ATP-dependent RNA helicase DBP5;
GN  DBP5;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils. Accumulates in the nucleus rapidly and reversibly in response to ethanol stress.
DR  UNIPROT: P20449;
DR  UNIPROT: D6W2B2;
DR  PDB: 2KBE;
DR  PDB: 2KBF;
DR  PDB: 3GFP;
DR  PDB: 3PEU;
DR  PDB: 3PEV;
DR  PDB: 3PEW;
DR  PDB: 3PEY;
DR  PDB: 3RRM;
DR  PDB: 3RRN;
DR  PDB: 5ELX;
DR  Pfam: PF00270;
DR  Pfam: PF00271;
DR  PROSITE: PS00039;
DR  PROSITE: PS51192;
DR  PROSITE: PS51194;
DR  PROSITE: PS51195;
DE  Function: ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. Contributes to the blocking of bulk poly(A)+ mRNA export in ethanol-stressed cells. May also be involved in early transcription. {ECO:0000269|PubMed:10428971, ECO:0000269|PubMed:10523319, ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:11350039, ECO:0000269|PubMed:12192043, ECO:0000269|PubMed:12686617, ECO:0000269|PubMed:15280434, ECO:0000269|PubMed:15574330, ECO:0000269|PubMed:15619606, ECO:0000269|PubMed:9564047, ECO:0000269|PubMed:9564048}.
DE  Reference Proteome: Yes;
DE  Interaction: Q02159; IntAct: EBI-860380; Score: 0.00
DE  Interaction: P40477; IntAct: EBI-7266119; Score: 0.66
DE  Interaction: Q04839; IntAct: EBI-7998113; Score: 0.66
DE  Interaction: P50111; IntAct: EBI-2132816; Score: 0.51
DE  Interaction: P32491; IntAct: EBI-2617619; Score: 0.35
DE  Interaction: P40484; IntAct: EBI-2617649; Score: 0.35
DE  Interaction: Q12529; IntAct: EBI-2887496; Score: 0.00
DE  Interaction: P40564; IntAct: EBI-3656740; Score: 0.35
DE  Interaction: P33416; IntAct: EBI-3744163; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3778915; Score: 0.35
DE  Interaction: P39987; IntAct: EBI-3787386; Score: 0.35
DE  Interaction: P04147; IntAct: EBI-7082780; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-15806702; Score: 0.76
GO  GO:0005934;
GO  GO:0005737;
GO  GO:0010494;
GO  GO:0031965;
GO  GO:0044614;
GO  GO:0005634;
GO  GO:0005844;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0008186;
GO  GO:0003723;
GO  GO:0003724;
GO  GO:0006406;
GO  GO:0016973;
GO  GO:0015031;
GO  GO:0006415;
GO  GO:0006409;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MSDTKRDPADLLASLKIDNEKEDTSEVSTKETVKSQPEKTADSIKPAEKLVPKVEEKKTKQEDSNLISSEYEVKVKLADI
SQ  QADPNSPLYSAKSFDELGLAPELLKGIYAMKFQKPSKIQERALPLLLHNPPRNMIAQSQSGTGKTAAFSLTMLTRVNPED
SQ  ASPQAICLAPSRELARQTLEVVQEMGKFTKITSQLIVPDSFEKNKQINAQVIVGTPGTVLDLMRRKLMQLQKIKIFVLDE
SQ  ADNMLDQQGLGDQCIRVKRFLPKDTQLVLFSATFADAVRQYAKKIVPNANTLELQTNEVNVDAIKQLYMDCKNEADKFDV
SQ  LTELYGLMTIGSSIIFVATKKTANVLYGKLKSEGHEVSILHGDLQTQERDRLIDDFREGRSKVLITTNVLARGIDIPTVS
SQ  MVVNYDLPTLANGQADPATYIHRIGRTGRFGRKGVAISFVHDKNSFNILSAIQKYFGDIEMTRVPTDDWDEVEKIVKKVL
SQ  KD
//