ID  P20592;
PN  Interferon-induced GTP-binding protein Mx2;
GN  MX2;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:15184662}. Nucleus {ECO:0000269|PubMed:15184662}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15184662}. Note=Localization to nuclear pores requires GTP-binding.
DR  UNIPROT: P20592;
DR  UNIPROT: B7Z5D3;
DR  UNIPROT: D3DSI7;
DR  PDB: 4WHJ;
DR  PDB: 4X0R;
DR  PDB: 5UOT;
DR  Pfam: PF01031;
DR  Pfam: PF00350;
DR  Pfam: PF02212;
DR  PROSITE: PS00410;
DR  PROSITE: PS51718;
DR  PROSITE: PS51388;
DR  OMIM: 147890;
DR  DisGeNET: 4600;
DE  Function: Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. {ECO:0000269|PubMed:15184662, ECO:0000269|PubMed:24048477, ECO:0000269|PubMed:24055605, ECO:0000269|PubMed:24121441}.
DE  Reference Proteome: Yes;
DE  Interaction: A2ABF9; IntAct: EBI-10200624; Score: 0.56
DE  Interaction: O75928; IntAct: EBI-10200636; Score: 0.56
DE  Interaction: Q8WXE1; IntAct: EBI-10200646; Score: 0.56
DE  Interaction: Q96KQ7; IntAct: EBI-24422219; Score: 0.56
DE  Interaction: P16749; IntAct: EBI-15832895; Score: 0.41
DE  Interaction: P35226; IntAct: EBI-27109494; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0016020;
GO  GO:0005874;
GO  GO:0005643;
GO  GO:0005634;
GO  GO:0005525;
GO  GO:0003924;
GO  GO:0008017;
GO  GO:0006952;
GO  GO:0051607;
GO  GO:0045087;
GO  GO:0051028;
GO  GO:0015031;
GO  GO:0051726;
GO  GO:0046822;
GO  GO:0035455;
GO  GO:0009615;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLAKDFNFLTLNNQPPPGNRSQP
SQ  RAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLK
SQ  KQPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRD
SQ  IGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKK
SQ  GYMIVKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKA
SQ  TEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEV
SQ  EKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKH
SQ  TAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPLGTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKR
SQ  LANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH
//