ID  P21279;
PN  Guanine nucleotide-binding protein G(q) subunit alpha;
GN  Gnaq;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cell membrane {ECO:0000269|PubMed:19001095}; Lipid-anchor {ECO:0000269|PubMed:19001095}. Golgi apparatus {ECO:0000250|UniProtKB:P50148}. Nucleus {ECO:0000269|PubMed:18802028}. Nucleus membrane {ECO:0000269|PubMed:18802028}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000269|PubMed:18802028}.
DR  UNIPROT: P21279;
DR  UNIPROT: Q6PFF5;
DR  PDB: 2BCJ;
DR  PDB: 2RGN;
DR  PDB: 3AH8;
DR  PDB: 4EKC;
DR  PDB: 4EKD;
DR  PDB: 4GNK;
DR  PDB: 4QJ3;
DR  PDB: 4QJ4;
DR  PDB: 4QJ5;
DR  PDB: 5DO9;
DR  PDB: 7SQ2;
DR  Pfam: PF00503;
DR  PROSITE: PS51882;
DE  Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:9687499). Required for platelet activation (PubMed:9296496). Regulates B-cell selection and survival and is required to prevent B- cell-dependent autoimmunity (PubMed:20624888). Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (PubMed:17938235). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNA11, required for heart development (PubMed:9687499). {ECO:0000250|UniProtKB:P50148, ECO:0000269|PubMed:17938235, ECO:0000269|PubMed:20624888, ECO:0000269|PubMed:9296496, ECO:0000269|PubMed:9687499}.
DE  Reference Proteome: Yes;
DE  Interaction: O08915; IntAct: EBI-6979702; Score: 0.52
DE  Interaction: P11416; IntAct: EBI-6259164; Score: 0.27
DE  Interaction: P08587; IntAct: EBI-8071193; Score: 0.44
DE  Interaction: O54912; IntAct: EBI-15571558; Score: 0.40
DE  Interaction: Q9ES08; IntAct: EBI-15571606; Score: 0.40
DE  Interaction: Q01970; IntAct: EBI-15939025; Score: 0.75
DE  Interaction: Q8R4D5; IntAct: EBI-15993510; Score: 0.40
DE  Interaction: P41220; IntAct: EBI-16037484; Score: 0.62
DE  Interaction: Q3UHD9; IntAct: EBI-16736255; Score: 0.35
DE  Interaction: P62871; IntAct: EBI-21282654; Score: 0.27
DE  Interaction: P63278; IntAct: EBI-22091990; Score: 0.35
DE  Interaction: Q4ACU6; IntAct: EBI-26960892; Score: 0.35
DE  Interaction: P16056; IntAct: EBI-27112678; Score: 0.35
GO  GO:0005901;
GO  GO:0044297;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0005794;
GO  GO:0005834;
GO  GO:0016020;
GO  GO:0031965;
GO  GO:0005886;
GO  GO:0045202;
GO  GO:0047391;
GO  GO:0001664;
GO  GO:0031683;
GO  GO:0005525;
GO  GO:0005096;
GO  GO:0003924;
GO  GO:0046872;
GO  GO:0044877;
GO  GO:0001508;
GO  GO:0007202;
GO  GO:0007189;
GO  GO:0007188;
GO  GO:1904888;
GO  GO:0048066;
GO  GO:0042733;
GO  GO:0086100;
GO  GO:0021884;
GO  GO:0007186;
GO  GO:0007215;
GO  GO:0007507;
GO  GO:0042711;
GO  GO:0010259;
GO  GO:0043066;
GO  GO:0043267;
GO  GO:0006469;
GO  GO:0016322;
GO  GO:0060158;
GO  GO:0007200;
GO  GO:0048661;
GO  GO:0009791;
GO  GO:0050821;
GO  GO:0008217;
GO  GO:0060828;
GO  GO:0045634;
GO  GO:0010543;
GO  GO:0001501;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:8227063};
SQ  MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVY
SQ  QNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYY
SQ  LNDLDRVADPSYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
SQ  ESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDS
SQ  DKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
//