ID  P22059;
PN  Oxysterol-binding protein 1;
GN  OSBP;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, cytosol {ECO:0000269|PubMed:24209621, ECO:0000269|PubMed:29514919}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24209621}. Golgi apparatus membrane; Peripheral membrane protein {ECO:0000269|PubMed:24209621}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000269|PubMed:24209621}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29514919}. Note=Predominantly cytosolic. {ECO:0000269|PubMed:24209621}.
DR  UNIPROT: P22059;
DR  UNIPROT: Q6P524;
DR  PDB: 2RR3;
DR  Pfam: PF01237;
DR  Pfam: PF00169;
DR  PROSITE: PS01013;
DR  PROSITE: PS50003;
DR  OMIM: 167040;
DR  DisGeNET: 5007;
DE  Function: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25- hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}.
DE  Reference Proteome: Yes;
DE  Interaction: P08047; IntAct: EBI-2681899; Score: 0.00
DE  Interaction: P68400; IntAct: EBI-5321687; Score: 0.44
DE  Interaction: O75344; IntAct: EBI-9364555; Score: 0.62
DE  Interaction: A0A0H3NDL6; IntAct: EBI-10690222; Score: 0.52
DE  Interaction: Q8ZNG2; IntAct: EBI-10710869; Score: 0.52
DE  Interaction: Q9P0L0; IntAct: EBI-11120309; Score: 0.74
DE  Interaction: Q86X19; IntAct: EBI-11372615; Score: 0.27
DE  Interaction: Q9P0N5; IntAct: EBI-11378021; Score: 0.27
DE  Interaction: Q86UE6; IntAct: EBI-21507777; Score: 0.35
DE  Interaction: Q6UX41; IntAct: EBI-21529766; Score: 0.35
DE  Interaction: Q7KYR7; IntAct: EBI-21541130; Score: 0.35
DE  Interaction: O95292; IntAct: EBI-21550215; Score: 0.35
DE  Interaction: Q8WWF5; IntAct: EBI-21589535; Score: 0.35
DE  Interaction: Q9NRJ7; IntAct: EBI-21590428; Score: 0.35
DE  Interaction: P33151; IntAct: EBI-21650356; Score: 0.35
DE  Interaction: Q9Y5G8; IntAct: EBI-21697051; Score: 0.35
DE  Interaction: P05120; IntAct: EBI-21713063; Score: 0.35
DE  Interaction: Q96FV0; IntAct: EBI-21840089; Score: 0.35
DE  Interaction: P61769; IntAct: EBI-20911136; Score: 0.40
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: Q92685; IntAct: EBI-25468424; Score: 0.51
DE  Interaction: Q8NHP6; IntAct: EBI-25617363; Score: 0.40
DE  Interaction: A0A0F6B423; IntAct: EBI-27033608; Score: 0.46
DE  Interaction: A0A0F6B1Q8; IntAct: EBI-27036840; Score: 0.46
DE  Interaction: Q8N488; IntAct: EBI-27110926; Score: 0.35
DE  Interaction: Q16288; IntAct: EBI-32724526; Score: 0.27
GO  GO:0030054;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005789;
GO  GO:0005794;
GO  GO:0000139;
GO  GO:0043231;
GO  GO:0016020;
GO  GO:0005730;
GO  GO:0005654;
GO  GO:0097038;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005802;
GO  GO:0008142;
GO  GO:0070273;
GO  GO:0019904;
GO  GO:0032934;
GO  GO:0120015;
GO  GO:0015248;
GO  GO:0006699;
GO  GO:0035627;
GO  GO:0032367;
GO  GO:0015914;
GO  GO:0035774;
GO  GO:1904411;
GO  GO:0042531;
GO  GO:0006686;
GO  GO:0015918;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:24209621};
SQ  MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGPGAGGVAAAGPAPAPPTGGSG
SQ  GSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYH
SQ  LKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLS
SQ  ELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLER
SQ  AFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEE
SQ  TKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFT
SQ  VSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLG
SQ  TIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHF
SQ  ALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPD
SQ  QRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDW
SQ  SSCPDIF
//