ID  P22892;
PN  AP-1 complex subunit gamma-1;
GN  Ap1g1;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Golgi apparatus {ECO:0000250|UniProtKB:O43747}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O43747}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43747}; Cytoplasmic side {ECO:0000250|UniProtKB:O43747}. Cytoplasm {ECO:0000250|UniProtKB:O43747}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O43747}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:O43747}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:O43747}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (By similarity). Co-localizes with AFTPH/aftiphilin in the cytoplasm (By similarity). {ECO:0000250|UniProtKB:O43747}.
DR  UNIPROT: P22892;
DR  PDB: 1GYU;
DR  PDB: 1GYV;
DR  PDB: 1GYW;
DR  PDB: 1W63;
DR  PDB: 2A7B;
DR  PDB: 3ZY7;
DR  PDB: 4HMY;
DR  PDB: 4P6Z;
DR  PDB: 6CM9;
DR  PDB: 6CRI;
DR  PDB: 6D83;
DR  PDB: 6D84;
DR  PDB: 6DFF;
DR  Pfam: PF01602;
DR  Pfam: PF02883;
DR  PROSITE: PS50180;
DE  Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity). {ECO:0000250|UniProtKB:O43747}.
DE  Reference Proteome: Yes;
DE  Interaction: Q07113; IntAct: EBI-7855082; Score: 0.44
DE  Interaction: P52303; IntAct: EBI-1040301; Score: 0.40
DE  Interaction: Q14677; IntAct: EBI-7071326; Score: 0.54
DE  Interaction: Q9JIF3; IntAct: EBI-7048197; Score: 0.40
DE  Interaction: P46096; IntAct: EBI-7837071; Score: 0.27
DE  Interaction: Q62277; IntAct: EBI-7837084; Score: 0.27
DE  Interaction: Q10567; IntAct: EBI-6863559; Score: 0.74
DE  Interaction: P84077; IntAct: EBI-6864775; Score: 0.35
DE  Interaction: Q96PC3; IntAct: EBI-6864775; Score: 0.35
DE  Interaction: P35585; IntAct: EBI-6864775; Score: 0.66
DE  Interaction: O75379; IntAct: EBI-6868249; Score: 0.35
DE  Interaction: O54774; IntAct: EBI-9103779; Score: 0.35
DE  Interaction: P18242; IntAct: EBI-9103779; Score: 0.35
DE  Interaction: Q68FD5; IntAct: EBI-9103779; Score: 0.35
DE  Interaction: P11438; IntAct: EBI-9103779; Score: 0.35
DE  Interaction: Q8BKC8; IntAct: EBI-9103779; Score: 0.35
DE  Interaction: Q9CQD1; IntAct: EBI-9103779; Score: 0.35
DE  Interaction: O88384; IntAct: EBI-9103735; Score: 0.35
DE  Interaction: P61966; IntAct: EBI-10960176; Score: 0.40
GO  GO:0030121;
GO  GO:0030136;
GO  GO:0005829;
GO  GO:0005769;
GO  GO:0005794;
GO  GO:0043231;
GO  GO:0005765;
GO  GO:0048471;
GO  GO:0055037;
GO  GO:0005802;
GO  GO:0032588;
GO  GO:0140312;
GO  GO:0035615;
GO  GO:0030742;
GO  GO:0019894;
GO  GO:0031267;
GO  GO:0110010;
GO  GO:0035646;
GO  GO:0090160;
GO  GO:0006896;
GO  GO:0006886;
GO  GO:1903232;
GO  GO:0060155;
GO  GO:0043323;
GO  GO:0045954;
GO  GO:0006898;
GO  GO:0016192;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:O43747};
SQ  MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKFT
SQ  DKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALC
SQ  AVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGI
SQ  SDPFLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNN
SQ  DKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKADC
SQ  ASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCI
SQ  GEYGDLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGSSIDVELQ
SQ  QRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPSEIVQTNGETEPAPLETKPPPSGPQPTSQANDLLDLLGGNDITPV
SQ  IPTAPTSKPASAGGELLDLLGDITLTGAPAAAPTPASVPQISQPPFLLDGLSSQPLFNDIAPGIPSITAYSKNGLKIEFT
SQ  FERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSVVPAFNTGTITQVIKVLNPQKQQLRMRIKLTY
SQ  NHKGSAMQDLAEVNNFPPQSWQ
//