ID  P23456;
PN  cap-snatching endonuclease;
GN  L;
OS  11602;
SL  Nucleus Position: SL-0382;
SL  Comments: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q9YQR5}.
DR  UNIPROT: P23456;
DR  PDB: 5IZE;
DR  Pfam: PF04196;
DR  Pfam: PF12426;
DR  PROSITE: PS50525;
DE  Function: RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate (By similarity). During transcription, synthesizes subgenomic RNAs and assures their capping by a cap- snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs (PubMed:27304209). These short capped RNAs are then used as primers for viral transcription. Cleaves ssRNA substrates but not DNA (By similarity). Seems to downregulate the expression of its own and heterologous mRNAs through its endonuclease activity (By similarity). {ECO:0000250|UniProtKB:Q9E005, ECO:0000269|PubMed:27304209}.
DE  Reference Proteome: Yes;
GO  GO:0044220;
GO  GO:0004519;
GO  GO:0046872;
GO  GO:0000166;
GO  GO:0003968;
GO  GO:0075526;
GO  GO:0006351;
GO  GO:0039689;
GO  GO:0039696;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDKYREIHNKLKEFSPGTLTAVECIDYLDRLYAVRHDIVDQMIKHDWSDNKDSEEAIGKVLLFAGVPSNIITALEKKIIP
SQ  NHPTGKSLKAFFKMTPDNYKISGTTIEFVEVTVTADVDKGIREKKLKYEAGLTYIEQELHKFFLKGEIPQPYKITFNVVA
SQ  VRTDGSNITTQWPSRRNDGVVQYMRLVQAEISYVREHLIKTEERAALEAMFNLKFNISTHKSQPYYIPDYKGMEPIGANI
SQ  EDLVDYSKDWLSRARNFSFFEVKGTAVFECFNSNEANHCQRYPMSRKPRNFLLIQCSLITSYKPATTLSDQIDSRRACSY
SQ  ILNLIPDTPASYLIHDMAYRYINLTREDMINYYAPRIQFKQTQNVREPGTFKLTSSMLRAESKAMLDLLNNHKSGEKHGA
SQ  QIESLNIASHIVQSESVSLITKILSDLELNITEPSTQEYSTTKHTYVDTVLDKFFQNETQKYLIDVLKKTTAWHIGHLIR
SQ  DITESLIAHSGLKRSKYWSLHSYNNGNVILFILPSKSLEVAGSFIRFITVFRIGPGLVDKDNLDTILIDGDSQWGVSKVM
SQ  SIDLNRLLALNIAFEKALIATATWFQYYTEDQGQFPLQYAIRSVFANHFLLAICQKMKLCAIFDNLRYLIPAVTSLYSGF
SQ  PSLIEKLFERPFKSSLEVYIYYNIKSLLVALAQNNKARFYSKVKLLGLTVDQSTVGASGVYPSFMSRIVYKHYRSLISEV
SQ  TTCFFLFEKGLHGNMNEEAKIHLETVEWALKFREKEEKYGESLVENGYMMWELRANAELAEQQLYCQDAIELAAIELNKV
SQ  LATKSSVVANSILSKNWEEPYFSQTRNISLKGMSGQVQEDGHLSSSVTIIEAIRYLSNSRHNPSLLKLYEETREQKAMAR
SQ  IVRKYQRTEADRGFFITTLPTRCRLEIIEDYYDAIAKNISEEYISYGGEKKILAIQGALEKALRWASGESFIELSNHKFI
SQ  RMKRKLMYVSADATKWSPGDNSAKFRRFTSMLHNGLPNNKLKNCVIDALKQVYKTDFFMSRKLRNYIDSMESLDPHIKQF
SQ  LDFFPDGHHGEVKGNWLQGNLNKCSSLFGVAMSLLFKQVWTNLFPELDCFFEFAHHSDDALFIYGYLEPVDDGTDWFLFV
SQ  SQQIQAGHLHWFSVNTEMWKSMFNLHEHILLLGSIKISPKKTTVSPTNAEFLSTFFEGCAVSIPFVKILLGSLSDLPGLG
SQ  YFDDLAAAQSRCVKALDLGASPQVAQLAVALCTSKVERLYGTAPGMVNHPAAYLQVKHTDTPIPLGGNGAMSIMELATAG
SQ  IGMSDKNLLKRALLGYSHKRQKSMLYILGLFKFLMKLSDETFQHERLGQFSFIGKVQWKIFTPKSEFEFADMYTSKFLEL
SQ  WSSQHVTYDYIIPKGRDNLLIYLVRKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCRLDGEWVTFREVLAAANSFAENY
SQ  SATSQDMDLFQTLTSCTFSKEYAWKDFLNGIHCDVIPTKQVQRAKVARTFTVREKDQIIQNSIPAVIGYKFAVTVEEMSD
SQ  VLDTAKFPDSLSVDLKTMKDGVYRELGLDISLPDVMKRIAPMLYKSSKSRVVIVQGNVEGTAEAICRYWLKSMSLVKTIR
SQ  VKPHKEVLQAVSIFNRKEDIGQQKDLAALKLCIEVWRWCKANSAPYRDWFQALWFEDKTFSEWLDRFCRVGVPPIDPEIQ
SQ  CAALMIADIKGDYSVLQLQANRRAYSGKQYDAYCVQTYNEVTKLYEGDLRVTFNFGLDCARLEIFWDKKAYILETSITQK
SQ  HVLKIMMDEVSKELIKCGMRFNTEQVQGVRHMVLFKTESGFEWGKPNIPCIVYKNCVLRTSLRTTQAINHKFMITIKDDG
SQ  LRAIAQHDEDSPRFLLAHAFHTIRDIRYQAVDAVSNVWFIHKGVKLYLNPIISSGLLENFMKNLPAAIPPAAYSLIMNRA
SQ  KISVDLFMFNDLLKLINPRNTLDLSGLETTGDEFSTVSSMSSRLWSEEMSLVDDDEELDDEFTIDLQDVDFENIDIEADI
SQ  EHFLQDESSYTGDLLISTEETESKKMRGIVKILEPVRLIKSWVSRGLSIEKVYSPVNIILMSRYISKTFNLSTKQVSLLD
SQ  PYDLTELESIVRGWGECVIDQFESLDREAQNMVVNKGICPEDVIPDSLFSFRHTMVLLRRLFPQDSISSFY
//