ID  P26572;
PN  Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase;
GN  MGAT1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Golgi apparatus membrane {ECO:0000269|PubMed:20378551}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:30983867}. Note=Co-localizes with BRI3 isoform 1 at the perinuclear region. {ECO:0000269|PubMed:30983867}.
DR  UNIPROT: P26572;
DR  UNIPROT: A8K404;
DR  UNIPROT: B3KRU8;
DR  UNIPROT: D3DWR1;
DR  UNIPROT: Q6IBE3;
DR  Pfam: PF03071;
DR  OMIM: 160995;
DR  DisGeNET: 4245;
DE  Function: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. {ECO:0000269|PubMed:1702225}.
DE  Reference Proteome: Yes;
DE  Interaction: O95415; IntAct: EBI-25504004; Score: 0.54
DE  Interaction: O15198; IntAct: EBI-7263379; Score: 0.37
DE  Interaction: Q16659; IntAct: EBI-7211987; Score: 0.37
DE  Interaction: P08563; IntAct: EBI-11478323; Score: 0.40
DE  Interaction: Q9Z1B5; IntAct: EBI-10996176; Score: 0.35
DE  Interaction: Q8R034; IntAct: EBI-11003686; Score: 0.35
DE  Interaction: Q91ZJ0; IntAct: EBI-11131714; Score: 0.35
DE  Interaction: Q8IUW5; IntAct: EBI-21555862; Score: 0.35
DE  Interaction: Q9BRR6; IntAct: EBI-21694151; Score: 0.35
DE  Interaction: Q96GX1; IntAct: EBI-21777303; Score: 0.35
DE  Interaction: Q9BYC5; IntAct: EBI-21833842; Score: 0.35
DE  Interaction: P03372; IntAct: EBI-21302175; Score: 0.35
DE  Interaction: P0DTC3; IntAct: EBI-26495719; Score: 0.35
DE  Interaction: Q8N488; IntAct: EBI-27110926; Score: 0.35
GO  GO:0033116;
GO  GO:0070062;
GO  GO:1903561;
GO  GO:0005794;
GO  GO:0000139;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0048471;
GO  GO:0008375;
GO  GO:0003827;
GO  GO:0030145;
GO  GO:0001701;
GO  GO:0006486;
GO  GO:0006487;
GO  GO:0018279;
GO  GO:0006049;
GO  GO:0019082;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALS
SQ  SQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVT
SQ  HIRQPDLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSA
SQ  WNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQGRACIRPEISRTMTFGRKGVS
SQ  HGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKA
SQ  LGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPLTWEGYDPSWN
//