ID  P27176;
PN  cap-snatching endonuclease;
GN  L;
OS  1337063;
SL  Nucleus Position: SL-0382;
SL  Comments: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q9YQR5}.
DR  UNIPROT: P27176;
DR  Pfam: PF04196;
DR  Pfam: PF12426;
DR  PROSITE: PS50525;
DE  Function: RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate (By similarity). During transcription, synthesizes subgenomic RNAs and assures their capping by a cap- snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. Cleaves ssRNA substrates but not DNA (By similarity). Seems to downregulate the expression of its own and heterologous mRNAs through its endonuclease activity (By similarity). {ECO:0000250|UniProtKB:Q9E005}.
DE  Reference Proteome: No;
GO  GO:0044220;
GO  GO:0004519;
GO  GO:0046872;
GO  GO:0000166;
GO  GO:0003968;
GO  GO:0075526;
GO  GO:0006351;
GO  GO:0039689;
GO  GO:0039696;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEKYREIHERVKEAVPGETSAVECLDLLDRLYAVRHDVVDQMIKHDWSDNKDKEQPIGLVLLMAGVPNDVIQSMEKRIIP
SQ  GSPSGQILRSFFKMTPDNYKITGNLIEFIEVTVTADVARGVREKILKYQGGLEFIEQLLQIEAQKGNCQSGFRIKFDVVA
SQ  IRTDGSNISTQWPSRRNEGVVQAMRLIQADINFVREHLIKNDERGALEAMFNLKFHVTGPKVRTFDIPNYRPQQLCQPVL
SQ  ENLVEYCKNWLGTDHAFAFKEVTGQRVFNVFRDEEELHASKYGHSRKPRNFLLCQISLQVPYLPSTIASDQYDTRLACSE
SQ  ILKNYPETPLQLLARDMAYKYITLDNEDIINYYNPRVYFKPTQNIKEPGTFKLNLSNMDPKSKALIDVISKDSKKGVFGE
SQ  LIDSIDVASQVQQNECAKTIEKILSDLEVNLGDSTAGLDQPKRTTGVDDILRKFYDNELVKYLISVIRKTTARHLGHLLR
SQ  DITESLIAHAGLKRSKYWSAHGYAYGSVLLCILPSKSLEVAGSFIRFFTVFKEGLGLIDADNLDSKVEIDGVTWCFSKII
SQ  SLDLNRLLALNIAFEKSLLATATWFQYYTEDQGHFPLQHALRSVFAFHFLLATSQKMKLCAIFDNLRYLIPAVTSTYSGF
SQ  EPLIRKFFERPFKSALEVYLYNIIKTLLVSLAQNNKIRFYSRVRLLGLTVDQSSIGASGVYPSLMSRVVYKHYRSLISEA
SQ  TTCFFLFEKGLHGNLTEEAKIHLETVEWARKFREKERKLGSYIMEEGYHIQDVLNNQVVVEQQLFCQEVVELAAQELNTY
SQ  LHAKSQVMASNIMNKHWDKPYFSQTRNISLKGMSGALQEDGHLAASVTLIEAIRFLNHSQNNPTVLELYEQTKKQKAQAR
SQ  IVRKYQRTEADRGFFITTLPTRVRLEIIEDYYDAIARVVPEEYISYGGETKILNIQQALEKALRWASGESEIQSSIGHSI
SQ  KLKRKLMYVSADATKWSPGDNSAKFRRFTQSLYDGLRDDKLKNCVVDALRNIYETDFFISRKLHRYIDNMGELSDEVLDF
SQ  LSFFPNKVSASIKGNWLQGNLNKCSSLFGAAVSLLFKRVWAKLYPELECFFEFAHHSDDALFIYGYLEPVDDGTEWFQYV
SQ  TQQIQAGNFHWHAVNQEMWKSMFNLHEHILLMGSIKISPKKTTVSPTNAEFLSTFFEGCAVSIPFIKILLGSLSDLPGLG
SQ  YFDDLAAAQSRCVKALDMGACPQLAQLGIVLCTSKVERLYGTAPGMVNNPTAYLKVDRSLIPIPLGGDGSMSIMELATAG
SQ  IGMADKNILKNAFITYKHAKKDNDRYVLGLFKFLMSLSDDIFQHDRLGEFSFVGKVQWKVFTPKSEFEFYDQYSRKYLEL
SQ  WSEQHPVYDYIIPRGRDNLLVYLVRKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCKLDGEWVTFREVLAAADAFASEY
SQ  RPTLQDMELFQTLVNCTFSKEYAWRDFLNEVQCDVLTTRQIHRPKVARTFTVKEKDQTIQNPITAVIGYKYASKVDEISD
SQ  VLDSAIHPDSLSTDLQLMREGVYRELGLDISQPNVLKKVAPLLYKSGKSRIVIVQGNVEGTAESICSYWLKTMSLVKTIK
SQ  VKPKKEVLKAVSLYGKKEKAGDLTHLAAMRLCIEVWRWCKANEQDSVSWLKYLMFENKTLEQWIDSFCSRGVLPVDPEIQ
SQ  CLGLLVYDLKGQKGLLQIQANRRAYSGKQYDAYCVQTYNEETKLYEGDLRVTFNFGIDCARLEIFWDKREYILETSITQR
SQ  NVLKILMEEVTKELLRCGMRFKTEQVNSSRSVVLFKTESGFEWGKPNVPCIVYRNCTLRTGLRVRQPTNKAFSITIQANG
SQ  FRAMAQLDEENPRFLLAHAYHNLKDVRYQALQAVGNVWFKMTQHKLFINPIISAGLLENFMKGLPAAIPPAAYSLIMNKA
SQ  KISVDLFMFNELLALINPQNVLNLDGIEETSEGYTTVSTISSTQWSEEVSLTMDDSDDDGDASQLDYTIDLDDIDFETID
SQ  LKEDIEHFLQDESAYTGDLLIQTEETEIRKLRGMIKILEPVKLIKSWVSKGLSIDKIYNPVNIILMTRYMSKHYNFHAKQ
SQ  LSLMDPYDLTEFESIVKGWGECVKDRFIELDQEAQRKVTEERVLPEDVLPDSLFSFRHADILLKRLFPRDSASSFY
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