ID  P27314;
PN  cap-snatching endonuclease;
GN  L;
OS  12557;
SL  Nucleus Position: SL-0382;
SL  Comments: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q9YQR5}.
DR  UNIPROT: P27314;
DR  Pfam: PF04196;
DR  Pfam: PF12426;
DR  PROSITE: PS50525;
DE  Function: RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate (By similarity). During transcription, synthesizes subgenomic RNAs and assures their capping by a cap- snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. Cleaves ssRNA substrates but not DNA (By similarity). Seems to downregulate the expression of its own and heterologous mRNAs through its endonuclease activity (By similarity). {ECO:0000250|UniProtKB:Q9E005}.
DE  Reference Proteome: No;
GO  GO:0044220;
GO  GO:0004519;
GO  GO:0046872;
GO  GO:0000166;
GO  GO:0003968;
GO  GO:0075526;
GO  GO:0006351;
GO  GO:0039689;
GO  GO:0039696;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEKYREIHRDLKEFTINSLTAVECMDYLDRLYAVRHDIVDQMIKHEWSDNKDSEEPISKVLLFAGIPNNVITALEKKVIP
SQ  DHPSGKTLRSFFKMTPDNYRITGSLIEFVEVTVTADVDKGIREKKMKYELGLKYLEQELMTFFHRGELQNPYKITFKVVA
SQ  VRTDGSNISTQWPSARNDGVVQYMRLVQAEISYVREHLVKTEERAALEAMFNLKFNISSLKTQPYFIPEYKGIDLIRPDI
SQ  DGLVNYAQSWMSKTQEFSFFEVKGSAVFDCFNENEQGHIVKYPMSRHPRNFLLIQCTVLTAYKPATILSDQLDSRRACIQ
SQ  FLNLIPETPASILAHDMAHRYINLTRDDLLAYYAPRIQFNPTQNIKEPGTFKLTSNMMRPESKIMLDMLSQHEPRENLGK
SQ  SIESLNISSHIVQSDCVSLITKILSDLELNISEPSSHEQITAKHTHVDTVLDKFFQNETQKYLIDILKKTTAWHIGHLVR
SQ  DITESLIAHSGLRRSKYWSIHAYNNGSVILFILPSKSLEVAGSFVRFMTAFKLGPGLVDKDNLDSILADGDILWGVSKIM
SQ  SLDLNRLLALNIAFEKALLATATWFQYYTEDQSQFPLQHSIRSVFAYHFLLAICQKMKLCAIFDNLRYLIPAVTSLYSGF
SQ  PSLVEKLFERPFKSALEVYVYYNIKSLLVALAQNNKARFYSKVKLLGLTVDQSTVGASGIYPSFMSRVVYKHYKSLISEV
SQ  TTCFFLFEKGLHGNVNEEAKIHLETVEWATKFKEKEDKYGEMLVEHGYTIGELVESSELAVQQLYCQDAVELAANELNRV
SQ  LIAKSQVVANSILNKYWEEPYFSQTRNISLKGMSGQVQEDGHLSSSTTIIEAIRYLSNSRNNPNVLQLYEETRHQKAQAR
SQ  IVRKFQRTEADRGFFITTLPTRCRLEIIEDYYDAISKNVAEEYISYGGERKILCIQAALEKALRWASGESFIELSNGKFI
SQ  RMKRKLMYVSADATKWSPGDNSAKFRRFTAALHNGLPDDRLKNCVIDALRHVYKTDFYMSRKLRHYIDSMDTYEPHVRDF
SQ  LNFFPDGHHGEVRGNWLQGNLNKCSSLFGVAMSLLFKEIWTRLFPELDCFFEFAHHSDDALFIYGYLEPADDGTDWFLFV
SQ  SQQIQAGKLHWFNVNTEMWKSMFNLHEHILLLGSIKISPKKTTLSPTNAEFLSTFFEGCAVSIPFIKILLGSLSDLPGLG
SQ  YFDDLAAAQTRCVKAMDLGASPQISQLAVSLSTSKVERLYGTSIGMVNYPGTYLRTKHSETPIPLGGSGAMSIMELSTAG
SQ  IGMSDKNLLKQALIGYMHKHQKQMSYILGLFKFLMDLSGETFQHERLGQFSFIGKVQWKIFTPKSEFEFSDMYSQKFLKV
SQ  WSEQHPTYDYIIPKGRDNLLIYLVRKLNDPSIITAMTMQSPLQLRFRMQAKQHMKVCRLDGDWVTFREVLAAANSFAESY
SQ  EPSQNDIDLFQTLTSCTFSKEYAWKDFLNNVHCDVIPTKQVQRAKVARTFTVREKDRIIQNSIPAVIGYKFAVTVDEMSD
SQ  VLDTAKFPDSLAVDLKTMKDGVYRELGLDISSPDVMKKVAPMLYKSAKSRVVIVQGNVEGTAEAICAYWLRNMSLIKTIK
SQ  VKPHKEVLQAVSIFNRKEDIGQQKDLSALKLCIEVWRWAKANNAPYRDWFHALWFEDKTFSEWLDRFIRVGVPPIDPEIQ
SQ  CAALMIADVKGDRSVLQLQANRRAYSGKQYDAYCVQTYNEETKLYEGDLRVTFNFGLDCARLEIFWDKKTYILETSITQK
SQ  HVLKIMMEEVSKELVRCGMRFNTEQVNGVKHLVLFKTDSGFEWGKPNIPCIVYKNCALRTGLRTNQAINHKFMITIKDDG
SQ  LRAIAQYDEDSPRFLLAHAFHTIRDVRYQAVDAVSNVWFTHKGIKLYLNPIISSGLLEYFMKNIPAAIPPAAYSLIMNRA
SQ  KISVDLFMFNDLLRLINPGNTLDLSGLEITGEGYSTVNSLSSRLWSEEMSLVDDEEEMDDEFTIDLQDVDFENIDIEADV
SQ  EHFLQDESAYTGDLLIMSEETEVKKMRGIIKLLEPVKLIKSWVSRGLSIEKVYNPVNIILMTRYISKNFNFSGKQVSLLD
SQ  PYDLTELESIVKGWGESVVDQFDSLDLEAQNLVQKQGIVPEDVIPDSLFSFRHTMVLLRRLFGQDSVSTFY
//