ID  P27815;
PN  cAMP-specific 3',5'-cyclic phosphodiesterase 4A;
GN  PDE4A;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: [Isoform 1]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15738310}. [Isoform 2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15738310}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15738310}. [Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:7888306}. [Isoform 4]: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:9677330}. Note=Isoform 4 has propensity for association with membranes. {ECO:0000269|PubMed:9677330}. [Isoform 6]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}. [Isoform 7]: Cytoplasm, cytosol. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:18095939}. Note=Predominantly cytosolic. {ECO:0000269|PubMed:18095939}.
DR  UNIPROT: P27815;
DR  UNIPROT: O75522;
DR  UNIPROT: O76092;
DR  UNIPROT: Q16255;
DR  UNIPROT: Q16691;
DR  UNIPROT: Q5DM53;
DR  UNIPROT: Q6PMT2;
DR  UNIPROT: Q8IVA7;
DR  UNIPROT: Q8WUQ3;
DR  UNIPROT: Q9H3H2;
DR  PDB: 2QYK;
DR  PDB: 3I8V;
DR  PDB: 3TVX;
DR  Pfam: PF18100;
DR  Pfam: PF00233;
DR  PROSITE: PS00126;
DR  PROSITE: PS51845;
DR  OMIM: 600126;
DR  DisGeNET: 5141;
DE  Function: Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}. [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}. [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}. [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}. [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}. [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}. [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}.
DE  Reference Proteome: Yes;
DE  Interaction: P31016; IntAct: EBI-7970649; Score: 0.44
DE  Interaction: P27987; IntAct: EBI-11069427; Score: 0.35
DE  Interaction: Q9UJX0; IntAct: EBI-24327666; Score: 0.56
DE  Interaction: O14569; IntAct: EBI-24684076; Score: 0.56
DE  Interaction: P16118; IntAct: EBI-24601320; Score: 0.56
DE  Interaction: O75344; IntAct: EBI-21665235; Score: 0.35
DE  Interaction: P22626; IntAct: EBI-20929192; Score: 0.40
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: P55212; IntAct: EBI-25834679; Score: 0.56
DE  Interaction: P13473; IntAct: EBI-25872955; Score: 0.56
DE  Interaction: Q9Y371; IntAct: EBI-25921942; Score: 0.56
DE  Interaction: O75400; IntAct: EBI-25923927; Score: 0.56
DE  Interaction: Q13554; IntAct: EBI-28939469; Score: 0.35
DE  Interaction: Q13555; IntAct: EBI-28939534; Score: 0.35
DE  Interaction: Q13557; IntAct: EBI-28939579; Score: 0.35
DE  Interaction: Q9UQM7; IntAct: EBI-28947140; Score: 0.35
GO  GO:0005829;
GO  GO:0019898;
GO  GO:0016020;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0032587;
GO  GO:0004115;
GO  GO:0004114;
GO  GO:0030552;
GO  GO:0046872;
GO  GO:0006198;
GO  GO:0071466;
GO  GO:0007186;
GO  GO:0106070;
GO  GO:0010738;
GO  GO:0007608;
GO  GO:0007165;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:18095939};
SQ  MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLR
SQ  TTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKT
SQ  MSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
SQ  CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ
SQ  PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQ
SQ  ERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV
SQ  SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV
SQ  ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEK
SQ  SQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE
SQ  ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE
SQ  EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGG
SQ  SGGDPT
//