ID  P28662;
PN  Brain protein I3;
GN  Bri3;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Lysosome membrane {ECO:0000250|UniProtKB:O95415}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O95415}. Note=Co-localizes with MGAT1 and IFITM3 at the perinuclear region. {ECO:0000250|UniProtKB:O95415}.
DR  UNIPROT: P28662;
DR  UNIPROT: Q501N3;
DR  UNIPROT: Q9Z1S1;
DR  Pfam: PF10164;
DE  Function: Participates in tumor necrosis factor-alpha (TNF)-induced cell death (Ref.4). May be a target of Wnt/beta-catenin signaling in the liver (By similarity). {ECO:0000250|UniProtKB:O95415, ECO:0000269|Ref.4}.
DE  Reference Proteome: Yes;
GO  GO:0016021;
GO  GO:0005765;
GO  GO:0048471;
GO  GO:0042802;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPTAPPPPPYPYLVTGIPTSHPRVYNIHSRTVTRYPANSIVVVGGCPV
SQ  CRVGVLEYCFTCLGIFLAIVLFPFGFLCCFALRKRRCPNCGAVFT
//