ID  P30047;
PN  GTP cyclohydrolase 1 feedback regulatory protein;
GN  GCHFR;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus {ECO:0000269|PubMed:16778797}. Nucleus membrane {ECO:0000269|PubMed:16778797}. Cytoplasm, cytosol {ECO:0000269|PubMed:16778797}.
DR  UNIPROT: P30047;
DR  UNIPROT: B2R4L6;
DR  UNIPROT: B7ZLM8;
DR  UNIPROT: Q2M1Q2;
DR  UNIPROT: Q99749;
DR  PDB: 6Z80;
DR  PDB: 6Z85;
DR  PDB: 7ACC;
DR  PDB: 7AL9;
DR  PDB: 7ALA;
DR  PDB: 7ALB;
DR  PDB: 7ALC;
DR  PDB: 7ALQ;
DR  Pfam: PF06399;
DR  OMIM: 602437;
DR  DisGeNET: 2644;
DE  Function: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. {ECO:0000269|PubMed:16778797}.
DE  Reference Proteome: Yes;
DE  Interaction: O75147; IntAct: EBI-21786208; Score: 0.35
DE  Interaction: P30793; IntAct: EBI-958378; Score: 0.37
DE  Interaction: P20155; IntAct: EBI-21762493; Score: 0.35
DE  Interaction: Q8N0Z8; IntAct: EBI-21786208; Score: 0.35
DE  Interaction: Q9Y450; IntAct: EBI-21786208; Score: 0.35
DE  Interaction: Q96RR4; IntAct: EBI-21786208; Score: 0.35
DE  Interaction: Q7Z5L9; IntAct: EBI-21786208; Score: 0.35
DE  Interaction: Q5JSL3; IntAct: EBI-21786208; Score: 0.35
DE  Interaction: Q13951; IntAct: EBI-21786208; Score: 0.35
DE  Interaction: Q04637; IntAct: EBI-21786208; Score: 0.35
DE  Interaction: O76041; IntAct: EBI-21786208; Score: 0.35
DE  Interaction: O00168; IntAct: EBI-21862664; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0042470;
GO  GO:0031965;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0032991;
GO  GO:0016597;
GO  GO:0004857;
GO  GO:0044549;
GO  GO:0030742;
GO  GO:0044877;
GO  GO:0009890;
GO  GO:0043105;
GO  GO:0042133;
GO  GO:0006809;
GO  GO:0065003;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MPYLLISTQIRMEVGPTMVGDEQSDPELMQHLGASKRRALGNNFYEYYVDDPPRIVLDKLERRGFRVLSMTGVGQTLVWC
SQ  LHKE
//