ID  P30279;
PN  G1/S-specific cyclin-D2;
GN  CCND2;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus {ECO:0000269|PubMed:18827403}. Cytoplasm {ECO:0000269|PubMed:18827403}. Nucleus membrane {ECO:0000269|PubMed:18827403}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000269|PubMed:18827403}. [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17873913}.
DR  UNIPROT: P30279;
DR  UNIPROT: A8K531;
DR  UNIPROT: Q13955;
DR  UNIPROT: Q5U035;
DR  PDB: 6EI2;
DR  Pfam: PF02984;
DR  Pfam: PF00134;
DR  PROSITE: PS00292;
DR  OMIM: 123833;
DR  OMIM: 615938;
DR  DisGeNET: 894;
DE  Function: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739, PubMed:18827403). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739, PubMed:18827403). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739, PubMed:18827403). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739, PubMed:18827403). {ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:8114739}.
DE  Disease: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3) [MIM:615938]: A syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly- capillary malformation syndrome. {ECO:0000269|PubMed:24705253}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: P11802; IntAct: EBI-768365; Score: 0.93
DE  Interaction: P35227; IntAct: EBI-7823662; Score: 0.59
DE  Interaction: P38936; IntAct: EBI-756799; Score: 0.95
DE  Interaction: P46527; IntAct: EBI-758509; Score: 0.77
DE  Interaction: P24941; IntAct: EBI-1245720; Score: 0.55
DE  Interaction: Q00535; IntAct: EBI-6256270; Score: 0.96
DE  Interaction: Q00534; IntAct: EBI-6380828; Score: 0.35
DE  Interaction: Q5VK71; IntAct: EBI-11601998; Score: 0.40
DE  Interaction: Q8IWL3; IntAct: EBI-13943458; Score: 0.35
DE  Interaction: Q08999; IntAct: EBI-21848702; Score: 0.35
DE  Interaction: P49918; IntAct: EBI-21848702; Score: 0.35
DE  Interaction: P07550; IntAct: EBI-20801651; Score: 0.37
GO  GO:0000785;
GO  GO:0097129;
GO  GO:0000307;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0031965;
GO  GO:0005730;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0016538;
GO  GO:0019901;
GO  GO:0008344;
GO  GO:0051301;
GO  GO:0071481;
GO  GO:0000082;
GO  GO:0007616;
GO  GO:0044772;
GO  GO:0043066;
GO  GO:0008284;
GO  GO:0045737;
GO  GO:1900087;
GO  GO:0001934;
GO  GO:0000079;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLA
SQ  MNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFI
SQ  EHILRKLPQQREKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDV
SQ  DCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL
//