ID  P31689;
PN  DnaJ homolog subfamily A member 1;
GN  DNAJA1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Membrane {ECO:0000305|PubMed:10816573}; Lipid- anchor {ECO:0000305|PubMed:10816573}. Cytoplasm {ECO:0000269|PubMed:10816573}. Microsome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10816573}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10816573}. Mitochondrion {ECO:0000250}. Note=Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. {ECO:0000250}.
DR  UNIPROT: P31689;
DR  UNIPROT: Q5T7Q0;
DR  UNIPROT: Q86TL9;
DR  PDB: 2LO1;
DR  PDB: 2M6Y;
DR  PDB: 6E8M;
DR  Pfam: PF00226;
DR  Pfam: PF01556;
DR  Pfam: PF00684;
DR  PROSITE: PS00636;
DR  PROSITE: PS50076;
DR  PROSITE: PS51188;
DR  OMIM: 602837;
DR  DisGeNET: 3301;
DE  Function: Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co- chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.
DE  Reference Proteome: Yes;
DE  Interaction: A0A142I5B9; IntAct: EBI-20625330; Score: 0.35
DE  Interaction: O43542; IntAct: EBI-11129266; Score: 0.35
DE  Interaction: O95831; IntAct: EBI-16786283; Score: 0.27
DE  Interaction: P00533; IntAct: EBI-702075; Score: 0.35
DE  Interaction: P04626; IntAct: EBI-8770853; Score: 0.53
DE  Interaction: P05129; IntAct: EBI-25379555; Score: 0.35
DE  Interaction: P0DTD1; IntAct: EBI-25509375; Score: 0.35
DE  Interaction: Q9Y333; IntAct: EBI-348751; Score: 0.00
DE  Interaction: Q13233; IntAct: EBI-361839; Score: 0.00
DE  Interaction: Q99759; IntAct: EBI-362154; Score: 0.00
DE  Interaction: Q00653; IntAct: EBI-362743; Score: 0.00
DE  Interaction: Q99558; IntAct: EBI-362977; Score: 0.00
DE  Interaction: Q04206; IntAct: EBI-363259; Score: 0.00
DE  Interaction: Q13546; IntAct: EBI-363616; Score: 0.00
DE  Interaction: Q9Y572; IntAct: EBI-363772; Score: 0.00
DE  Interaction: Q15750; IntAct: EBI-363982; Score: 0.00
DE  Interaction: Q9NYJ8; IntAct: EBI-364051; Score: 0.00
DE  Interaction: O43318; IntAct: EBI-364144; Score: 0.00
DE  Interaction: P19438; IntAct: EBI-364369; Score: 0.00
DE  Interaction: P20333; IntAct: EBI-364603; Score: 0.00
DE  Interaction: Q15628; IntAct: EBI-364837; Score: 0.00
DE  Interaction: Q13077; IntAct: EBI-364942; Score: 0.00
DE  Interaction: Q12933; IntAct: EBI-365035; Score: 0.00
DE  Interaction: Q9Y4K3; IntAct: EBI-365134; Score: 0.00
DE  Interaction: A0JLT2; IntAct: EBI-394580; Score: 0.35
DE  Interaction: Q9NX70; IntAct: EBI-394875; Score: 0.35
DE  Interaction: Q8IXH7; IntAct: EBI-733541; Score: 0.00
DE  Interaction: P49703; IntAct: EBI-733840; Score: 0.00
DE  Interaction: P19256; IntAct: EBI-734132; Score: 0.00
DE  Interaction: P30408; IntAct: EBI-736034; Score: 0.00
DE  Interaction: Q9UM11; IntAct: EBI-736796; Score: 0.00
DE  Interaction: Q9NPF4; IntAct: EBI-1062592; Score: 0.00
DE  Interaction: O75365; IntAct: EBI-1068254; Score: 0.00
DE  Interaction: O00422; IntAct: EBI-1076324; Score: 0.00
DE  Interaction: P31930; IntAct: EBI-1078266; Score: 0.00
DE  Interaction: Q9Y2Q3; IntAct: EBI-1081237; Score: 0.00
DE  Interaction: Q92956; IntAct: EBI-1082988; Score: 0.00
DE  Interaction: P01889; IntAct: EBI-1083927; Score: 0.00
DE  Interaction: P13569; IntAct: EBI-1171566; Score: 0.64
DE  Interaction: Q9H9G7; IntAct: EBI-2267899; Score: 0.35
DE  Interaction: Q9HCK5; IntAct: EBI-2269711; Score: 0.35
DE  Interaction: P99024; IntAct: EBI-2555184; Score: 0.40
DE  Interaction: P05213; IntAct: EBI-2558640; Score: 0.40
DE  Interaction: Q9Z1B5; IntAct: EBI-2560653; Score: 0.40
DE  Interaction: P83887; IntAct: EBI-2561869; Score: 0.40
DE  Interaction: P68372; IntAct: EBI-2562208; Score: 0.40
DE  Interaction: Q13573; IntAct: EBI-7950968; Score: 0.35
DE  Interaction: Q99459; IntAct: EBI-7954144; Score: 0.35
DE  Interaction: Q9H492; IntAct: EBI-3044058; Score: 0.35
DE  Interaction: P60520; IntAct: EBI-3046676; Score: 0.35
DE  Interaction: O95166; IntAct: EBI-3050465; Score: 0.35
DE  Interaction: P15822; IntAct: EBI-3930535; Score: 0.37
DE  Interaction: Q13042; IntAct: EBI-3930976; Score: 0.37
DE  Interaction: Q15051; IntAct: EBI-4286917; Score: 0.35
DE  Interaction: P07900; IntAct: EBI-4310841; Score: 0.35
DE  Interaction: Q9Y276; IntAct: EBI-7104167; Score: 0.37
DE  Interaction: P51636; IntAct: EBI-7110722; Score: 0.37
DE  Interaction: P35914; IntAct: EBI-7174982; Score: 0.37
DE  Interaction: O95989; IntAct: EBI-7273627; Score: 0.37
DE  Interaction: Q9GZX7; IntAct: EBI-7553697; Score: 0.50
DE  Interaction: P0DOE9; IntAct: EBI-6138583; Score: 0.35
DE  Interaction: Q8JPQ9; IntAct: EBI-6159460; Score: 0.35
DE  Interaction: Q77M19; IntAct: EBI-6270503; Score: 0.35
DE  Interaction: Q13616; IntAct: EBI-21323857; Score: 0.35
DE  Interaction: Q92905; IntAct: EBI-21325777; Score: 0.35
DE  Interaction: Q13617; IntAct: EBI-21327106; Score: 0.35
DE  Interaction: Q13620; IntAct: EBI-21327757; Score: 0.35
DE  Interaction: Q13618; IntAct: EBI-21329068; Score: 0.35
DE  Interaction: Q93034; IntAct: EBI-21331078; Score: 0.35
DE  Interaction: Q92769; IntAct: EBI-6597828; Score: 0.35
DE  Interaction: Q9UBN7; IntAct: EBI-6597993; Score: 0.53
DE  Interaction: Q969S8; IntAct: EBI-6598258; Score: 0.35
DE  Interaction: Q96DB2; IntAct: EBI-6598272; Score: 0.35
DE  Interaction: Q7Z6J6; IntAct: EBI-6911571; Score: 0.35
DE  Interaction: Q15334; IntAct: EBI-6911667; Score: 0.35
DE  Interaction: P35240; IntAct: EBI-6911783; Score: 0.35
DE  Interaction: P21860; IntAct: EBI-8770321; Score: 0.35
DE  Interaction: P34969; IntAct: EBI-9027817; Score: 0.35
DE  Interaction: Q8WW22; IntAct: EBI-9393722; Score: 0.35
DE  Interaction: Q96BE0; IntAct: EBI-9394503; Score: 0.35
DE  Interaction: Q9Y266; IntAct: EBI-9395024; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-9515510; Score: 0.53
DE  Interaction: Q16659; IntAct: EBI-12502733; Score: 0.35
DE  Interaction: P57078; IntAct: EBI-12503575; Score: 0.35
DE  Interaction: Q13043; IntAct: EBI-10049645; Score: 0.35
DE  Interaction: P03372; IntAct: EBI-9996267; Score: 0.35
DE  Interaction: Q6ZMQ8; IntAct: EBI-10101253; Score: 0.35
DE  Interaction: P10398; IntAct: EBI-10101587; Score: 0.35
DE  Interaction: Q13418; IntAct: EBI-10103376; Score: 0.35
DE  Interaction: P51617; IntAct: EBI-10103481; Score: 0.53
DE  Interaction: P53671; IntAct: EBI-10103591; Score: 0.35
DE  Interaction: P04049; IntAct: EBI-10104226; Score: 0.35
DE  Interaction: Q96FW1; IntAct: EBI-10770028; Score: 0.35
DE  Interaction: P03179; IntAct: EBI-11721697; Score: 0.35
DE  Interaction: P03220; IntAct: EBI-11722152; Score: 0.35
DE  Interaction: P03225; IntAct: EBI-11722220; Score: 0.35
DE  Interaction: P06463; IntAct: EBI-11724048; Score: 0.35
DE  Interaction: P0CK49; IntAct: EBI-11725356; Score: 0.35
DE  Interaction: P0CK56; IntAct: EBI-11725466; Score: 0.35
DE  Interaction: P0CK58; IntAct: EBI-11732874; Score: 0.35
DE  Interaction: P30119; IntAct: EBI-11733103; Score: 0.35
DE  Interaction: P69901; IntAct: EBI-11733364; Score: 0.35
DE  Interaction: Q2MG95; IntAct: EBI-11733653; Score: 0.35
DE  Interaction: Q69117; IntAct: EBI-11733954; Score: 0.35
DE  Interaction: P05214; IntAct: EBI-10992821; Score: 0.35
DE  Interaction: P35550; IntAct: EBI-11044604; Score: 0.35
DE  Interaction: Q9BQE3; IntAct: EBI-11139064; Score: 0.35
DE  Interaction: O75665; IntAct: EBI-11365691; Score: 0.27
DE  Interaction: Q15468; IntAct: EBI-11383475; Score: 0.27
DE  Interaction: Q92834; IntAct: EBI-11394826; Score: 0.27
DE  Interaction: Q9C0F1; IntAct: EBI-11397104; Score: 0.27
DE  Interaction: Q9NXB0; IntAct: EBI-11397893; Score: 0.27
DE  Interaction: Q14CZ7; IntAct: EBI-11426979; Score: 0.35
DE  Interaction: Q9WMX2; IntAct: EBI-11513409; Score: 0.35
DE  Interaction: Q13509; IntAct: EBI-11897134; Score: 0.35
DE  Interaction: Q71U36; IntAct: EBI-11897791; Score: 0.57
DE  Interaction: P56945; IntAct: EBI-15099384; Score: 0.35
DE  Interaction: O14829; IntAct: EBI-14024386; Score: 0.35
DE  Interaction: Q9Y2T4; IntAct: EBI-14027932; Score: 0.42
DE  Interaction: Q8IVT5; IntAct: EBI-14035664; Score: 0.35
DE  Interaction: Q6IQ23; IntAct: EBI-16398399; Score: 0.35
DE  Interaction: Q05322; IntAct: EBI-15481401; Score: 0.35
DE  Interaction: Q9BXB4; IntAct: EBI-21817602; Score: 0.35
DE  Interaction: Q96SU4; IntAct: EBI-21817602; Score: 0.35
DE  Interaction: Q14249; IntAct: EBI-21817602; Score: 0.35
DE  Interaction: O95714; IntAct: EBI-21817602; Score: 0.35
DE  Interaction: P54645; IntAct: EBI-16361875; Score: 0.35
DE  Interaction: P80386; IntAct: EBI-16362252; Score: 0.35
DE  Interaction: Q14684; IntAct: EBI-16686997; Score: 0.35
DE  Interaction: Q6ZNJ1; IntAct: EBI-16749633; Score: 0.35
DE  Interaction: Q9H9B4; IntAct: EBI-16799442; Score: 0.27
DE  Interaction: P09622; IntAct: EBI-20304669; Score: 0.35
DE  Interaction: O00429; IntAct: EBI-20305770; Score: 0.35
DE  Interaction: P08559; IntAct: EBI-20306509; Score: 0.35
DE  Interaction: Q86U44; IntAct: EBI-20594935; Score: 0.35
DE  Interaction: Q9HCE5; IntAct: EBI-20595531; Score: 0.35
DE  Interaction: P10636; IntAct: EBI-20799058; Score: 0.35
DE  Interaction: A2A935; IntAct: EBI-21022882; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: Q9Y251; IntAct: EBI-21260107; Score: 0.35
DE  Interaction: Q9HC29; IntAct: EBI-21262102; Score: 0.35
DE  Interaction: Q15077; IntAct: EBI-21262943; Score: 0.35
DE  Interaction: P03427; IntAct: EBI-21268420; Score: 0.35
DE  Interaction: P05067; IntAct: EBI-21132308; Score: 0.35
DE  Interaction: P49768; IntAct: EBI-21132675; Score: 0.35
DE  Interaction: P42858; IntAct: EBI-21132926; Score: 0.67
DE  Interaction: Q16526; IntAct: EBI-21981854; Score: 0.35
DE  Interaction: O15524; IntAct: EBI-25373793; Score: 0.35
DE  Interaction: Q13163; IntAct: EBI-25374437; Score: 0.35
DE  Interaction: Q13164; IntAct: EBI-25374538; Score: 0.35
DE  Interaction: P41240; IntAct: EBI-25376544; Score: 0.35
DE  Interaction: P46734; IntAct: EBI-25377403; Score: 0.35
DE  Interaction: Q02156; IntAct: EBI-25378052; Score: 0.35
DE  Interaction: P19419; IntAct: EBI-25378580; Score: 0.35
DE  Interaction: Q13153; IntAct: EBI-25379067; Score: 0.35
DE  Interaction: Q05513; IntAct: EBI-25380056; Score: 0.35
DE  Interaction: P41743; IntAct: EBI-25380638; Score: 0.35
DE  Interaction: P30530; IntAct: EBI-25383128; Score: 0.35
DE  Interaction: Q13882; IntAct: EBI-25385709; Score: 0.35
DE  Interaction: P15498; IntAct: EBI-25385501; Score: 0.35
DE  Interaction: P36507; IntAct: EBI-25391779; Score: 0.35
DE  Interaction: Q9H1R3; IntAct: EBI-25392649; Score: 0.35
DE  Interaction: P61586; IntAct: EBI-25394264; Score: 0.35
DE  Interaction: P06239; IntAct: EBI-25394571; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: P83110; IntAct: EBI-25471693; Score: 0.35
DE  Interaction: P69479; IntAct: EBI-25568051; Score: 0.35
DE  Interaction: P0DTC3; IntAct: EBI-25510118; Score: 0.35
DE  Interaction: P0DTD8; IntAct: EBI-25510237; Score: 0.35
DE  Interaction: P0DTC8; IntAct: EBI-25510273; Score: 0.35
DE  Interaction: Q96CS3; IntAct: EBI-25770166; Score: 0.35
DE  Interaction: O60260; IntAct: EBI-25879547; Score: 0.56
DE  Interaction: Q6PB30; IntAct: EBI-26354359; Score: 0.35
DE  Interaction: Q9Y5P2; IntAct: EBI-26354638; Score: 0.35
DE  Interaction: P52298; IntAct: EBI-26399642; Score: 0.35
DE  Interaction: Q8TB24; IntAct: EBI-26518569; Score: 0.35
DE  Interaction: P48431; IntAct: EBI-26574478; Score: 0.35
DE  Interaction: O60303; IntAct: EBI-26582514; Score: 0.35
DE  Interaction: Q9NRI5; IntAct: EBI-26610886; Score: 0.35
DE  Interaction: A0A0H3NJM6; IntAct: EBI-27055978; Score: 0.27
DE  Interaction: A0A0H3NB75; IntAct: EBI-27055983; Score: 0.27
DE  Interaction: P35226; IntAct: EBI-27109494; Score: 0.35
DE  Interaction: P22612; IntAct: EBI-28934688; Score: 0.35
DE  Interaction: Q8NCK7; IntAct: EBI-27103180; Score: 0.35
DE  Interaction: A4FU01; IntAct: EBI-27113520; Score: 0.35
DE  Interaction: A6NLX3; IntAct: EBI-28997370; Score: 0.35
DE  Interaction: Q9BXK1; IntAct: EBI-29019783; Score: 0.35
DE  Interaction: P04637; IntAct: EBI-29628346; Score: 0.35
DE  Interaction: P11362; IntAct: EBI-32718427; Score: 0.42
DE  Interaction: P08069; IntAct: EBI-32718669; Score: 0.35
DE  Interaction: P06213; IntAct: EBI-32718777; Score: 0.35
DE  Interaction: P04629; IntAct: EBI-32719115; Score: 0.42
DE  Interaction: Q16288; IntAct: EBI-32719212; Score: 0.35
DE  Interaction: Q01974; IntAct: EBI-32719482; Score: 0.35
DE  Interaction: Q06418; IntAct: EBI-32719716; Score: 0.35
DE  Interaction: P35916; IntAct: EBI-32722728; Score: 0.27
GO  GO:0005737;
GO  GO:0098554;
GO  GO:0005829;
GO  GO:0070062;
GO  GO:0016020;
GO  GO:0015630;
GO  GO:0005739;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005524;
GO  GO:0001671;
GO  GO:0055131;
GO  GO:0051087;
GO  GO:0001664;
GO  GO:0030544;
GO  GO:0050750;
GO  GO:0046872;
GO  GO:0030957;
GO  GO:0031625;
GO  GO:0051082;
GO  GO:0030521;
GO  GO:0030317;
GO  GO:0043066;
GO  GO:1903748;
GO  GO:0043508;
GO  GO:1905259;
GO  GO:0031397;
GO  GO:0043065;
GO  GO:0006457;
GO  GO:0070585;
GO  GO:0042026;
GO  GO:0051223;
GO  GO:0009408;
GO  GO:0006986;
GO  GO:0007283;
GO  GO:1901998;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:14752510,};
SQ  MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKKRELYDKGGEQAIKEGGAGGG
SQ  FGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQI
SQ  RIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDII
SQ  IVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRL
SQ  IIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
//