ID  P32567;
PN  Phosphatidic acid phosphohydrolase 1;
GN  PAH1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
DR  UNIPROT: P32567;
DR  UNIPROT: D6VZY7;
DR  Pfam: PF04571;
DR  Pfam: PF08235;
DE  Function: Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol (PubMed:16467296, PubMed:16968695, PubMed:17910939, PubMed:17971454, PubMed:20876142, PubMed:21081492, PubMed:29765047). Required for de novo lipid synthesis and formation of lipid droplets (PubMed:21422231). Controls transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope (PubMed:15889145). Involved in plasmid maintenance, in respiration and in cell proliferation (PubMed:8437575). {ECO:0000269|PubMed:15889145, ECO:0000269|PubMed:16467296, ECO:0000269|PubMed:16968695, ECO:0000269|PubMed:17910939, ECO:0000269|PubMed:17971454, ECO:0000269|PubMed:20876142, ECO:0000269|PubMed:21081492, ECO:0000269|PubMed:21422231, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:8437575}.
DE  Reference Proteome: Yes;
DE  Interaction: P30822; IntAct: EBI-11611503; Score: 0.35
DE  Interaction: P35719; IntAct: EBI-390744; Score: 0.37
DE  Interaction: P16140; IntAct: EBI-809535; Score: 0.35
DE  Interaction: P07259; IntAct: EBI-809535; Score: 0.35
DE  Interaction: P02557; IntAct: EBI-809535; Score: 0.35
DE  Interaction: P09733; IntAct: EBI-809535; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-809535; Score: 0.53
DE  Interaction: P10592; IntAct: EBI-809535; Score: 0.53
DE  Interaction: P00549; IntAct: EBI-809535; Score: 0.35
DE  Interaction: P40038; IntAct: EBI-2612835; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3721470; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3752559; Score: 0.35
DE  Interaction: Q06677; IntAct: EBI-3758717; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005789;
GO  GO:0019898;
GO  GO:0005811;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0005773;
GO  GO:0008195;
GO  GO:0000976;
GO  GO:0009060;
GO  GO:0044255;
GO  GO:0009062;
GO  GO:0034389;
GO  GO:0008654;
GO  GO:0006276;
GO  GO:0019432;
GO  GO:0042144;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MQYVGRALGSVSKTWSSINPATLSGAIDVIVVEHPDGRLSCSPFHVRFGKFQILKPSQKKVQVFINEKLSNMPMKLSDSG
SQ  EAYFVFEMGDQVTDVPDELLVSPVMSATSSPPQSPETSILEGGTEGEGEGENENKKKEKKVLEEPDFLDINDTGDSGSKN
SQ  SETTGSLSPTESSTTTPPDSVEERKLVEQRTKNFQQKLNKKLTEIHIPSKLDNNGDLLLDTEGYKPNKNMMHDTDIQLKQ
SQ  LLKDEFGNDSDISSFIKEDKNGNIKIVNPYEHLTDLSPPGTPPTMATSGSVLGLDAMESGSTLNSLSSSPSGSDTEDETS
SQ  FSKEQSSKSEKTSKKGTAGSGETEKRYIRTIRLTNDQLKCLNLTYGENDLKFSVDHGKAIVTSKLFVWRWDVPIVISDID
SQ  GTITKSDALGHVLAMIGKDWTHLGVAKLFSEISRNGYNILYLTARSAGQADSTRSYLRSIEQNGSKLPNGPVILSPDRTM
SQ  AALRREVILKKPEVFKIACLNDIRSLYFEDSDNEVDTEEKSTPFFAGFGNRITDALSYRTVGIPSSRIFTINTEGEVHME
SQ  LLELAGYRSSYIHINELVDHFFPPVSLDSVDLRTNTSMVPGSPPNRTLDNFDSEITSGRKTLFRGNQEEKFTDVNFWRDP
SQ  LVDIDNLSDISNDDSDNIDEDTDVSQQSNISRNRANSVKTAKVTKAPQRNVSGSTNNNEVLAASSDVENASDLVSSHSSS
SQ  GSTPNKSTMSKGDIGKQIYLELGSPLASPKLRYLDDMDDEDSNYNRTKSRRASSAAATSIDKEFKKLSVSKAGAPTRIVS
SQ  KINVSNDVHSLGNSDTESRREQSVNETGRNQLPHNSMDDKDLDSRVSDEFDDDEFDEDEFED
//