ID  P33175;
PN  Kinesin heavy chain isoform 5A;
GN  Kif5a;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6QLM7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6QLM7}. Perikaryon {ECO:0000250|UniProtKB:Q6QLM7}. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region. {ECO:0000250|UniProtKB:Q6QLM7}.
DR  UNIPROT: P33175;
DR  UNIPROT: Q5DTP1;
DR  UNIPROT: Q6PDY7;
DR  UNIPROT: Q9Z2F9;
DR  Pfam: PF00225;
DR  PROSITE: PS00411;
DR  PROSITE: PS50067;
DE  Function: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (PubMed:12682084). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons (PubMed:21976701). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). {ECO:0000250|UniProtKB:Q6QLM7, ECO:0000269|PubMed:12682084, ECO:0000269|PubMed:21976701}.
DE  Reference Proteome: Yes;
DE  Interaction: O08788; IntAct: EBI-8013466; Score: 0.40
DE  Interaction: Q61026; IntAct: EBI-8310937; Score: 0.37
DE  Interaction: O70585; IntAct: EBI-349734; Score: 0.70
DE  Interaction: O35668; IntAct: EBI-8013423; Score: 0.40
DE  Interaction: Q96NW4; IntAct: EBI-6125974; Score: 0.52
DE  Interaction: P50516; IntAct: EBI-6272793; Score: 0.35
DE  Interaction: P54256; IntAct: EBI-9652128; Score: 0.40
DE  Interaction: P35922; IntAct: EBI-16728828; Score: 0.35
DE  Interaction: P83510; IntAct: EBI-16734044; Score: 0.35
DE  Interaction: Q62108; IntAct: EBI-16724752; Score: 0.35
DE  Interaction: Q9D415; IntAct: EBI-16725590; Score: 0.35
DE  Interaction: Q4ACU6; IntAct: EBI-26572965; Score: 0.35
GO  GO:0097440;
GO  GO:0030424;
GO  GO:1904115;
GO  GO:0090724;
GO  GO:0035253;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0032839;
GO  GO:0005871;
GO  GO:0005874;
GO  GO:0043005;
GO  GO:0043025;
GO  GO:0000932;
GO  GO:0043204;
GO  GO:0048471;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0019894;
GO  GO:0008017;
GO  GO:0003777;
GO  GO:0008574;
GO  GO:0044877;
GO  GO:0097110;
GO  GO:0099641;
GO  GO:0098971;
GO  GO:0007411;
GO  GO:0030705;
GO  GO:0007018;
GO  GO:1990049;
GO  GO:0048489;
GO  GO:0016192;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVIIGGKPYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNG
SQ  TIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDK
SQ  NRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENVETEQKLSGKLYLVDLAGSEKVS
SQ  KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMF
SQ  GQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEDSALGAELCEETPVN
SQ  DNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAA
SQ  KDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMRDLSE
SQ  FSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKI
SQ  RSLTEYMQTVELKKRHLEESYDSLSDELARLQAHETVHEVALKDKEPDTQDAEEVKKALELQMENHREAHHRQLARLRDE
SQ  INEKQKTIDELKDLNQKLQLELEKLQADYERLKNEENEKSAKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKL
SQ  FVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALK
SQ  EAKEGAMKDKRRYQQEVDRIKEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNNLFQNYQNLHLQ
SQ  AAPSSTSDMYFASSGATSVAPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQAKLFPLHQETAAS
//