ID  P34077;
PN  Nucleoporin NIC96;
GN  NIC96;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
DR  UNIPROT: P34077;
DR  UNIPROT: D6VTN2;
DR  PDB: 2QX5;
DR  PDB: 2RFO;
DR  PDB: 6X07;
DR  PDB: 7N85;
DR  PDB: 7N9F;
DR  PDB: 7WOO;
DR  PDB: 7WOT;
DR  Pfam: PF04097;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NIC96, which is localized to the core of the NPC and the distal ring of the nuclear basket, is required for de novo assembly of NPCs. It is involved in nuclear GSP1 import. {ECO:0000269|PubMed:10428845, ECO:0000269|PubMed:10617624, ECO:0000269|PubMed:10684247, ECO:0000269|PubMed:10806080, ECO:0000269|PubMed:11121302, ECO:0000269|PubMed:11689687, ECO:0000269|PubMed:12403813, ECO:0000269|PubMed:12496130, ECO:0000269|PubMed:12730220, ECO:0000269|PubMed:7828598, ECO:0000269|PubMed:8682855, ECO:0000269|PubMed:9017593}.
DE  Reference Proteome: Yes;
DE  Interaction: P14907; IntAct: EBI-789044; Score: 0.35
DE  Interaction: P32499; IntAct: EBI-6322501; Score: 0.00
DE  Interaction: P32500; IntAct: EBI-6322567; Score: 0.00
DE  Interaction: Q03790; IntAct: EBI-390816; Score: 0.67
DE  Interaction: P53271; IntAct: EBI-390819; Score: 0.37
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.32
DE  Interaction: P07259; IntAct: EBI-789044; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-789044; Score: 0.35
DE  Interaction: P48837; IntAct: EBI-789044; Score: 0.84
DE  Interaction: Q02199; IntAct: EBI-789044; Score: 0.62
DE  Interaction: P47054; IntAct: EBI-789044; Score: 0.55
DE  Interaction: P40069; IntAct: EBI-789044; Score: 0.35
DE  Interaction: P53863; IntAct: EBI-797840; Score: 0.35
DE  Interaction: P40066; IntAct: EBI-813993; Score: 0.27
DE  Interaction: Q07953; IntAct: EBI-857992; Score: 0.00
DE  Interaction: Q02630; IntAct: EBI-1269736; Score: 0.00
DE  Interaction: Q02629; IntAct: EBI-1269879; Score: 0.00
DE  Interaction: P51998; IntAct: EBI-2347558; Score: 0.37
DE  Interaction: P23291; IntAct: EBI-2614250; Score: 0.35
DE  Interaction: P26448; IntAct: EBI-2882390; Score: 0.00
DE  Interaction: Q00684; IntAct: EBI-2882792; Score: 0.00
DE  Interaction: P22696; IntAct: EBI-2883245; Score: 0.00
DE  Interaction: P02293; IntAct: EBI-2884858; Score: 0.00
DE  Interaction: P38265; IntAct: EBI-2885494; Score: 0.00
DE  Interaction: P39723; IntAct: EBI-2887969; Score: 0.00
DE  Interaction: Q04477; IntAct: EBI-2887856; Score: 0.00
DE  Interaction: P46675; IntAct: EBI-2888241; Score: 0.00
DE  Interaction: P52593; IntAct: EBI-4324997; Score: 0.37
DE  Interaction: P52919; IntAct: EBI-7042849; Score: 0.27
DE  Interaction: Q7Z3B4; IntAct: EBI-11889076; Score: 0.37
DE  Interaction: Q05166; IntAct: EBI-11889154; Score: 0.37
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044612;
GO  GO:0044615;
GO  GO:0017056;
GO  GO:0006999;
GO  GO:0006913;
GO  GO:0016973;
GO  GO:0006606;
GO  GO:0000055;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MLETLRGNKLHSGTSKGANKKLNELLESSDNLPSASSELGSIQVSINELRRRVFQLRSKNKASKDYTKAHYLLANSGLSF
SQ  EDVDAFIKDLQTNQFLEPNPPKIIESEELEFYIRTKKEENILMSIEQLLNGATKDFDNFINHNLNLDWAQHKNEVMKNFG
SQ  ILIQDKKTVDHKKSISSLDPKLPSWGNKGNNILNSNESRLNVNENNILREKFENYARIVFQFNNSRQANGNFDIANEFIS
SQ  ILSSANGTRNAQLLESWKILESMKSKDINIVEVGKQYLEQQFLQYTDNLYKKNMNEGLATNVNKIKSFIDTKLKKADKSW
SQ  KISNLTVINGVPIWALIFYLLRAGLIKEALQVLVENKANIKKVEQSFLTYFKAYASSKDHGLPVEYSTKLHTEYNQHIKS
SQ  SLDGDPYRLAVYKLIGRCDLSRKNIPAVTLSIEDWLWMHLMLIKEKDAENDPVYERYSLEDFQNIIISYGPSRFSNYYLQ
SQ  TLLLSGLYGLAIDYTYTFSEMDAVHLAIGLASLKLFKIDSSTRLTKKPKRDIRFANILANYTKSFRYSDPRVAVEYLVLI
SQ  TLNEGPTDVELCHEALRELVLETKEFTVLLGKIGRDGARIPGVIEERQPLLHVRDEKEFLHTITEQAARRADEDGRIYDS
SQ  ILLYQLAEEYDIVITLVNSLLSDTLSASDLDQPLVGPDDNSETNPVLLARRMASIYFDNAGISRQIHVKNKEICMLLLNI
SQ  SSIRELYFNKQWQETLSQMELLDLLPFSDELSARKKAQDFSNLDDNIVKNIPNLLIITLSCISNMIHILNESKYQSSTKG
SQ  QQIDSLKNVARQCMIYAGMIQYRMPRETYSTLINIDVSL
//