ID  P34609;
PN  JNK-interacting protein;
GN  unc;
OS  6239;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10393177, ECO:0000269|PubMed:11738026}. Note=Diffusely localized throughout cell body but intensely localized in regions adjacent to nucleus and at presumptive tips of neural processes.
DR  UNIPROT: P34609;
DR  UNIPROT: A7LPE3;
DR  UNIPROT: A7LPE4;
DR  UNIPROT: C0P271;
DR  UNIPROT: C7FZT6;
DR  UNIPROT: Q95V72;
DR  UNIPROT: S6EZN6;
DR  UNIPROT: S6EZP3;
DR  UNIPROT: S6F548;
DR  UNIPROT: S6F556;
DR  UNIPROT: S6FD02;
DR  UNIPROT: S6FN04;
DR  UNIPROT: S6FN08;
DR  UNIPROT: S6FWP4;
DR  UNIPROT: S6FWP6;
DR  UNIPROT: U4MKU8;
DR  Pfam: PF16471;
DR  Pfam: PF09744;
DR  PROSITE: PS51776;
DR  PROSITE: PS51777;
DE  Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Regulates the retrograde transport of autophagosomes from the neurites to the cell body of AIY interneurons (PubMed:30880001). {ECO:0000269|PubMed:10393177, ECO:0000269|PubMed:11738026, ECO:0000269|PubMed:30880001}.
DE  Reference Proteome: Yes;
DE  Interaction: P46822; IntAct: EBI-2413629; Score: 0.62
DE  Interaction: Q5WRT0; IntAct: EBI-337898; Score: 0.00
DE  Interaction: H2L0F6; IntAct: EBI-343424; Score: 0.00
DE  Interaction: P34686; IntAct: EBI-345569; Score: 0.00
DE  Interaction: Q93345; IntAct: EBI-345563; Score: 0.00
DE  Interaction: Q18668; IntAct: EBI-345566; Score: 0.00
DE  Interaction: Q8WQG9; IntAct: EBI-1811901; Score: 0.40
DE  Interaction: G5EDT6; IntAct: EBI-1811913; Score: 0.40
GO  GO:0030424;
GO  GO:0043194;
GO  GO:0043679;
GO  GO:0044297;
GO  GO:0005737;
GO  GO:0048471;
GO  GO:0008432;
GO  GO:0019900;
GO  GO:0019894;
GO  GO:0005078;
GO  GO:0030159;
GO  GO:0030421;
GO  GO:0040011;
GO  GO:0018991;
GO  GO:0046328;
GO  GO:0030431;
GO  GO:0048489;
GO  GO:0016192;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MACNLSPVNEMADSITSSTPSEIVYGGPGSPDEHRTMSDKVQTMASAIYRELETMIKVHGEDGVKTLMPLVVNVLEALDL
SQ  AYLERDEQTAELEMLKEDNEQLQTQYEREKALRKQTEQKYIEIEDTLIGQNKELDKKIESLESIMRMLELKAKNATDHAS
SQ  RLEEREVEQKLEFDRLHERYNTLLRTHVDHMERTKYLMGSEKFELMQNMPLPNMQLRNKMGMAASVDASSIRGVSDLISA
SQ  HMTQSTTMDVNLANHITNEDWQDEFSSDIEPSPRDIPQSSADALTSPITTKEPTPKREAASPKQSEEEEADETTSVDPKE
SQ  NNDLLGADLTDDESDWNGLGLIPRRHRPNEMLDDDDTSDDGSLGMGREVENLIKENSELLDMKNALNIVKNDLINQVDEL
SQ  NSENMILRDENLSRQMVSEKMQEQITKHEEEIKTLKQKLMEKENEQEEDDVPMAMRKRFTRSEMQRVLMDRNAYKEKLME
SQ  LEESIKWTEMQRAKKMQQQQQNVNQKKSGGIWEFFSSLLGDSVTPPASSRGNRASSSRGKMTRSVEYIDPDMISERRAAE
SQ  RREQYKLVREHVKKEDGRIEAYGWSLPNVEAEVSSVPIPVCCRPLLDNEPSLKIWCATGVVLRGGRDERGQWIVGDPIYF
SQ  APASMKKTKTSNHRPELEDEIKRARNLDARESELDEWQSSSLVWVVSSNQGKSLIAVLDANNPNNIIETFPACDSHLLCI
SQ  QAVSGVMEGEPEMNEEQSKKYLSGGGKIKDLPEGLDGTDLGACEWVELRKMEDSEDGVPTYCSNDMKPSPKRTRDFSISE
SQ  VAPVDSSAPVKEDPLPPPANRPGGRAALPPHIRDAMSKYDGVSGQMSGALPTVWMGGQNQYIYIHSAVTAWKQCLRRIKM
SQ  PDAVLSIVHYKSRIFAALANGTIAIFHRNKHGEWSDEGYHSLRVGSATSSVRSLCLVSTNIWATYKNCVVVLDAESLQIV
SQ  KVFAAHPRKDSQVRNMQWVGAGVWLSIRLDSTLRLYHAHTYEHLQDVDIEPYVTKMLGTSKLDFSYMRTTALLVSNRRLW
SQ  IGTGTGVIISVPFSGQLEKKIETKDSKRPAGPGGLVRVYGATSENATNDEKTNDDFIPYCNLAHAQLSFHGHKDSVKFFL
SQ  GVPGASKNGEDESAEVTLRRMLIMSGGDGYIDFRIGEENEPELTGQSIRPRDMSHLIIWEVDAELPILSK
//