ID  P34689;
PN  ATP-dependent RNA helicase glh-1;
GN  glh;
OS  6239;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:17699606, ECO:0000269|PubMed:21402787}. Cytoplasmic granule {ECO:0000269|PubMed:17699606}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17699606}. Note=Perinuclear localization in germ cells but disperses into particles in cellularized oocytes. Component of P granules. {ECO:0000269|PubMed:17699606}.
DR  UNIPROT: P34689;
DR  UNIPROT: Q22873;
DR  UNIPROT: Q7KQH5;
DR  UNIPROT: Q9TXH4;
DR  Pfam: PF00270;
DR  Pfam: PF00271;
DR  Pfam: PF00098;
DR  PROSITE: PS00039;
DR  PROSITE: PS51192;
DR  PROSITE: PS51194;
DR  PROSITE: PS51195;
DR  PROSITE: PS50158;
DE  Function: Probable ATP-binding RNA helicase (PubMed:8415696). May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos (PubMed:21402787, PubMed:24746798). Plays a role in positively regulating the localization of pgl-1 to P-granules (PubMed:18234720). May play a role in transgenerational epigenetic inheritance (PubMed:28533440). May protect somatic cells from excessive apoptosis during normal development (PubMed:27650246). {ECO:0000269|PubMed:18234720, ECO:0000269|PubMed:21402787, ECO:0000269|PubMed:24746798, ECO:0000269|PubMed:27650246, ECO:0000305|PubMed:28533440, ECO:0000305|PubMed:8415696}.
DE  Reference Proteome: Yes;
DE  Interaction: P91001; IntAct: EBI-1571788; Score: 0.51
DE  Interaction: O44408; IntAct: EBI-1571866; Score: 0.40
DE  Interaction: Q9U3F4; IntAct: EBI-1571938; Score: 0.40
DE  Interaction: P34689; IntAct: EBI-1571975; Score: 0.40
DE  Interaction: O01836; IntAct: EBI-1571991; Score: 0.40
GO  GO:0005737;
GO  GO:0005634;
GO  GO:0043186;
GO  GO:0048471;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0017151;
GO  GO:0008432;
GO  GO:0043621;
GO  GO:0003723;
GO  GO:0003724;
GO  GO:0008270;
GO  GO:0030154;
GO  GO:0007276;
GO  GO:0007281;
GO  GO:0009791;
GO  GO:0016070;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSDGWSDSESAAKAKTGFGSGGGFGGGNNGGSGFGGGKNGGTGFGGGNTGGSGFGGGNTGGSGFGGGKTGGSGFGGGNTC
SQ  GSGFGGGSTGGSPYGGASSGFGGSTATSGFGSGEKSSAFGGSGGFGGSATGFGSGGGSFGGGNSGFGEGGHGGGERNNNC
SQ  FNCQQPGHRSSDCPEPRKEREPRVCYNCQQPGHTSRECTEERKPREGRTGGFGGGAGFGNNGGNDGFGGDGGFGGGEERG
SQ  PMKCFNCKGEGHRSAECPEPPRGCFNCGEQGHRSNECPNPAKPREGVEGEGPKATYVPVEDNMEDVFNMQKISEGLMFNK
SQ  FFDAEVKLTSSEKTVGIKPCKTFAEANLTETMQKNVAHAGYSKTTPIQQYALPLVHQGYDIMACAQTGSGKTAAFLLPIM
SQ  TRLIDDNNLNTAGEGGCYPRCIILTPTRELADQIYNEGRKFAYQTMMEIKPVYGGLAVGYNKGQIEKGATIIVGTVGRIK
SQ  HFCEEGTIKLDKCRFFVLDEADRMIDAMGFGTDIETIVNYDSMPRKENRQTLMFSATFPDSVQEAARAFLRENYVMIAID
SQ  KIGAANKCVLQEFERCERSEKKDKLLELLGIDIDSYTTEKSAEVYTKKTMVFVSQRAMADTLASILSSAQVPAITIHGAR
SQ  EQRERSEALRQFRNGSKPVLIATAVAERGLDIKGVDHVINYDMPDNIDDYIHRIGRTGRVGNSGRATSFISEDCSLLSEL
SQ  VGVLADAQQIVPDWMQGAAGGNYGASGFGSSVPTQVPQDEEGW
//