ID  P35197;
PN  ADP-ribosylation factor GTPase-activating protein GCS1;
GN  GCS1;
OS  559292;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:11839779}. Mitochondrion {ECO:0000269|PubMed:11839779}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11839779}. Golgi apparatus {ECO:0000305|PubMed:11839779}. Note=Found also in the mitochondria and in the perinuclear region.
DR  UNIPROT: P35197;
DR  UNIPROT: D6VRC9;
DR  PDB: 5FJX;
DR  Pfam: PF01412;
DR  PROSITE: PS50115;
DE  Function: GTPase-activating protein (GAP) for ARF1 and ARF2. Involved in intracellular vesicular transport. Required for transport from the trans-Golgi network. Implicated in the regulation of retrograde transport from the Golgi to the ER and in actin cytoskeletal organization. May be involved in the maintenance of mitochondrial morphology, possibly through organizing the actin cytoskeleton in Saccharomyces. {ECO:0000269|PubMed:11756474, ECO:0000269|PubMed:11839779, ECO:0000269|PubMed:9927415}.
DE  Reference Proteome: Yes;
DE  Interaction: P84077; IntAct: EBI-620364; Score: 0.37
DE  Interaction: P16140; IntAct: EBI-785523; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-785523; Score: 0.53
DE  Interaction: P53919; IntAct: EBI-858904; Score: 0.00
DE  Interaction: P10591; IntAct: EBI-3670433; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3688456; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3725254; Score: 0.35
DE  Interaction: Q12136; IntAct: EBI-16255956; Score: 0.00
DE  Interaction: P38169; IntAct: EBI-16257096; Score: 0.00
DE  Interaction: P39981; IntAct: EBI-16257116; Score: 0.00
DE  Interaction: P40073; IntAct: EBI-16257136; Score: 0.00
DE  Interaction: P53108; IntAct: EBI-16257156; Score: 0.00
DE  Interaction: P53093; IntAct: EBI-16257176; Score: 0.00
DE  Interaction: P53039; IntAct: EBI-16257196; Score: 0.00
DE  Interaction: P14359; IntAct: EBI-16257216; Score: 0.00
DE  Interaction: P12688; IntAct: EBI-16257236; Score: 0.00
DE  Interaction: P36164; IntAct: EBI-16257256; Score: 0.00
DE  Interaction: Q12016; IntAct: EBI-16257276; Score: 0.00
DE  Interaction: P33328; IntAct: EBI-16257296; Score: 0.00
DE  Interaction: P06197; IntAct: EBI-16257316; Score: 0.00
DE  Interaction: P14020; IntAct: EBI-16257336; Score: 0.00
GO  GO:0005856;
GO  GO:0005829;
GO  GO:0005768;
GO  GO:0005739;
GO  GO:0048471;
GO  GO:0005802;
GO  GO:0003779;
GO  GO:0005096;
GO  GO:0046872;
GO  GO:0030037;
GO  GO:0006888;
GO  GO:0043001;
GO  GO:0006890;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSDWKVDPDTRRRLLQLQKIGANKKCMDCGAPNPQWATPKFGAFICLECAGIHRGLGVHISFVRSITMDQFKPEELLRME
SQ  KGGNEPLTEWFKSHNIDLSLPQKVKYDNPVAEDYKEKLTCLCEDRVFEEREHLDFDASKLSATSQTAASATPGVAQSREG
SQ  TPLENRRSATPANSSNGANFQKEKNEAYFAELGKKNQSRPDHLPPSQGGKYQGFGSTPAKPPQERSAGSSNTLSLENFQA
SQ  DPLGTLSRGWGLFSSAVTKSFEDVNETVIKPHVQQWQSGELSEETKRAAAQFGQKFQETSSYGFQAFSNFTKNFNGNAED
SQ  SSTAGNTTHTEYQKIDNNDKKNEQDEDKWDDF
//