ID  P35368;
PN  Alpha-1B adrenergic receptor;
GN  ADRA1B;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:24567387}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:24567387}. Membrane, caveola {ECO:0000269|PubMed:24567387}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK- mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
DR  UNIPROT: P35368;
DR  UNIPROT: B0LPE1;
DR  Pfam: PF00001;
DR  PROSITE: PS00237;
DR  PROSITE: PS50262;
DR  OMIM: 104220;
DR  DisGeNET: 147;
DE  Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.
DE  Reference Proteome: Yes;
DE  Interaction: P35348; IntAct: EBI-21282743; Score: 0.40
DE  Interaction: Q14315; IntAct: EBI-490031; Score: 0.00
DE  Interaction: P02768; IntAct: EBI-1220884; Score: 0.35
DE  Interaction: P01857; IntAct: EBI-1222317; Score: 0.35
DE  Interaction: Q96SB3; IntAct: EBI-7385236; Score: 0.40
DE  Interaction: P21917; IntAct: EBI-15989057; Score: 0.47
DE  Interaction: P25106; IntAct: EBI-21283831; Score: 0.42
DE  Interaction: P61073; IntAct: EBI-21284190; Score: 0.61
DE  Interaction: P35368; IntAct: EBI-21282722; Score: 0.40
DE  Interaction: P25100; IntAct: EBI-21282754; Score: 0.40
GO  GO:0005901;
GO  GO:0005737;
GO  GO:0005887;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0005886;
GO  GO:0004937;
GO  GO:0004930;
GO  GO:0046982;
GO  GO:0071880;
GO  GO:0007188;
GO  GO:0007267;
GO  GO:0007186;
GO  GO:0035556;
GO  GO:0150099;
GO  GO:0007200;
GO  GO:0007204;
GO  GO:0001996;
GO  GO:0043410;
GO  GO:0045907;
GO  GO:0055117;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250};
SQ  MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPT
SQ  NYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRR
SQ  KAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
SQ  VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLF
SQ  STLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERS
SQ  QSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT
SQ  EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
//