ID  P35930;
PN  RNA-directed RNA polymerase;
GN  POL1;
OS  12262;
SL  Nucleus Position: SL-0382;
SL  Comments: [Putative helicase]: Host membrane {ECO:0000250|UniProtKB:P03600}; Single-pass membrane protein {ECO:0000250|UniProtKB:P03600}. Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:P03600}. [RNA-directed RNA polymerase]: Host endoplasmic reticulum {ECO:0000250|UniProtKB:P03600}. [Protease cofactor]: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:P03600}.
DR  UNIPROT: P35930;
DR  UNIPROT: Q66182;
DR  Pfam: PF00548;
DR  Pfam: PF00680;
DR  Pfam: PF00910;
DR  PROSITE: PS51874;
DR  PROSITE: PS50507;
DR  PROSITE: PS51218;
DE  Function: [Picornain 3C-like protease]: Thiol protease that cleaves the RNA1 and RNA2 polyproteins. {ECO:0000250|UniProtKB:P03600}. [Viral genome-linked protein]: Plays a role in RNA replication. It is covalently linked to the 5'terminus of both viral single-stranded RNA1 and RNA2 molecules. {ECO:0000250|UniProtKB:P03600}. [Protease cofactor]: Down-regulates the RNA1 polyprotein processing and enhances trans-cleavage of RNA2 polyproteins. The protease cofactor and the putative helicase seem to target the replication complexes to ER membranes. Their physical association causes the membrane rearrangement of host ER that may result in formation of the small membranous vesicles that are the site of viral RNA synthesis. {ECO:0000250|UniProtKB:P03600}. [Putative helicase]: The protease cofactor and the putative helicase seem to target the replication complexes to ER membranes. Their physical association causes the membrane rearrangement of host ER that may result in formation of the small membranous vesicles that are the site of viral RNA synthesis. {ECO:0000250|UniProtKB:P03600}. [RNA-directed RNA polymerase]: Replicates the viral genome. {ECO:0000250|UniProtKB:P03600}.
DE  Reference Proteome: No;
GO  GO:0044165;
GO  GO:0033644;
GO  GO:0044220;
GO  GO:0016021;
GO  GO:0005524;
GO  GO:0004197;
GO  GO:0003723;
GO  GO:0003724;
GO  GO:0003968;
GO  GO:0006351;
GO  GO:0006508;
GO  GO:0018144;
GO  GO:0039694;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MYMLTFEPGLCVAGIIRQVRSNPFMHVVQAYARTTETYREDIEMTKSMLKLKADEPLLVMSIVAAAMDFQTMVMAPIEME
SQ  ASEFLYGFYAERMSYIVTNRGMSELHEYIQLQCQRHLLVKVEIDGQYLVQEHEYEAQGFNIKRVKELITDVATWVPKKVK
SQ  GMIGWSVDAVLDSFQEYFYKVITERIPMAMKVCSWVATVWDQIKTWIEDAMTAMSSFLQGCNELLTWGLATLAACCALNV
SQ  LERILIFMEFLDESIDIAGIFLRTGVVAAACYHFSSTAKGFTEMMSVLSVATTAVAAVVCANYFGGSKTKKVNAQGNPVD
SQ  LLERIAAGLSSISQDSLVSLGKSCSAINSIATSYGHLRNFAGRVLTMLRDFAWKILGLETRFLADAALVFGEDVDGWLQR
SQ  ISALREAYVSKAYSSQDEVFEMNVLLERGYKMRHLMATGSRVSPAIGNMLMQGLADLERLHRNAAVQGVKGVRKIPFTVF
SQ  AHGNSRCGKSLLIGKLISDFQEHKGLGEDTVYSRNTTETHWSGYRRQPIVVIDDFAAVESDISAEAQLINLVSSTPYSVV
SQ  MAAIEEKGMTFDSQFIFASTNFLEVSPNGKIRCDDAFRNRRHVLIDVKLKPEVEYQSDDFTANQSYNILEHSHGRYNVVA
SQ  TFDNYEELLAYCLTKHEQHEAEQEANLAKLRRTNKFESHFKKFEQVLQLSTYFSSSIERIKREALATTDGADDYHLLYVV
SQ  PRNGSYLHVAANKDFQIQQWYGPVEEVAEEDILRASERMLLGAYEFLLLSTELNVVVKNHLPELICTDNYDHNLEFCGVV
SQ  GDPVYHQQLLKNIRALKPWHRAVLFGIGTLMGAKNPTPWYKRMWEGIKDVLYKAYSTEISQWPVPLKITCGIVLVGIVGA
SQ  GFWKTVSVLTNAGNGAGLVGAAVNSFSVVSTAEAQSRKPNRFEVQQYRYKNVPLTRRSWGNAQMSLDQSTVSILNKCHAK
SQ  FIIASQHAQIVLVPGRRFIGYSHFFCNLKHPLMVQIETADRTYFHRYQPENMEYIEDSELCVYHSSCLEDISHSCWDLFC
SQ  WDPDKELPKKFSADFVSCKYNTWTKSVEPTWANVDAEVIKEDFTICDGEYRNTVSTSIRYEAPTVMSDCGSMIITNVGGK
SQ  TKIVGIHVAGRDNKIGMASLLPPLLPCAQAQGAEKYFNFYPIEYDAAEGIARVGELKPKLYIPLPKKTSLVKTPEEWHLG
SQ  TPCDKVPSILVKGDPRLADTVHADYDPCLSGLTKYSTPMSPLDSVLLGETCQEILDEWFDCLPEGFELGEVTINEALNGV
SQ  DGVDYMDRIPLATSEGFPHVMSREQGEKGKQRFVQGDGHIVSLIPGTSVHEAYETLSRTIATEVPTLVGIECPKDEKLPF
SQ  RKVFTKPKTRNFTILPMEYNILVRQYFLNFVRFIMKKRDVLPCQVGINPYSMEWSIVASRLKSQGNDILCCDYSSFDGLL
SQ  SKQIMEMMADMINRFCGGGTLICAKRKNLLMACCSRLAISRDSVWRIECGIPSGFPLTVICNSIFNEILVRYHYKLLLQE
SQ  HNAPNMYVQSFKNLISMVTYGDDNLISVNAVVKPYFDGTKLKQAMARNGIIITDGKDKTSATLEFRRLEDCDFLKRGFLK
SQ  RSSVLWDAPEEKASLWAQLHYVNVNNCEMQVAYMTNLVNVLRELYMHDPTEMVEFRRLALKSIPWLNTTDLPTLYQVKEF
SQ  YAEQRLRNIPDHNDSLDMLTSVDLLGPAILGEGVPQEALVLSELLEVRDLRYHTVPDNDNGKEVWILFNTMYPQKLLPSN
SQ  CHSFTWNCGQGRGGLPTQHWLATNVTRTDSKLNKLIRTAVAANKKIVLATKDNILPINVIAVLLAARNKVMPSLATNALL
SQ  TYVIGAAKKLNFLTSECQFAFFNV
//