ID  P36161;
PN  Nucleoporin NUP133;
GN  NUP133;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
DR  UNIPROT: P36161;
DR  UNIPROT: D6VXE2;
DR  PDB: 3KFO;
DR  PDB: 6X02;
DR  PDB: 6X03;
DR  PDB: 6X04;
DR  PDB: 6X05;
DR  PDB: 7N84;
DR  PDB: 7N9F;
DR  Pfam: PF08801;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP133 is involved in nuclear poly(A)+ RNA, tRNA and pre- ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization. {ECO:0000269|PubMed:10684247, ECO:0000269|PubMed:11071906, ECO:0000269|PubMed:11823431, ECO:0000269|PubMed:12730220, ECO:0000269|PubMed:7813444, ECO:0000269|PubMed:7862658, ECO:0000269|PubMed:8524308, ECO:0000269|PubMed:9049242}.
DE  Reference Proteome: Yes;
DE  Interaction: P14907; IntAct: EBI-7438937; Score: 0.44
DE  Interaction: P35729; IntAct: EBI-15786270; Score: 0.75
DE  Interaction: P46673; IntAct: EBI-295762; Score: 0.55
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.32
DE  Interaction: P16140; IntAct: EBI-787098; Score: 0.35
DE  Interaction: P0CS90; IntAct: EBI-787098; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-787098; Score: 0.35
DE  Interaction: P22515; IntAct: EBI-7101777; Score: 0.40
DE  Interaction: Q06440; IntAct: EBI-7438922; Score: 0.40
DE  Interaction: P40477; IntAct: EBI-7439043; Score: 0.40
DE  Interaction: P40368; IntAct: EBI-8466646; Score: 0.40
DE  Interaction: Q02647; IntAct: EBI-8466751; Score: 0.40
DE  Interaction: P52891; IntAct: EBI-7700705; Score: 0.55
DE  Interaction: Q04439; IntAct: EBI-7454093; Score: 0.37
DE  Interaction: P22696; IntAct: EBI-2883245; Score: 0.00
DE  Interaction: Q04477; IntAct: EBI-2887856; Score: 0.00
DE  Interaction: P11484; IntAct: EBI-3691902; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-3712954; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3727430; Score: 0.35
DE  Interaction: P15108; IntAct: EBI-3734627; Score: 0.35
DE  Interaction: P33416; IntAct: EBI-3745787; Score: 0.35
DE  Interaction: Q12329; IntAct: EBI-3750959; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3799837; Score: 0.35
DE  Interaction: P02829; IntAct: EBI-3812927; Score: 0.35
DE  Interaction: P48363; IntAct: EBI-3817414; Score: 0.35
DE  Interaction: P47079; IntAct: EBI-3823897; Score: 0.35
DE  Interaction: P31539; IntAct: EBI-3827376; Score: 0.35
DE  Interaction: Q04432; IntAct: EBI-3830694; Score: 0.35
DE  Interaction: P38181; IntAct: EBI-4392409; Score: 0.37
DE  Interaction: P39523; IntAct: EBI-9976090; Score: 0.35
DE  Interaction: Q04491; IntAct: EBI-16281671; Score: 0.35
GO  GO:0000781;
GO  GO:0005829;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0031080;
GO  GO:0005634;
GO  GO:0017056;
GO  GO:0006302;
GO  GO:0031990;
GO  GO:0000122;
GO  GO:0051664;
GO  GO:0006913;
GO  GO:0016973;
GO  GO:0045893;
GO  GO:0045944;
GO  GO:0000973;
GO  GO:0006606;
GO  GO:0030466;
GO  GO:0031509;
GO  GO:0034398;
GO  GO:0000972;
GO  GO:0006409;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MSEKKVHLRLRKELSVPIAVVENESLAQLSYEEESQASLMDISMEQQQLRLHSHFDNSKVFTENNRYIVKTLQTDYSSGF
SQ  SNDDELNGYIDMQIGYGLVNDHKKVYIWNIHSTQKDTPYITVPFRSDDNDEIAVAPRCILTFPATMDESPLALNPNDQDE
SQ  TGGLIIIKGSKAIYYEDINSINNLNFKLSEKFSHELELPINSSGGEKCDLMLNCEPAGIVLSTNMGRIFFITIRNSMGKP
SQ  QLKLGKLLNKPFKLGIWSKIFNTNSSVVSLRNGPILGKGTRLVYITTNKGIFQTWQLSATNSHPTKLIDVNIYEAILESL
SQ  QDLYPFAHGTLKIWDSHPLQDESSQLFLSSIYDSSCNETYYILSTIIFDSSSNSFTIFSTYRLNTFMESITDTKFKPKIF
SQ  IPQMENANDTNEVTSILVMFPNAVVITQVNSKLDSSYSMRRKWEDIVSLRNDIDIIGSGYDSKSLYVLTKQMGVLQFFVK
SQ  ENEETNSKPEVGFVKSHVDQAVYFSKINANPIDFNLPPEISLDQESIEHDLKLTSEEIFHSNGKYIPPMLNTLGQHLSVR
SQ  KEFFQNFLTFVAKNFNYKISPELKLDLIEKFEILNCCIKFNSIIRQSDVLNDIWEKTLSNYNLTQNEHLTTKTVVINSPD
SQ  VFPVIFKQFLNHVVFVLFPSQNQNFKLNVTNLINLCFYDGILEEGEKTIRYELLELDPMEVDTSKLPWFINFDYLNCINQ
SQ  CFFDFTFACEEEGSLDSYKEGLLKIVKILYYQFNQFKIWINTQPVKSVNANDNFININNLYDDNHLDWNHVLCKVNLKEQ
SQ  CIQIAEFYKDLSGLVQTLQTLDQNDSTTVSLYETFFNEFPKEFSFTLFEYLIKHKKLNDLIFRFPQQHDVLIQFFQESAP
SQ  KYGHVAWIQQILDGSYADAMNTLKNITVDDSKKGESLSECELHLNVAKLSSLLVEKDNLDINTLRKIQYNLDTIDAEKNI
SQ  SNKLKKGEVQICKRFKNGSIREVFNILVEELKSTTVVNLSDLVELYSMLDDEESLFIPLRLLSVDGNLLNFEVKKFLNAL
SQ  VWRRIVLLNASNEGDKLLQHIVKRVFDEELPKNNDFPLPSVDLLCDKSLLTPEYISETYGRFPIDQNAIREEIYEEISQV
SQ  ETLNSDNSLEIKLHSTIGSVAKEKNYTINYETNTVEY
//