ID  P38181;
PN  Nucleoporin NUP170;
GN  NUP170;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution. {ECO:0000269|PubMed:10684247}.
DR  UNIPROT: P38181;
DR  UNIPROT: D6VPS4;
DR  PDB: 3I5P;
DR  PDB: 3I5Q;
DR  PDB: 7N85;
DR  PDB: 7N9F;
DR  PDB: 7WOO;
DR  PDB: 7WOT;
DR  Pfam: PF03177;
DR  Pfam: PF08801;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity. {ECO:0000269|PubMed:10684247, ECO:0000269|PubMed:11290711, ECO:0000269|PubMed:12403813, ECO:0000269|PubMed:12473689, ECO:0000269|PubMed:14697200, ECO:0000269|PubMed:9864357}.
DE  Reference Proteome: Yes;
DE  Interaction: P25491; IntAct: EBI-3765464; Score: 0.35
DE  Interaction: P32499; IntAct: EBI-1270066; Score: 0.00
DE  Interaction: P36161; IntAct: EBI-4392409; Score: 0.37
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.32
DE  Interaction: Q03790; IntAct: EBI-805269; Score: 0.72
DE  Interaction: Q06440; IntAct: EBI-7439664; Score: 0.40
DE  Interaction: P31787; IntAct: EBI-7895309; Score: 0.44
DE  Interaction: P53141; IntAct: EBI-8467427; Score: 0.40
DE  Interaction: Q02630; IntAct: EBI-1269692; Score: 0.00
DE  Interaction: Q02629; IntAct: EBI-1269835; Score: 0.00
DE  Interaction: P48837; IntAct: EBI-1269978; Score: 0.00
DE  Interaction: P53233; IntAct: EBI-2611781; Score: 0.35
DE  Interaction: P23291; IntAct: EBI-2614250; Score: 0.35
DE  Interaction: P29366; IntAct: EBI-7311861; Score: 0.31
DE  Interaction: Q00684; IntAct: EBI-2882792; Score: 0.00
DE  Interaction: P14832; IntAct: EBI-2882919; Score: 0.00
DE  Interaction: P22696; IntAct: EBI-2883245; Score: 0.00
DE  Interaction: Q04477; IntAct: EBI-2887856; Score: 0.00
DE  Interaction: P40358; IntAct: EBI-3657508; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3772658; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3781749; Score: 0.35
DE  Interaction: P38181; IntAct: EBI-4325351; Score: 0.37
DE  Interaction: P40064; IntAct: EBI-4325343; Score: 0.37
DE  Interaction: P49687; IntAct: EBI-4421662; Score: 0.59
DE  Interaction: P32597; IntAct: EBI-6879758; Score: 0.50
DE  Interaction: P11938; IntAct: EBI-6879805; Score: 0.35
DE  Interaction: P11978; IntAct: EBI-6879786; Score: 0.50
DE  Interaction: P39929; IntAct: EBI-10052681; Score: 0.44
DE  Interaction: Q03281; IntAct: EBI-10052697; Score: 0.44
DE  Interaction: Q03707; IntAct: EBI-10052689; Score: 0.37
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044611;
GO  GO:0003682;
GO  GO:1990841;
GO  GO:0044877;
GO  GO:0017056;
GO  GO:0007059;
GO  GO:0031507;
GO  GO:0051028;
GO  GO:0051292;
GO  GO:0006913;
GO  GO:0006606;
GO  GO:0036228;
GO  GO:0006405;
GO  GO:0034398;
GO  GO:0000972;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MFQSFFHNNGPAAAGETFSDSRSYPLTNHQEVPRNGLNELASSATKAQQQPTHILNSYPITGSNPLMRASAMGATSGSIN
SQ  PNMSNMNEHIRVSGMGTSKPLDLAGKYIDHLQHKDSNTPVLDERSYYNSGVDYNFSREKNGLGAFTPFEKQDVFNIPDEI
SQ  LHEFSTSQTKTDMGIFPELNRCWITIDNKLILWNINNDNEYQVVDDMKHTIQKVALVRPKPNTFVPAVKHLLLISTTMEL
SQ  FMFAISLDKATNELSVFNTHLSVPVQGIDVIDIVSHERSGRIFFAGQASGLNIWELHYSGSDDWFNSKCSKVCLTKSALL
SQ  SLLPTNMLSQIPGVDFIQALFEDNSNGNGGFSQETITQLTIDQQRGIIYSLSSKSTIRAYVITEKSLEGPMSIEPAYISR
SQ  IIGTTTARAAPILGPKYLKIVKISSVAPEENNNLFLVALTVGGVRLYFNGSMGRFNIEALRLESIKFPPSSVTPEVIQQE
SQ  LLHQQQEQAKRSFPFFSNLMSSEPVLLKFQKKSSVLLETTKASTIISPGIFFSAVIKSSQQTHQQEKKENSSVTGTTATA
SQ  GSKTVKQQPVTLQHKLFVSVPDYGILKTHGKYVENATFLETAGPVQQIIPLSGLFNATTKPQGFANEFATQYTSETLRVA
SQ  VLTSTSIEIYKYRTPDEIFEDLIDNPLPFVLNYGAAEACSTALFVTCKSNKSEKLRSNALTFLTMGIPGVVDIKPVYNRY
SQ  SVSTVSSLLSKPTLSTATTNLQQSITGFSKPSPANKEDFDLDDVILSPRFYGIALLITRLLRDIWGRHVFMTFTDNRVTS
SQ  HAFISSSDPITPSINNLKSDEISQNRNIISKVSISKDCIEYYLSSINILNEFFITYGDSISQISAPYVLANNSNGRVIDK
SQ  TEEVANQAESIAINAMIKMVQSIKEGLSFLNVLYEESEVEGFDNQYLGFKDIISFVSLDVQKDLVKLDFKDLFAPNDKTK
SQ  SLIREILLSIINRNITKGASIEYTATALQERCGSFCSASDILGFRAIEHLRRAKEIGLRNYDSLNYHLKNATALLEQIVD
SQ  DLSIEKLKEAVSMMLSVNYYPKSIEFLLNIANSMDKGKLACQYVANGFLENDDRKQYYDKRILVYDLVFDTLIKVDELAE
SQ  KKQSSKTQNQISISNDDEVKLRQKSYEAALKYNDRLFHYHMYDWLVSQNREEKLLDIETPFILPYLMEKAGSSLKISNIL
SQ  WVYYSRRSKFFESAEILYRLATSNFDITLFERIEFLSRANGFCNSVSPLSQKQRIVQLASRIQDACEVAGIQGDILSLVY
SQ  TDARIDSAIKDELIKTLDGKILSTSELFNDFAVPLSYHEIALFIFKIADFRDHEVIMAKWDELFQSLRMEFNNTGKKEDS
SQ  MNFINLLSNVLIKIGKNVQDSEFIFPIFELFPIVCNFFYETLPKEHIVSGSIVSIFITAGVSFNKMYYILKELIETSDSD
SQ  NSVFNKEMTWLIHEWYKSDRKFRDIISYNDIIHLKEYKIDNDPIEKYVKNSGNNLGICFYKE
//