ID  P38757;
PN  Nuclear envelope morphology protein 1;
GN  NEM1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9822591}; Single-pass membrane protein {ECO:0000269|PubMed:9822591}. Nucleus membrane {ECO:0000269|PubMed:9822591}; Single-pass membrane protein {ECO:0000269|PubMed:9822591}.
DR  UNIPROT: P38757;
DR  UNIPROT: D3DKU7;
DR  Pfam: PF03031;
DR  PROSITE: PS50969;
DE  Function: Catalytic component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates the phosphatidic acid phosphohydrolase PAH1 (PubMed:15889145). Essential for the formation of a spherical nucleus and meiotic division (PubMed:9822591). The NEM1-SPOo7 protein phosphatase is required for efficient mitophagy under prolonged respiration, as well as for reticulophagy and pexophagy (PubMed:29305265). {ECO:0000269|PubMed:15889145, ECO:0000269|PubMed:29305265, ECO:0000269|PubMed:9822591}.
DE  Reference Proteome: Yes;
DE  Interaction: P18410; IntAct: EBI-787710; Score: 0.56
DE  Interaction: P40018; IntAct: EBI-6331360; Score: 0.00
DE  Interaction: P38074; IntAct: EBI-8764817; Score: 0.37
DE  Interaction: P13712; IntAct: EBI-16251536; Score: 0.00
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0005811;
GO  GO:0005739;
GO  GO:0071595;
GO  GO:0031965;
GO  GO:0017018;
GO  GO:0004722;
GO  GO:0140042;
GO  GO:0071072;
GO  GO:0006998;
GO  GO:0046889;
GO  GO:1903740;
GO  GO:0008104;
GO  GO:0071071;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MNALKYFSNHLITTKKQKKINVEVTKNQDLLGPSKEVSNKYTSHSENDCVSEVDQQYDHSSSHLKESDQNQERKNSVPKK
SQ  PKALRSILIEKIASILWALLLFLPYYLIIKPLMSLWFVFTFPLSVIERRVKHTDKRNRGSNASENELPVSSSNINDSSEK
SQ  TNPKNCNLNTIPEAVEDDLNASDEIILQRDNVKGSLLRAQSVKSRPRSYSKSELSLSNHSSSNTVFGTKRMGRFLFPKKL
SQ  IPKSVLNTQKKKKLVIDLDETLIHSASRSTTHSNSSQGHLVEVKFGLSGIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTA
SQ  SMKEYADPVIDWLESSFPSSFSKRYYRSDCVLRDGVGYIKDLSIVKDSEENGKGSSSSLDDVIIIDNSPVSYAMNVDNAI
SQ  QVEGWISDPTDTDLLNLLPFLEAMRYSTDVRNILALKHGEKAFNIN
//