ID  P38937;
PN  Tethering factor for nuclear proteasome cut8;
GN  cut8;
OS  284812;
SL  Nucleus Position: SL-0178;
SL  Comments: Nucleus envelope {ECO:0000269|PubMed:11084332, ECO:0000269|PubMed:28974540}.
DR  UNIPROT: P38937;
DR  PDB: 3Q5W;
DR  PDB: 3Q5X;
DR  Pfam: PF08559;
DE  Function: Together with nucleoporin alm1, tethers the proteasome to the nuclear envelope (PubMed:28974540, PubMed:11084332, PubMed:16096059). Involved in ubiquitin-mediated protein degradation and facilitates the degradation of nuclear proteins like mitotic cyclin and cut2 (PubMed:11084332, PubMed:16096059). Required for normal progression of anaphase (PubMed:8065367, PubMed:11084332). {ECO:0000269|PubMed:11084332, ECO:0000269|PubMed:16096059, ECO:0000269|PubMed:28974540, ECO:0000269|PubMed:8065367}.
DE  Reference Proteome: Yes;
DE  Interaction: P50524; IntAct: EBI-1152618; Score: 0.52
DE  Interaction: P41878; IntAct: EBI-1152637; Score: 0.40
DE  Interaction: P87048; IntAct: EBI-1152745; Score: 0.54
DE  Interaction: P40303; IntAct: EBI-1152891; Score: 0.40
DE  Interaction: P23566; IntAct: EBI-1153015; Score: 0.43
DE  Interaction: P38937; IntAct: EBI-15946480; Score: 0.62
GO  GO:0000785;
GO  GO:0005635;
GO  GO:0034399;
GO  GO:0005634;
GO  GO:0042802;
GO  GO:0032934;
GO  GO:0034080;
GO  GO:0071630;
GO  GO:0031144;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  METLSYSQIKKRKADFDEDISKRARQLPVGEQLPLSRLLQYSDKQQLFTILLQCVEKHPDLARDIRGILPAPSMDTCVET
SQ  LRKLLINLNDSFPYGGDKRGDYAFNRIREKYMAVLHALNDMVPCYLPPYSTCFEKNITFLDAATNVVHELPEFHNPNHNV
SQ  YKSQAYYELTGAWLVVLRQLEDRPVVPLLPLEELEEHNKTSQNRMEEALNYLKQLQKNEPLVHERSHTFQQTNPQNNFHR
SQ  HTNSMNIGNDNGMGWHSMHQYI
//