ID  P39705;
PN  Nucleoporin NUP60;
GN  NUP60;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Nuclear basket.
DR  UNIPROT: P39705;
DR  UNIPROT: D6VPL6;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). {ECO:0000269|PubMed:10684247, ECO:0000269|PubMed:11387327, ECO:0000269|PubMed:11535617, ECO:0000269|PubMed:12604785, ECO:0000269|PubMed:15039779}.
DE  Reference Proteome: Yes;
DE  Interaction: P25491; IntAct: EBI-3663903; Score: 0.35
DE  Interaction: P32499; IntAct: EBI-801825; Score: 0.70
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.32
DE  Interaction: Q02821; IntAct: EBI-802293; Score: 0.69
DE  Interaction: Q06142; IntAct: EBI-802293; Score: 0.77
DE  Interaction: P40069; IntAct: EBI-810484; Score: 0.67
DE  Interaction: P28003; IntAct: EBI-815383; Score: 0.27
DE  Interaction: Q12449; IntAct: EBI-818622; Score: 0.27
DE  Interaction: P40433; IntAct: EBI-7452404; Score: 0.35
DE  Interaction: P34232; IntAct: EBI-2124365; Score: 0.40
DE  Interaction: Q99257; IntAct: EBI-2124365; Score: 0.40
DE  Interaction: P11710; IntAct: EBI-7313261; Score: 0.31
DE  Interaction: P40358; IntAct: EBI-3657524; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3673786; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3691934; Score: 0.35
DE  Interaction: P36016; IntAct: EBI-3707787; Score: 0.35
DE  Interaction: P10592; IntAct: EBI-3712986; Score: 0.35
DE  Interaction: P33416; IntAct: EBI-3825819; Score: 0.35
DE  Interaction: Q02336; IntAct: EBI-4379269; Score: 0.35
DE  Interaction: P50102; IntAct: EBI-4380099; Score: 0.35
DE  Interaction: Q01560; IntAct: EBI-7082733; Score: 0.40
GO  GO:0005829;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044613;
GO  GO:0044615;
GO  GO:0005634;
GO  GO:0005543;
GO  GO:0017056;
GO  GO:0051276;
GO  GO:0006302;
GO  GO:0008298;
GO  GO:0031990;
GO  GO:0006607;
GO  GO:0006913;
GO  GO:0016973;
GO  GO:0000973;
GO  GO:0006611;
GO  GO:0060188;
GO  GO:0030466;
GO  GO:0034398;
GO  GO:0000972;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MHRKSLRRASATVPSAPYRKQIISNAHNKPSLFSKIKTFFTQKDSARVSPRNNVANKQPRNESFNRRISSMPGGYFHSEI
SQ  SPDSTVNRSVVVSAVGEARNDIENKEEEYDETHETNISNAKLANFFSKKGNEPLSEIEIEGVMSLLQKSSKSMITSEGEQ
SQ  KSAEGNNIDQSLILKESGSTPISISNAPTFNPKYDTSNASMNTTLGSIGSRKYSFNYSSLPSPYKTTVYRYSAAKKIPDT
SQ  YTANTSAQSIASAKSVRSGVSKSAPSKKISNTAAALVSLLDENDSKKNNAASELANPYSSYVSQIRKHKRVSPNAAPRQE
SQ  ISEEETTVKPLFQNVPEQGEEPMKQLNATKISPSAPSKDSFTKYKPARSSSLRSNVVVAETSPEKKDGGDKPPSSAFNFS
SQ  FNTSRNVEPTENAYKSENAPSASSKEFNFTNLQAKPLVGKPKTELTKGDSTPVQPDLSVTPQKSSSKGFVFNSVQKKSRS
SQ  NLSQENDNEGKHISASIDNDFSEEKAEEFDFNVPVVSKQLGNGLVDENKVEAFKSLYTF
//