ID  P40064;
PN  Nucleoporin NUP157;
GN  NUP157;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
DR  UNIPROT: P40064;
DR  UNIPROT: D3DM12;
DR  PDB: 4MHC;
DR  PDB: 7N85;
DR  PDB: 7N9F;
DR  PDB: 7WOO;
DR  PDB: 7WOT;
DR  Pfam: PF03177;
DR  Pfam: PF08801;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. {ECO:0000269|PubMed:10684247, ECO:0000269|PubMed:12473689}.
DE  Reference Proteome: Yes;
DE  Interaction: P25491; IntAct: EBI-3765456; Score: 0.35
DE  Interaction: P38181; IntAct: EBI-4325343; Score: 0.37
DE  Interaction: P30657; IntAct: EBI-698282; Score: 0.37
DE  Interaction: P23724; IntAct: EBI-698381; Score: 0.37
DE  Interaction: P40958; IntAct: EBI-390855; Score: 0.37
DE  Interaction: Q03790; IntAct: EBI-390858; Score: 0.55
DE  Interaction: P39998; IntAct: EBI-390861; Score: 0.37
DE  Interaction: P30283; IntAct: EBI-393078; Score: 0.37
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.32
DE  Interaction: P39081; IntAct: EBI-858214; Score: 0.00
DE  Interaction: P47007; IntAct: EBI-861577; Score: 0.00
DE  Interaction: Q08817; IntAct: EBI-861604; Score: 0.00
DE  Interaction: P40477; IntAct: EBI-6332396; Score: 0.00
DE  Interaction: Q02629; IntAct: EBI-6340320; Score: 0.00
DE  Interaction: P53739; IntAct: EBI-2611855; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3673746; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-3781733; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3806428; Score: 0.35
DE  Interaction: P02829; IntAct: EBI-3812935; Score: 0.35
DE  Interaction: P11978; IntAct: EBI-6879814; Score: 0.40
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044611;
GO  GO:0003677;
GO  GO:0003723;
GO  GO:0017056;
GO  GO:0051028;
GO  GO:0051292;
GO  GO:0006913;
GO  GO:0000973;
GO  GO:0006606;
GO  GO:0036228;
GO  GO:0006405;
GO  GO:0000972;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MYSTPLKKRIDYDRETFTASASLGGNRLRNRPRDDQNNGKPNLSSRSFLSERKTRKDVLNKYGEAGNTIESELRDVTTHV
SQ  KISGLTSSEPLQLASEFVQDLSFRDRNTPILDNPDYYSKGLDYNFSDEVGGLGAFTPFQRQQVTNIPDEVLSQVSNTEIK
SQ  SDMGIFLELNYCWITSDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYILTISFNDR
SQ  THELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDGVNVWELQYNCSENLFNSKSNKICLTKSNLANLLPTKLIPS
SQ  IPGGKLIQKVLEGDAGTEEETISQLEVDQSRGVLHTLSTKSIVRSYLITSNGLVGPVLIDAAHIRRGMNALGVKNSPLLS
SQ  NRAFKIAKIVSISMCENNDLFLAVITTTGVRLYFKGSISRRSIGSLKLDSVKFPPTSISSSLEQNKSFIIGHHPLNTHDT
SQ  GPLSTQKASSTYINTTCASTIISPGIYFTCVRKRANSGELSKGITNKALLENKEEHKLYVSAPDYGILKNYGKYVENTAL
SQ  LDTTDEIKEIVPLTRSFNYTSTPQGYANVFASQYSAEPLKVAVLTSNALEIYCYRTPDEVFESLIENPLPFIHSYGLSEA
SQ  CSTALYLACKFNKSEHIKSSALAFFSAGIPGVVEIKPKSSRESGSVPPISQNLFDKSGECDGIVLSPRFYGSALLITRLF
SQ  SQIWEERVFVFKRASKTEKMDAFGISITRPQVEYYLSSISVLADFFNIHRPSFVSFVPPKGSNAITASDAESIAMNALIL
SQ  LINSIKDALSLINVFYEDIDAFKSLLNTLMGAGGVYDSKTREYFFDLKFHDLFTPNAKTKQLIKEILIEVVNANIASGTS
SQ  ADYIVNVLKERFGSFCHSADILCYRAGEHLEAAQKFEMIDSKISRNHLDTAIDLYERCAENIELCELRRVVDIMVKLNYQ
SQ  PKTVGFLLRFADKIDKGNQAQEYVSRGCNTADPRKVFYDKRINVYTLIFEIVKSVDDYTSIEQSPSIANISIFSPASSLK
SQ  KRVYSVIMNSNNRFFHYCFYDWLVANKRQDYLLRLDSQFVLPYLKERAEKSLEISNLLWFYLFKEEHFLEAADVLYALAS
SQ  SDFDLKLSERIECLARANGLCDSSTSFDQKPALVQLSENIHELFDIASIQDDLLNLVRNETRIDEDYRKQLTLKLNGRVL
SQ  PLSDLFNDCADPLDYYEIKLRIFKVSQFKDEKVIQGEWNRLLDSMKNAPSPDVGSVGQESFLSSISNTLIRIGKTTRDTD
SQ  VVFPVHFLMNKILESFIDKSSAADGSVCSMFLLAGVSHLKLYYILSRIIENSEGNVELAKKEMVWLIKDWYQSDSDLRGS
SQ  IAPEQIKKLEKYDPNTDPVQDYVKDRHHGLK
//