ID  P40075;
PN  Vesicle-associated membrane protein-associated protein SCS2;
GN  SCS2;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Nucleus membrane; Single-pass type IV membrane protein.
DR  UNIPROT: P40075;
DR  UNIPROT: D3DM26;
DR  PDB: 6LP4;
DR  Pfam: PF00635;
DR  PROSITE: PS50202;
DE  Function: Targets proteins containing a FFAT motif to endoplasmic reticulum membranes. Regulates phospholipid biosynthesis by modulating the subcellular localization of the transcriptional repressor OPI1. {ECO:0000269|PubMed:12727870, ECO:0000269|PubMed:15668246}.
DE  Reference Proteome: Yes;
DE  Interaction: P25491; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P35845; IntAct: EBI-803541; Score: 0.55
DE  Interaction: P40069; IntAct: EBI-7043141; Score: 0.35
DE  Interaction: P53968; IntAct: EBI-393147; Score: 0.37
DE  Interaction: P17064; IntAct: EBI-7774593; Score: 0.37
DE  Interaction: P21957; IntAct: EBI-788157; Score: 0.59
DE  Interaction: P16140; IntAct: EBI-803541; Score: 0.53
DE  Interaction: P37297; IntAct: EBI-803541; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-803541; Score: 0.53
DE  Interaction: P10592; IntAct: EBI-803541; Score: 0.53
DE  Interaction: P10591; IntAct: EBI-803541; Score: 0.53
DE  Interaction: P38886; IntAct: EBI-803541; Score: 0.35
DE  Interaction: P49626; IntAct: EBI-803541; Score: 0.35
DE  Interaction: P53252; IntAct: EBI-803541; Score: 0.53
DE  Interaction: Q12451; IntAct: EBI-803541; Score: 0.55
DE  Interaction: Q00402; IntAct: EBI-803541; Score: 0.69
DE  Interaction: P38631; IntAct: EBI-803541; Score: 0.35
DE  Interaction: P12385; IntAct: EBI-813651; Score: 0.27
DE  Interaction: P47088; IntAct: EBI-856798; Score: 0.00
DE  Interaction: P40509; IntAct: EBI-7677816; Score: 0.40
DE  Interaction: P53622; IntAct: EBI-8225904; Score: 0.22
DE  Interaction: Q03656; IntAct: EBI-2613750; Score: 0.35
DE  Interaction: P38713; IntAct: EBI-3843675; Score: 0.57
DE  Interaction: P39523; IntAct: EBI-9977109; Score: 0.62
DE  Interaction: Q07657; IntAct: EBI-9977134; Score: 0.63
DE  Interaction: P34216; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P25694; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P34760; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P32610; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P00549; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P00358; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: Q12230; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P15108; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: Q06385; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P19882; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: Q12377; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P00925; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P00359; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P60010; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P21672; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: Q08229; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P41940; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P07149; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P00330; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P18759; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P22137; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P38616; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P00950; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: Q03661; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P19097; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P28834; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P02557; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P47079; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P41277; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P28241; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P07259; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: P22203; IntAct: EBI-9975925; Score: 0.35
DE  Interaction: O15209; IntAct: EBI-11530372; Score: 0.56
DE  Interaction: Q08984; IntAct: EBI-12425154; Score: 0.37
DE  Interaction: Q04660; IntAct: EBI-16268743; Score: 0.35
DE  Interaction: P38882; IntAct: EBI-16289509; Score: 0.35
GO  GO:0005935;
GO  GO:0005934;
GO  GO:0000781;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0030176;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0071561;
GO  GO:0005886;
GO  GO:0033149;
GO  GO:0035091;
GO  GO:0048309;
GO  GO:0090158;
GO  GO:0061163;
GO  GO:0061817;
GO  GO:0042308;
GO  GO:0008654;
GO  GO:0032377;
GO  GO:0060304;
GO  GO:0031509;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MSAVEISPDVLVYKSPLTEQSTEYASISNNSDQTIAFKVKTTAPKFYCVRPNAAVVAPGETIQVQVIFLGLTEEPAADFK
SQ  CRDKFLVITLPSPYDLNGKAVADVWSDLEAEFKQQAISKKIKVKYLISPDVHPAQNQNIQENKETVEPVVQDSEPKEVPA
SQ  VVNEKEVPAEPETQPPVQVKKEEVPPVVQKTVPHENEKQTSNSTPAPQNQIKEAATVPAENESSSMGIFILVALLILVLG
SQ  WFYR
//