ID  P40305;
PN  Interferon alpha-inducible protein 27, mitochondrial;
GN  IFI27;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Mitochondrion membrane {ECO:0000269|PubMed:18330707, ECO:0000269|PubMed:27673746}; Multi-pass membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000269|PubMed:11722583, ECO:0000269|PubMed:22427340}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22427340}; Multi-pass membrane protein {ECO:0000255}. Note=Exclusive localizations in either the nucleus or the mitochondrion have been reported. {ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:27673746}.
DR  UNIPROT: P40305;
DR  UNIPROT: A0A087WZF8;
DR  UNIPROT: A8K0H0;
DR  UNIPROT: Q53YA6;
DR  UNIPROT: Q6IEC1;
DR  UNIPROT: Q7Z5R0;
DR  UNIPROT: Q7Z5R1;
DR  UNIPROT: Q7Z5R2;
DR  UNIPROT: Q96BK3;
DR  UNIPROT: Q9H4B1;
DR  Pfam: PF06140;
DR  OMIM: 600009;
DR  DisGeNET: 3429;
DE  Function: Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin- mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077). {ECO:0000250|UniProtKB:Q8R412, ECO:0000269|PubMed:18330707, ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:24970806, ECO:0000269|PubMed:27194766, ECO:0000269|PubMed:27673746, ECO:0000269|PubMed:27777077}.
DE  Reference Proteome: Yes;
DE  Interaction: P02545; IntAct: EBI-27124576; Score: 0.40
DE  Interaction: Q5NGF6; IntAct: EBI-2805959; Score: 0.00
DE  Interaction: Q81KT8; IntAct: EBI-2831742; Score: 0.00
DE  Interaction: A0A6H3ABE4; IntAct: EBI-2831749; Score: 0.00
DE  Interaction: A0A6L7HHX2; IntAct: EBI-2831761; Score: 0.00
DE  Interaction: A0A6L7HB40; IntAct: EBI-2831768; Score: 0.00
DE  Interaction: Q8ZCW0; IntAct: EBI-2847220; Score: 0.00
DE  Interaction: A0A5P8YAW1; IntAct: EBI-2867067; Score: 0.00
DE  Interaction: A0A380PNP6; IntAct: EBI-2867060; Score: 0.00
DE  Interaction: P17778; IntAct: EBI-2867046; Score: 0.00
DE  Interaction: A0A3N4BEU0; IntAct: EBI-2867053; Score: 0.00
DE  Interaction: Q8ZG09; IntAct: EBI-2867074; Score: 0.00
DE  Interaction: Q8ZHF1; IntAct: EBI-2867081; Score: 0.00
DE  Interaction: P05549; IntAct: EBI-9679979; Score: 0.37
DE  Interaction: Q92754; IntAct: EBI-9680053; Score: 0.37
DE  Interaction: P55056; IntAct: EBI-24754759; Score: 0.56
DE  Interaction: P22736; IntAct: EBI-27124261; Score: 0.61
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0031966;
GO  GO:0005741;
GO  GO:0005739;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0042802;
GO  GO:0005521;
GO  GO:0061629;
GO  GO:0006915;
GO  GO:0097190;
GO  GO:0051607;
GO  GO:0097191;
GO  GO:0045087;
GO  GO:0044827;
GO  GO:0000122;
GO  GO:0043161;
GO  GO:0070936;
GO  GO:0046825;
GO  GO:0060337;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MEASALTSSAVTSVAKVVRVASGSAVVLPLARIATVVIGGVVAMAAVPMVLSAMGFTAAGIASSSIAAKMMSAAAIANGG
SQ  GVASGSLVATLQSLGATGLSGLTKFILGSIGSAIAAVIARFY
//