ID  P40477;
PN  Nucleoporin NUP159;
GN  NUP159;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10684247, ECO:0000269|PubMed:17546040, ECO:0000269|PubMed:23223634, ECO:0000269|PubMed:25646085}. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side.
DR  UNIPROT: P40477;
DR  UNIPROT: D6VVH2;
DR  PDB: 1XIP;
DR  PDB: 3PBP;
DR  PDB: 3RRM;
DR  PDB: 3TKN;
DR  PDB: 4DS1;
DR  PDB: 7N9F;
DR  Pfam: PF16755;
DE  Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP159 plays an important role in several nuclear export pathways including poly(A)+ RNA, pre- ribosome, and protein export. {ECO:0000269|PubMed:10523319, ECO:0000269|PubMed:10801828, ECO:0000269|PubMed:10952996, ECO:0000269|PubMed:11387327, ECO:0000269|PubMed:11689687, ECO:0000269|PubMed:11739405, ECO:0000269|PubMed:12543930, ECO:0000269|PubMed:12604785, ECO:0000269|PubMed:15039779, ECO:0000269|PubMed:15574330, ECO:0000269|PubMed:9736720, ECO:0000269|PubMed:9843582, ECO:0000269|PubMed:9891088}.
DE  Reference Proteome: Yes;
DE  Interaction: P14907; IntAct: EBI-805203; Score: 0.59
DE  Interaction: P20449; IntAct: EBI-7266119; Score: 0.66
DE  Interaction: P36161; IntAct: EBI-7439043; Score: 0.40
DE  Interaction: P40064; IntAct: EBI-6332396; Score: 0.00
DE  Interaction: P40066; IntAct: EBI-797307; Score: 0.44
DE  Interaction: P40368; IntAct: EBI-790236; Score: 0.81
DE  Interaction: P38305; IntAct: EBI-761900; Score: 0.40
DE  Interaction: Q12315; IntAct: EBI-849734; Score: 0.32
DE  Interaction: P11484; IntAct: EBI-805203; Score: 0.53
DE  Interaction: P10592; IntAct: EBI-805203; Score: 0.35
DE  Interaction: Q12046; IntAct: EBI-854174; Score: 0.00
DE  Interaction: P16521; IntAct: EBI-7151928; Score: 0.40
DE  Interaction: Q04175; IntAct: EBI-1173457; Score: 0.40
DE  Interaction: Q06142; IntAct: EBI-1173489; Score: 0.61
DE  Interaction: Q02630; IntAct: EBI-6332418; Score: 0.00
DE  Interaction: P24870; IntAct: EBI-2611503; Score: 0.35
DE  Interaction: P29295; IntAct: EBI-2612057; Score: 0.35
DE  Interaction: P23291; IntAct: EBI-2614250; Score: 0.35
DE  Interaction: P24869; IntAct: EBI-2617071; Score: 0.35
DE  Interaction: P22696; IntAct: EBI-2883245; Score: 0.00
DE  Interaction: P39076; IntAct: EBI-3741411; Score: 0.35
DE  Interaction: Q12329; IntAct: EBI-3750967; Score: 0.35
DE  Interaction: P47138; IntAct: EBI-3760963; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-3772650; Score: 0.35
DE  Interaction: P39987; IntAct: EBI-3788010; Score: 0.35
DE  Interaction: P38788; IntAct: EBI-3790791; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-3799845; Score: 0.35
DE  Interaction: P32589; IntAct: EBI-3806436; Score: 0.35
DE  Interaction: P02829; IntAct: EBI-3812943; Score: 0.35
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044613;
GO  GO:0044614;
GO  GO:0005634;
GO  GO:0000774;
GO  GO:0060090;
GO  GO:0017056;
GO  GO:0003714;
GO  GO:0097064;
GO  GO:0006607;
GO  GO:0051664;
GO  GO:0006913;
GO  GO:0016973;
GO  GO:0006611;
GO  GO:0000055;
GO  GO:0000056;
GO  GO:0061912;
TP  Membrane Topology: Peripheral; Source: UniProt - Sequence Analysis;
SQ  MSSLKDEVPTETSEDFGFKFLGQKQILPSFNEKLPFASLQNLDISNSKSLFVAASGSKAVVGELQLLRDHITSDSTPLTF
SQ  KWEKEIPDVIFVCFHGDQVLVSTRNALYSLDLEELSEFRTVTSFEKPVFQLKNVNNTLVILNSVNDLSALDLRTKSTKQL
SQ  AQNVTSFDVTNSQLAVLLKDRSFQSFAWRNGEMEKQFEFSLPSELEELPVEEYSPLSVTILSPQDFLAVFGNVISETDDE
SQ  VSYDQKMYIIKHIDGSASFQETFDITPPFGQIVRFPYMYKVTLSGLIEPDANVNVLASSCSSEVSIWDSKQVIEPSQDSE
SQ  RAVLPISEETDKDTNPIGVAVDVVTSGTILEPCSGVDTIERLPLVYILNNEGSLQIVGLFHVAAIKSGHYSINLESLEHE
SQ  KSLSPTSEKIPIAGQEQEEKKKNNESSKALSENPFTSANTSGFTFLKTQPAAANSLQSQSSSTFGAPSFGSSAFKIDLPS
SQ  VSSTSTGVASSEQDATDPASAKPVFGKPAFGAIAKEPSTSEYAFGKPSFGAPSFGSGKSSVESPASGSAFGKPSFGTPSF
SQ  GSGNSSVEPPASGSAFGKPSFGTPSFGSGNSSAEPPASGSAFGKPSFGTSAFGTASSNETNSGSIFGKAAFGSSSFAPAN
SQ  NELFGSNFTISKPTVDSPKEVDSTSPFPSSGDQSEDESKSDVDSSSTPFGTKPNTSTKPKTNAFDFGSSSFGSGFSKALE
SQ  SVGSDTTFKFGTQASPFSSQLGNKSPFSSFTKDDTENGSLSKGSTSEINDDNEEHESNGPNVSGNDLTDSTVEQTSSTRL
SQ  PETPSDEDGEVVEEEAQKSPIGKLTETIKKSANIDMAGLKNPVFGNHVKAKSESPFSAFATNITKPSSTTPAFSFGNSTM
SQ  NKSNTSTVSPMEEADTKETSEKGPITLKSVENPFLPAKEERTGESSKKDHNDDPKDGYVSGSEISVRTSESAFDTTANEE
SQ  IPKSQDVNNHEKSETDPKYSQHAVVDHDNKSKEMNETSKNNERSGQPNHGVQGDGIALKKDNEKENFDSNMAIKQFEDHQ
SQ  SSEEDASEKDSRQSSEVKESDDNMSLNSDRDESISESYDKLEDINTDELPHGGEAFKAREVSASADFDVQTSLEDNYAES
SQ  GIQTDLSESSKENEVQTDAIPVKHNSTQTVKKEAVDNGLQTEPVETCNFSVQTFEGDENYLAEQCKPKQLKEYYTSAKVS
SQ  NIPFVSQNSTLRLIESTFQTVEAEFTVLMENIRNMDTFFTDQSSIPLVKRTVRSINNLYTWRIPEAEILLNIQNNIKCEQ
SQ  MQITNANIQDLKEKVTDYVRKDIAQITEDVANAKEEYLFLMHFDDASSGYVKDLSTHQFRMQKTLRQKLFDVSAKINHTE
SQ  ELLNILKLFTVKNKRLDDNPLVAKLAKESLARDGLLKEIKLLREQVSRLQLEEKGKKASSFDASSSITKDMKGFKVVEVG
SQ  LAMNTKKQIGDFFKNLNMAK
//