ID  P40548;
PN  HSP70 co-chaperone SNL1;
GN  SNL1;
OS  559292;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9450961}; Single-pass type II membrane protein {ECO:0000269|PubMed:9450961}. Nucleus membrane {ECO:0000269|PubMed:9450961}; Single-pass type II membrane protein {ECO:0000269|PubMed:9450961}.
DR  UNIPROT: P40548;
DR  UNIPROT: D6VVR3;
DR  Pfam: PF02179;
DR  PROSITE: PS51035;
DE  Function: Stimulator of ATPase activity of molecular chaperones of the HSP70 family (principally of the SSA class). Stimulation is important for HSP70-substrate complex dissociation after folding of newly synthesized or refolded proteins. SNL1 is probably involved in nuclear pore biogenesis and in particular the folding or refolding of misfolded NUP116, GLE2 and NIC96. {ECO:0000269|PubMed:12105220, ECO:0000269|PubMed:9450961}.
DE  Reference Proteome: Yes;
DE  Interaction: P39547; IntAct: EBI-7744731; Score: 0.37
DE  Interaction: P43542; IntAct: EBI-7744291; Score: 0.37
DE  Interaction: P04817; IntAct: EBI-7744327; Score: 0.37
DE  Interaction: P33767; IntAct: EBI-7744363; Score: 0.37
DE  Interaction: P49018; IntAct: EBI-7744397; Score: 0.37
DE  Interaction: P38992; IntAct: EBI-7744433; Score: 0.37
DE  Interaction: P25376; IntAct: EBI-7744479; Score: 0.37
DE  Interaction: P38356; IntAct: EBI-7744544; Score: 0.37
DE  Interaction: P38353; IntAct: EBI-7744633; Score: 0.37
DE  Interaction: P38298; IntAct: EBI-7744699; Score: 0.37
DE  Interaction: P35206; IntAct: EBI-7744715; Score: 0.37
DE  Interaction: Q06247; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P02557; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P09733; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P02994; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P00359; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P40150; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P11484; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P10591; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P11075; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P05754; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P02365; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P05753; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P0CX31; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P23248; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P14127; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P06367; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P05756; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P05317; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P29453; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P05739; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P49626; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P39741; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P14120; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P05736; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P38706; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P0C2I0; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P38754; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P40212; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P50108; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P38631; IntAct: EBI-803442; Score: 0.35
DE  Interaction: P50105; IntAct: EBI-7775425; Score: 0.40
DE  Interaction: Q02336; IntAct: EBI-8228340; Score: 0.22
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0005739;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0051087;
GO  GO:0043022;
GO  GO:0006999;
GO  GO:0006457;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MSHNAMEHWKSKLSKTSTSTYVLLAVIAVVFLVTIRRPNGSKGKSSKKRASKKNKKGKNQFEKAPVPLTLEEQIDNVSLR
SQ  YGNELEGRSKDLINRFDVEDEKDIYERNYCNEMLLKLLIELDSIDLINVDESLRRPLKEKRKGVIKEIQAMLKSLDSLK
//