ID  P43140;
PN  Alpha-1A adrenergic receptor;
GN  Adra1a;
OS  10116;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P35348}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P35348}. Membrane, caveola {ECO:0000250|UniProtKB:P35348}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK- mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.
DR  UNIPROT: P43140;
DR  Pfam: PF00001;
DR  PROSITE: PS00237;
DR  PROSITE: PS50262;
DE  Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: O08565; IntAct: EBI-21284814; Score: 0.27
GO  GO:0005901;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0098691;
GO  GO:0098982;
GO  GO:0098978;
GO  GO:0005887;
GO  GO:0099055;
GO  GO:0099056;
GO  GO:0016020;
GO  GO:0031965;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0005886;
GO  GO:0030315;
GO  GO:0030018;
GO  GO:0004937;
GO  GO:0004930;
GO  GO:0046982;
GO  GO:0007202;
GO  GO:0071880;
GO  GO:0071875;
GO  GO:0007512;
GO  GO:0007568;
GO  GO:0060402;
GO  GO:0061049;
GO  GO:0007267;
GO  GO:0000165;
GO  GO:0060073;
GO  GO:0010259;
GO  GO:0010507;
GO  GO:0001985;
GO  GO:0035024;
GO  GO:0150099;
GO  GO:0001994;
GO  GO:0035265;
GO  GO:0007200;
GO  GO:0097195;
GO  GO:0045760;
GO  GO:0060452;
GO  GO:0010613;
GO  GO:0007204;
GO  GO:0070374;
GO  GO:0010460;
GO  GO:0001996;
GO  GO:0043410;
GO  GO:1903997;
GO  GO:0090037;
GO  GO:0045987;
GO  GO:0032230;
GO  GO:0003084;
GO  GO:0001997;
GO  GO:0045907;
GO  GO:0008217;
GO  GO:2000300;
GO  GO:0009725;
GO  GO:0009410;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250};
SQ  MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVL
SQ  PFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIG
SQ  PLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
SQ  VPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSC
SQ  INPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFF
SQ  SSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
//